In this work, the morphofunctional state has been studied at various times after the simulation of experimental syphilis.  It is noted that discirculatory and dystrophic changes develop in the early stages of the study. The appearance of focal and massive necrosis of hepatocytes is accompanied by the development of an inflammatory process in the form of lymphoid infiltration around necrosis and hypertrophy of Kupffer cells.  Subsequently, lymphohistiocytic infiltration spreads along the portal tracts, in which plasma cells and eosinophils appear, which are characteristic of syphilitic inflammation.

In the article Non-drug care is aimed at ensuring adequate oral hygiene in order to prevent the development and progression of the carious process, it includes three main components: oral hygiene training, controlled dental cleaning and professional oral and dental hygiene.

To investigate the experience of an interprofessional correspondence instructive intercession among nursing and clinical understudies. 45 clinical understudies and 50 nursing understudies partook in two-extended interprofessional relational abilities training meetings with interprofessional gatherings of 6-8 understudies each. The meetings depended on the Techniques and Instruments to Upgrade Execution and Patient Security educational plan. Risky correspondence situations were introduced and afterward reenacted by the understudies with pretends that portrayed enhancements in interprofessional correspondence. A short time later, stories portraying their experience were gathered from a center gathering meeting. Utilizing the ordinary substance examination approach, key expressions and proclamations were coded into topics. The investigation discovered that understudies felt expanded ability and certainty when reacting to struggle subsequent to rehearsing correspondence in a protected climate. In view of the chance to come to know their associates, understudies perceived that patient wellbeing was a common objective. Six subjects were extricated from the accounts portraying their support for measure, patient wellbeing, coming to know partner, support for apparatuses, aware coordinated effort, and boundaries to correspondence gave a structure to compelling and aware coordinated effort. A critical hindrance distinguished by understudies was that these correspondence strategies were not reliably shown during their clinical encounters. An accentuation on interprofessional relational abilities and collaboration should start in the scholastic setting and be supported in both the formal and secret educational plans.

Chronic heart failure (CHF) is a syndrome of several chronic diseases of the cardiovascular system. Among them, arterial hypertension (AH) occupies an important place. High blood pressure (BP) is considered to be the most common cause of CHF. The progression of hypertension towards heart failure includes geometric changes in LV and DD.

The risk of stroke in diabetic patients is significantly higher than in non-diabetic patients. Appropriate studies on the prevalence and characteristics of the onset of elderly diabetes with stroke in many countries are still lacking. Effective prevention and control still face enormous challenges. Older diabetic patients with osteoporosis need sensible intervention and treatment based on an individualised comprehensive assessment.

This literature review describes an analysis of the epidemic process associated with COVID-19 and presents possible scenarios. The most common anamnestic findings, symptoms of infection, clinical presentation, and possible complications are described in sufficient detail. The features of the course of COVID-19 in risk groups and algorithms of administrative and medical actions, which should form the basis of medical care for patients with cardiovascular, oncological, rheumatological diseases, pregnant women, etc., are highlighted.

The point of the review was to expand comprehension of the significance of ceaseless gathering and individual coaching for clinical understudies' close to home and expert turn of events. A subjective methodology with individual understudy meets and guided substance examination was picked to research and decipher the significance of mentorship. Five topics arose: psychosocial support by the tutor, a relationship with a doctor underneath the expert surface, space for something different, attention to one's own turn of events and reflection and learning with peers. The mentorship made a space where one could discuss 'different things'. The relationship with the tutor was more close to home than relations to instructors or chiefs. During the gathering meetings the understudies could reflect and learn in cooperation with others. Intermittent reflection about oneself and one's abilities prompted attention to one's own turn of events. Joined gathering and individual tutoring makes space for reflection on the humanistic parts of the expert job. A tutoring relationship can be strong and individual without continuous gatherings and knowing each other well. Coherence in mentorship assists understudies with thinking about and perceive their own proficient turn of events.

The article presents the method of transnasal surgical treatment of patients with a fracture of the medial wall of the orbit using the Volkov elevator as a repositioning tool and an iodine tampon as a fixation material, which allows efficient fixation of the medial orbit wall fragments and its soft tissue components, allowing to reduce the trauma of surgical intervention, to restore the eyeball position, and to eliminate the cause of emphysema and dynamic correction of postoperative diplopia in one-time operation.

Environmental change, climate warming, increasing population density, high migration activity and other factors are provoking the emergence and spread of new infections around the world. The emergence in December 2019 of diseases caused by a new coronavirus ("coronavirus disease 2019") has already gone down in history as not a disease of minor importance, but a disease of great magnitude engulfing the entire humanity. It is known that the most common clinical manifestation of the new infection is pneumonia and, in a large proportion of patients, respiratory distress syndrome. In our article we present a brief analysis and literature review of the epidemiological and epidemiological picture, in addition, we note the etiopathogenesis and some of the nuances of the disease.

This article explores modern methods of treating epilepsy. The problem of epilepsy is one of the most urgent in modern neurology and psychiatry. According to the European Commission on Epilepsy, about 50 million people in the world suffer from epilepsy. Epilepsy has attracted the attention of various specialists for many centuries, due to the spread of this disease in the population, the complexity of the etiology and pathogenesis, the polymorphism of clinical manifestations, the severity of the course, potentially severe clinical and social consequences, insufficiently effective treatment. According to WHO, the lack of adequate information on the epidemiological characteristics of epilepsy in many countries causes significant deficiencies in the organization of medical care. Epilepsy is one of the most common and severe diseases of the nervous system. The risk of developing epilepsy varies greatly with age. The peak incidence of epilepsy occurs in childhood and adolescence. After the second decade of life, the risk of epilepsy is significantly reduced. However, in some cases, epileptic seizures persist in patients until old age, and can also occur for the first time in old and senile age.

There have been several outbreaks of antimicrobial resistant (AMR) strains of Salmonella enterica serovar Typhi that cause extensively drug resistant (XDR) typhoid fever in Pakistan. It has been observed that many clinicians use serological diagnostic tests such as Widal agglutination, and TyphiDOT that detects IgM and IgG antibodies against the outer membrane protein of S. Typhi. However, it has been confirmed by many scientists that these test may lead to misdiagnosis against XDR S. Typhi. Due to lack of implementation strategies health authorities are unable to hamper Widal or TyphiDOT tests which are still practiced in many rural and urban areas.

Success or failure of implants depends on the health of the person receiving the treatment, drugs which affect the chances of Osseo integration, and the health of the tissues in the mouth. The amount of stress that will be put on the implant and fixture during normal function is also evaluated. Planning the position and number of implants is key to the long-term health of the prosthetic since biomechanical forces created during chewing can be significant.

Diseases of the circulatory system are considered one of the most urgent problems of the health system in all countries of the world, and one of its leading diseases – arterial blood pressure, with its relatively severe complications, is distinguished from other diseases of the same system. In the following years, in many developed countries of the world, including Uzbekistan, the main share of causes of death is being persecuted for diseases of the circulatory system. In European countries, this figure is 48% (in men - 43%, in women – 55%), in Uzbekistan, this is in the 2009 year.It is noted that from diseases (ischemic heart disease) to 50,1%, from hypertension to 17,7%) – 20,8% [1,3].

The reason for this cross sectional review is to examine understudy impression of learning conditions at a significant Australian College. Different parts of climate are analyzed between courses, year levels, instructive foundations and sexual orientation. The positive discernment held by Flinders University wellbeing science understudies towards their schooling and learning conditions is ideally characteristic of comparative courses inside Australia and globally. While future investigations might assist with affirming this, the current discoveries offer an opportunity to investigate the fundamental reasons for this energy in more profundity just as think about likenesses and contrasts between the particular wellbeing science disciplines. Radiography and clinical imaging, word related treatment, drug store, nourishment and dietetics, physiotherapy and social work courses at Flinders University. Accommodation examining was utilized and scores were analyzed across gathering factors recognized by means of segment data.

The measurably critical factors chose for expectation of difficulties were age, sexual orientation, smoking, season of finding, hazard characterization in the wellbeing administration, utilization of prescriptions and wretchedness. In the proposition of the scale after the multivariate investigation and chances proportion, set itself esteems 0-100, and the seriousness of hazard was characterized self-assertively. There were proposed care the board activities as indicated by the correspondence between the quantity of focuses and the danger surveyed on the scale. Consequently, the danger factors were distinguished and a prescient scale with activities for the board of care dependent on Brazilian rules was proposed.

The pandemic of the new coronavirus COVID-19 has switched medicine around the world on the primary fight against this infection. Patients with chronic liver diseases require increased attention of doctors during an epidemic, since against the background of an exacerbation of their disease, not only the risk of contracting the COVID 19 viral infection increases, but also its more severe course. Patients with confirmed COVID-19 with severe liver damage - high biochemical activity. According to some reports, patients with a severe course of COVID-19 have an increase in ALT levels, a decrease in the number of platelets, a decrease in the level of albumin, and a connection (although not all indicators) with a higher risk of mortality is possible.

"One picture is worth a thousand words" - Frederic Bernard Currently, many dentists use a camera in their daily practice, turning into photographers for a while. In aesthetic dentistry, the main tool for diagnosis and communication is the art and practice of obtaining a photo. The use of dental photography is the standard of modern dental treatment, since photographs of the results of treatment facilitate understanding of the features of dental intervention. And most importantly, visualization increases the motivation of the patient and promotes the establishment of friendly relations between him and the doctor.

The use of intraosseous dental implants is one of the most distinctive features of modern dentistry. Implant-based prosthetic constructions are more physiological in comparison with traditional prosthetic techniques, since they transfer the chewing load directly to the alveolar bone of the jaw, besides, they do not require the preparation of neighboring teeth. Therefore, it is not surprising that in recent years, their use has become quite well known and appreciated by practitioners and patients alike. However, despite all the advantages, there are a number of contraindications and limiting factors to the use of implants [5,11].

The improvement of methods of treatment of odontogenic cysts of the jaw remains the actual problem of surgical stomatology. This is caused by the widespread of the disease, the possibility of such complications as cyst abscesses, osteomyelitis development, jaw deformities, tooth loss, pathological fracture occurrence and even the so-called central jaw cancer from the epithelium of cyst walls, and also rather frequent relapses after surgical treatment carried out.

A study of the general increase in the incidence of the disease is currently being carried out by the epidemiological service, according to which in 95% of cases people become infected while living together or in the same house with an infected person. Among those arriving from abroad, one or two infected persons are detected every day. In 99% of cases, the disease is found in those who have had contact with infected citizens living in Uzbekistan[1,3].

The study of the literature has shown that the morphological status of the thymus has been studied superficially in many works. The cellular composition of the thymus parts under the influence of physical or chemical environmental factors in the age aspect has not been studied enough. All this requires a more detailed study of the morphological changes occurring in this organ under the influence of various factors.

This research aimed to study the nature of pathomorphological changes in the kidney in chronic alcoholism in rats. In the present study, we have studied experimentally the nature of pathomorphological changes in the kidneys in chronic alcoholism in rats. The longer the intoxication is, the more the kidneys are damaged and homeostatic shifts are more pronounced in young animals. In an experiment on rats, it was found that taking ethanol orally has a short-term effect on kidney tissue and affects water-salt metabolism. Histologically, there are foci of acute inflammation of nephrocytes, spasm of small arterioles, and on the 15th day, atrophic changes in the renal parenchyma. Long-term alcohol intoxication (AIM) leads to persistent morphological disorders of the nephron, which are manifested in changes in the shape and size of the glomerulus, partial sclerosis of loops, vacuolar dystrophy of endothelial cells and partial vacuolar dystrophy of the tubular epithelium, especially the distal part.

In the article, according to the data of foreign scientists and the authors' own observations, modern methods of topical therapy for acne and post-acne are presented.

Tuberculous lymphadenopathy without HIV infection, in comparison with those with HIV infection, was characterized by a more favorable clinical course, limited lesion and, especially important, limited caseous-necrotic changes. Analysis of the histological picture of the removed lymph nodes in patients with HIV-i made it possible to distinguish three activities of tuberculous lymphadenopathy: an inactive phase (with a predominance of a productive cellular reaction) - in 3 patients (5.3%), an active (with a predominantly productive-necrotic tissue reaction) - in 11 patients (19.3%), the phase of progression of the pathological process (mainly necrotic lesions, suppuration and formation of fistulas) - in 43 patients (75.4%). It was found that the inactive phase is 5.5 times more common in patients without HIV than in patients with HIV (29.3% and 5.3%, respectively, P˂0.001), while the active phase and the progression phase was 1.5 and 1.3 times more frequent in patients with HIV than in patients without HIV (19.3% and 13.1, respectively, P˃0.5; 75.4% and 57, 6%, respectively, P˂0.02).