HIV infection is one of the most pressing medical and social problems in the whole world.
This article discusses one of the varieties of the complication of HIV infection such as HIV
associated encephalopathy. Clinical features and diagnostic criteria for the disease are
considered. Patients were examined using the Montreal cognitive function assessment
scale and symptomatic treatment with the nootropic drug choline alfoscerat

The aim of the work was to study the state of the prostacyclin-thromboxane system (PTS)
and platelet functions in patients with coronary heart disease (CHD). 86 patients with CHD
were examined. The state of PTS was examined by the content of prostacyclin and
thromboxane in the blood, determined by radioimmunological method. Platelet hemostasis
was studied by the aggregation properties of platelets and the platelet release reaction for
β-thromboglobulin determined by radio immunological method. In patients with IHD,
pronounced violations of the prostacyclin-thromboxane balance in the direction of the
predominance of thromboxane and an increase in the functional activity of platelets,
expressed in increased aggregation and platelet release reaction. In patients with IHD
with post infarction cardio sclerosis, the level of prostacyclin in the blood significantly
exceeds the level in patients without myocardial infarction. The content of prostacyclin and
thromboxane in the blood does not differ in patients with stable angina of functional
classes III and IY.

The immuno-oriented effects of polyoxidonium and immunoglobulin in the complex
treatment of patients with acute pancreatitis were studied. Patients with acute pancreatitis
from the first days of the disease revealed violations of the immune status in the form of
the development of immunodeficiency. Complex therapy, including immunomodulin or
polyoxidonium, allowed approximation of the level of cytokines to those of healthy donors.
Studies allow us to recommend the inclusion of polyoxidonium and immunomodulin in the
basic, comprehensive conservative therapy of patients with acute pancreatitis for the
purpose of immunocorrective therapy.

The article considers a clinical case of a young patient with autoimmune polyglandular
syndrome type 2, represented by type 1 diabetes mellitus, thyroid dysfunction and
primary adrenal cortex insufficiency.

Regardless of forceful medicines including careful resection, radiation treatment, and
cytotoxic chemotherapy, cerebrum malignant growth stays hopeless with a middle endurance
under 15 months and a 2-year endurance of 26.5 per cent1,2. The disappointment of
traditional oncology to annihilate glioblastoma, the most widely recognized dangerous
essential mind tumor, has provoked examiners to search for new and more focused on
helpful alternatives just as for improved prognostic biomarkers3. It is perceived that
cerebrum malignancy rises up out of numerous adjustments that initiate changes in
articulation examples of qualities and proteins that work in complex systems controlling basic
cell functions4. An essential assignment of the tumor research is the interpretation of subatomic biomarkers into clinical practice. Nonetheless, there is still not concurrence with
respect to the grouping and nature of steps that should be taken to warrant productive
interpretation of prognostic or potentially prescient biomarkers into clinical use and to the
presentation of novel restorative methodologies.

The urgency of the problem of developing and improving the methods of surgical
treatment of secondary deformities of the upper and lower jaws is determined by the
increase in the number of patients with facial skeleton deformities after primary
operations on the lip and palate. Numerous studies conducted by domestic and foreign
scientists indicate that only the study of the long-term results of treatment of patients
with jaw deformities can answer many questions, namely: how effective are the improved
or developed treatment methods, is a comprehensive approach to patient planning and
treatment appropriate with jaw deformities, what should be the sequence and terms of
rehabilitation treatment. Answers to these questions can be obtained by analyzing the
clinical material at long-term follow-up. An analysis of foreign and domestic works showed
that their authors perform orthognathic operations in patients

Nominal capital has been perceived as one significant nominal determinant for wellbeing,
however we despite everything have constrained information about how it tends to be
utilized to clarify imbalance in wellbeing. This examination researched the connections
between singular nominal capital and self-evaluated wellbeing by sexual orientation and
instructive level, and investigated if access to nominal capital may clarify the watched
inconsistencies in self-appraised wellbeing among people and distinctive instructive
gatherings. Study structure: Strategies:

The acute toxicity, cumulative effect and chronic toxicity of the drug "Ferulen" were
studied. During the experiments on white mice and rats with oral injection, it was found
that the drug ferulen by the parameters of acute toxicity belongs to the category of
practically non-toxic substances (V-class). The coefficient of sexual and species sensitivity
of the drug is not expressed.
Ferulen is not accumulated in the body of animals when used repeatedly. Long-term use
of ferulen for 90 days is well experienced by experimental animals. At the same time,
biochemical parameters indicated that there was a deduction in urea, cholesterol, βlipoproteins and lipids, as well as decrease in testosterone and luteinizing hormone in the
blood serum. In pathomorphological and histological studies a significant decrease in the
mass of androgen-dependent organs and destructive changes were found.

In world congenital anomalies are serious medical and social problem. They doubled over
decade 20th century and played significant role in the structure pathology and mortality in
the infant, perinatal and children. Now time is 1800 out of 10,000 children born with
congenital anomalies. Through progress made in our country in the future reform health
system strengthening and the protection of the health children, congenital abnormalities
play leading role in the structure morbidity disability and mortality. Reasons development
of 40-60% anomalies is unknown.

In recent years, doctors of ultrasonic diagnostics and cancers began to pay attention to
the possibility to obtain information about the status of the cervix, especially with the aim
of assessing the prevalence of tumor process, which is especially important in planning
treatment. However, the information to date is fragmented and based on a small number
of publications. However, to date not clearly developed sonographic criteria for cervical
cancer, given the clinical course of the disease and possibilities of modern digital (digital)
ultrasonic equipment, transvaginally, color echocardiography to better identify cervical
pathology, which will improve timely, differential, and clarifying the diagnosis of cervical
cancer.

The article is devoted to the study of the actual consumption of milk and dairy products
used by the population of the Fergana Valley. The object of the study was the food rations
of the population and milk consumed by the population, produced by dairy enterprises and
private farms in Fergana, Namangan and Andijan regions. The study was carried out using
an active questionnaire method. The results of the study showed that the actual
consumption of milk and dairy products by the population of the Fergana Valley is 2.5
times lower than the hygienic standards; it was revealed that in the structure of dairy
products, kefir is 34%, milk 23%, sour cream 9%, ayran and suzma 7%, other dairy
products are below 4%.

The problem of timely detection of breast cancer is not only in its asymptomatic
development, but also in the absence of reliable diagnostic markers that contribute to the
early detection of the neoplastic process. The main objectives of oncogenomics are to
study the molecular mechanisms of carcinogenesis and develop optimal methods for
preventing, diagnosing and monitoring cancer. One approach to solving this problem is to
analyze the epigenetic characteristics of the tumor genome.

An experimental study of the improved methods of colonic anastomoses on 30 mongrel
dogs was carried out. The study showed that the use of the methods of colonic
anastomoses developed by us does not lead to postoperative complications (anastomotic
leakage, narrowing of the anastomotic area, etc.), is easily feasible, does not require
expensive equipment, and can be performed in any surgical department.

This article gives information on Step-by-step rehabilitation of children with congenital
clearance of the upper lip and palate. A review of the reported data on the frequency of
birth, prevalence, territorial peculiarities, clinical manifestations, organization of medical
aid to children with congenital cleft lip and palate, staged rehabilitation is presented in the
paper.

While inspecting our medical clinic mortality record, we discovered higher careful mortality in
the long periods of summer season which enlivened us to investigate the effect of blistering
atmosphere in old careful sufferer. Meteorological elements, quiet attributes, careful hazard
factors and other related information were noted. Information was dissected utilizing
student's't' and z-test for factual noteworthiness. Results: There were factually critical
entanglements and delayed emergency clinic remain in bunch II when contrasted with I
(13.21±6.44 Versus 9.81±3.54 days, P esteem =0.01) on univariate examination. High
hazard sufferer had more complexities in blistering climate. Stepwise multivariate relapse
investigation indicated higher unfavorable effect of poor physical and cardiovascular status
than hot atmosphere.

Presence of Сirculating tumor cells (CTCs) in blood of disease patients, affirms about a
scattering of malignant growth cells to the fringe circulatory system, on the most punctual
phases of malignancy improvement and all the time vouches for an unfavorable clinical ebb
and flow, particularly it is associated with arrangement of metastases. Moreover, these
phones can speak to the base lingering infection and quantitative observing of CTCs level in
time of hostile to malignant growth treatment furnishes specialiCDC with important data. For
now the job of epithelial-to-mesenchymal travel (EMT) and mesenchymal-to-epithelial travel
(MET) in arrangement of different subpopulations CTCs, in development of malignancy
forceful properties. In this article we need to demonstrate the reason and issues of our
logical exploration - the cytological atomic investigation of flowing tumor cells have
separated by the size ward ISET innovation.

This article provides information on coronavirus infection, its origin and spread, which has
reached the level of a pandemic in the world. The etiology, resistance to the external
environment, epidemiology, pathogenesis, clinic, diagnosis, treatment regimen of COVID19, which shakes the whole world, are described. The World Health Organization has
provided 14 important rules for protecting against coronavirus infection, as well as
recommendations for people at risk to protect themselves and not infect others.

The effect of 1 - (- 4-dimethylaminophenyl) -6,7-dimethoxy-1,2,3,4-
tetrahydroisoquinoloin hydrochloride (conditionally –F-24) on antiarrhythmicactivity in
simulating calcium chloride arrhythmia, as well as acute toxicity in experiments, was
studied on white out bred rats with the intravenous route of administration. It was found
that the drug F-24 has a pronounced ant arrhythmic effect. The average effective (ED50)
ant arrhythmic dose is 4.8 mg/kg, the ant arrhythmic index is 20.3, which is significantly
more than the comparison drugs verapamil and lidocaine.

This work is devoted to the study of the effect of direct current on biological tissues, cells
and on the weight of the human body.The dielectric constant of certain substances and
the resistivity of organs is given. The course of physical and chemical changes under the
influence of direct current in cells, tissues and the entire body is indicated.