Articles
| Open Access |
DOI: Pre-Clinical Study Of Safeness Of The Drug Ferulen
Tukhtasheva Visola Farmonovna, , Phd Student, Junior Researcher, Department Of Pharmacology And Toxicology, S.Yu. Yunusov Institute Of The Chemistry Of Plant Substances, Academy Of Sciences Of The Republic Of Uzbekistan. Rejepov Jumadulla , Candidate Of Medical Sciences, Leading Researcher, Head Of The Department Of Pharmacology And Toxicology, S.Yu. Yunusov Institute Of The Chemistry Of Plant Substances, Academy Of Sciences Of The Republic Of Uzbekistan. Djakhangirov Farkhod Nabievich, , Doctor Of Medical Sciences, Chief Researcher, Department Of Pharmacology And Toxicology, S.Yu. Yunusov Institute Of The Chemistry Of Plant Substances, Academy Of Sciences Of The Republic Of Uzbekistan Azamatov Azizbek Azamat Ugli, , Junior Researcher, Department Of Pharmacology And Toxicology, S.Yu. Yunusov Institute Of The Chemistry Of Plant Substances, Academy Of Sciences Of The Republic Of Uzbekistan. Zakhidova Lola Tishaevna , Candidate Of Biological Sciences, Senior Researcher, Department Of Pharmacology And Toxicology, S.Yu. Yunusov Institute Of The Chemistry Of Plant Substances, Academy Of Sciences Of The Republic Of UzbekistanAbstract
The acute toxicity, cumulative effect and chronic toxicity of the drug "Ferulen" were
studied. During the experiments on white mice and rats with oral injection, it was found
that the drug ferulen by the parameters of acute toxicity belongs to the category of
practically non-toxic substances (V-class). The coefficient of sexual and species sensitivity
of the drug is not expressed.
Ferulen is not accumulated in the body of animals when used repeatedly. Long-term use
of ferulen for 90 days is well experienced by experimental animals. At the same time,
biochemical parameters indicated that there was a deduction in urea, cholesterol, βlipoproteins and lipids, as well as decrease in testosterone and luteinizing hormone in the
blood serum. In pathomorphological and histological studies a significant decrease in the
mass of androgen-dependent organs and destructive changes were found.
Keywords
ferulen, prostate
References
R. M. Khalilov, A. U. Mamatkhanov, L. D. Kotenko, Technology of obtaining the
estrogenic drug Ferule from the roots of a thin-cut ferule (Chemical – pharmaceutical
journal. Moscow 2009. volume 43, № 10. pp. 40-43.
Kotenko L. D., Khalilov R. M., Mamatkhanov A. U. Methods of qualitative and
quantitative analysis of the sum of esters from the roots of Ferula tenuisecta. Chemistry of
plant raw materials. Barnaul, 2009, № 1. pp. 89-92.
Khalilov R. M. "Development of technology for the production of substances based
on flavanoids and terpenoids from plant species of the Fabaceae and Apiaceae families".
Author’s abstract of the dissertation of the Doctor of Science (DSc). Tashkent, 2018.
Saidkhodzhaev A. I., Nikonov G. N., "Structure of Ferule", Chemistry of natural
compounds, 1974, no. 1, pp. 166-170.
Sagitdinov G. V., Saidkhodzhaev A. I., Malikov V. M. "Structure of uniferon and
uniferidine" Chemistry of natural compounds, 1978, no. 6, pp. 804-810.
A. G. Kurmukov, H. S. Akhmedkhodzhayeva. Estrogenic healing drugs from plants
of the genus Ferula. Tashkent, Ibn Sino Publishing house, 1994.
A. U. Mamatkhanov, S. S. Nasrullaev, M. A. Mamatkhanova. Estrogenic activity of
the sum of terpenoids from Ferula tenuisecta-panoferol and its effect on the productivity
of laying hens (materials of Rep. Scientific and practical conferences. "Actual problems of
biology and its teaching”. -ASDCF Tashkent, 2009. - p. 436-437.
Article Statistics
Copyright License
Copyright (c) 2020 The American Journal of Medical Sciences and Pharmaceutical Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.