It is known that one of the diseases that are difficult to treat in modern medicine is an increase in blood pressure, i.e. hypertension. Hypertension is a pathology of the cardiovascular system, a complex disease characterized by an increase in arterial pressure, followed by organomorphological changes. Hypertension is mainly caused by constant nervousness, depression and stress, increased amount of adrenaline in the blood, alcohol consumption, excessive obesity and other factors. This disease is one of the main diseases that lead to complications such as myocardial infarction, stroke, heart attacks, and heart and kidney failure. The main symptoms of high blood pressure are headache, dizziness, ringing in the ears and heart failure. High blood pressure is more common in middle-aged and elderly people.

Homocysteine is a sulfur-containing amino acid that can act as an important biomarker of inflammatory processes, including cytokine storm, observed in various pathological conditions such as cancer and COVID-19. In the conditions of the cytokine storm characteristic of severe forms of COVID-19 and progressive stages of cancer, elevated homocysteine levels can increase oxidative stress and inflammatory reactions, which, in turn, exacerbates tissue and organ damage. Studies show that homocysteine can play a significant role in the pathogenesis of these conditions, affecting the vascular and immune systems. Thus, monitoring of homocysteine levels is important for the diagnosis, prognosis and development of new therapeutic strategies in the field of immuno-oncology and treatment of COVID-19.

ZENODO DOI:- https://doi.org/10.5281/zenodo.14162335

Atrioventricular (AV) heart block is a rare but significant adverse effect associated with the use of carbamazepine, a commonly prescribed antiepileptic medication. This abstract provides an overview of the mechanisms underlying carbamazepine-induced AV heart block, as well as management strategies for affected patients. The proposed mechanisms include direct effects on cardiac conduction pathways, alterations in electrolyte balance, and possible drug-drug interactions that may exacerbate cardiac conduction abnormalities. Clinically, patients may present with symptoms ranging from mild dizziness to severe syncope, necessitating timely diagnosis and intervention. Management strategies include discontinuation of carbamazepine, close monitoring of cardiac function, and potential use of temporary pacing in cases of significant AV block. This review aims to enhance awareness of this serious complication among healthcare professionals and underscores the importance of careful monitoring of cardiac function in patients receiving carbamazepine therapy. By understanding the mechanisms and appropriate management strategies, clinicians can improve patient outcomes and reduce the risk of life-threatening arrhythmias.