The article is devoted to general issues of classification and differential diagnosis of thrombocytopathy. Features of pathogenesis, clinical course and diagnosis of certain rare inherited thrombocytopathies are highlighted. Particular attention is paid to the formation of the molecular basis of these diseases. The basic genetic mutations associated with a number of thrombocytopathies are given.

The article describes the methodology of using the technology of role-playing games in practical classes at the university, which belongs to the advanced pedagogical methods. For, a problem situation, solving a problem, finding a suitable solution to a problem together teaches students to think wider, deeply analyze the situation, move away from analyzing the situation, paves the way for mental and emotional development.

This article is mainly about dental thieves and the full information about the diseases that arise from them. The article describes various treatments and recommendations for dental diseases.

Maxillo-facial area phlegmon is a common, serious, costly and deadly disease. Over the last decade, the attention of researches and clinical was focused on the search the optimal methods of diagnosis and treatment of this pathology. It is necessary for timely initiation of adequate causal antibiotic therapy and prevention of complications. Gas chro- matography – mass-spectrometry is one of the most powerful analytical methods to obtain data on the exciter. The review highlights the current understanding of the role and potential of the method in the improvement of measures aimed at prevention and treatment of phlegmons and their complications.

Neuroses are psychogenic disorders that develop as a result of long-term exposure to a traumatic event with low intensity and sharpness. In these cases, there is usually talked of disagreements in the family, production, and work community, which are not even perceived by the patient as a factor of emotional trauma. The depth of mental disorders is relatively low in neuroses - there are no deep disturbances of thinking, cognition and consciousness, and a critical attitude to others and one's own state is preserved. The article looks into the neurosis and its causes and correlation with other illnesses.

This article discusses the issues of early diagnosis of non-specific aortoarteritis are not generally accepted and therefore remain relevant. Takayasu syndrome (non-specific aortoarteritis) is an autoimmune inflammatory disease that affects the aorta and its branches, belongs to the group of systemic vasculitis, is characterized by the development of productive inflammation in the wall of large arteries leading to their obliteration, there is no pulsation due to frequent cases of loss of pulse in the upper extremities. The course of the disease is progressive with periodic exacerbations and deterioration of blood circulation in ischemic organs, as well as an unfavorable prognosis. Modern data on the etiology, pathogenesis, and clinical picture of Takayasu syndrome are presented. An important role in the diagnosis of non-specific aortoarteritis is played by computer and magnetic resonance imaging, as well as ultrasound examination of vessels that can detect typical signs of stenosis or aneurysm of the arteries. Treatment of the disease with the use of drugs aimed at suppressing the activity Of b cells of the immune system, as well as with the use of an IL-6 receptor inhibitor, is discussed. In order to attract the attention of General practitioners to a rare rheumatological problem – Takayasu aortoarteritis – the results of their own observations are presented. The clinical picture of the disease in a child is described.

Obesity negatively affects structure of renal tissue and increases the risk of developing renal failure and progression arterial hypertension. Adipose tissue is also a source of synthesis of all components renin-angiotensin system and can actively produce angiotensin.

This article has been reported mainly for the Prevention of caries and dental diseases in children. The article mentioned the causes of the origin of the common disease and the first AIDS. In addition, the article mentioned the stages of development of dental diseases.

Objective: to study the relationship between hematocrit indicators during the first 6 hours after the patient's hospitalization and the development of complications of acute pancreatitis.

Materials and methods. The study included 243 patients with acute pancreatitis. All patients were examined for hematocrit at admission. The multivariate analysis made it possible to determine whether there was a correlation between the presence of hemoconcentration in patients (hematocrit ≥43) at the time of admission with the development of complications of acute pancreatitis. The predictive effectiveness of this marker was estimated by the area under the ROC curve.

Results. Severe acute pancreatitis was observed in 36 (14.8%) patients. Average hematocrit values were 43.2 ± 6.4% (P0,01). In the first 6 hours after admission, hemoconcentration was observed in 72.2% of patients with acute pancreatitis who later developed complications of this disease.

Background: The relevance of the problem of arterial hypertension (AH) is determined by its high frequency in the population, the influence on the state of health, working capacity and longevity of the population. Persons of old and old age, as a rule, have a significant amount of risk factors for cardiovascular diseases, very often there are lesions of target organs and associated clinical conditions, therefore, the majority of painful AHs of these age-related categories belong to high and very high-risk groups.

The pyloric-duodenal stenosis (PDS) concerns frequent complications of stomach ulcer and takes the third place after such life-threatening complications duodenal ulcers as punching and ulcer gastrointestinal bleedings. Frequency of occurrence ulcer PDS makes, according to different researchers, 10-18 % and are diagnosed mainly for patients with is long proceeding duodenal an ulcer. Quite often there is simultaneous combination PDS to other complications of stomach ulcer of a duodenal gut that by all means complicates treatment tactics.

This article include prevention of anemia in patients with tuberculosis. tuberculosis induces a systemic inflammatory state affecting iron homeostasis. patients with tuberculosis often have additional comorbidities such as anemia which can result in poorer treat outcomes. we studied the contribution of anemia and the role of the iron regulatory hormone hepcidin among tuberculosis patients and household contacts.

Presentation: Reproductive wellbeing, kid wellbeing and nourishment are center needs for any
nation, all the more so for India, with the world's most noteworthy weight of maternal, infant, and
youngster passings.
Targets: To evaluate the interpretation wellbeing and youngster wellbeing depiction of the
characterized populace utilizing regenerative wellbeing and kid wellbeing markers in the greensward
execution zone of Rajeswari Medical College and Hospital.
Materials and strategies: A people group based cross-sectional investigation was led among ladies of
regenerative age gathering utilizing a pretested and semistructured survey which included
interpretation wellbeing and kid wellbeing markers.
Strategy for examination: Data product dissected utilizing Statistical Package for Social Sciences
programming.

The Dental Index was created to preserve and promote public health in accordance with the 8020 program methodology. One of the important population groups is student youth. The health of students is of great social and medical importance. Student youth is one of the main reserves of highly qualified specialists for various branches of national economy. Modern students will have to implement the most important social functions of society in the future: professional and labor, reproductive, intellectual and moral. An important factor in the preservation of health is lifestyle, the share of which is estimated at more than 50%. The way of life of students from hygienic positions has a number of defects that lead to deteriorating health.

Electro-neuromyographic examination allows you to accurately assess muscle activity and pathogenetic changes in nerve tissues. When compression and injuries of the musculo-nervous system application based on electro stimulation is widespread and quite reasonable and  is considered a highly effective method. The use of electrical stimulation in  in patients with hemophilia improves muscles and peripheral nerves  microcirculation and metabolism.

The article is scientifically based on the prevalence and causes of cutaneous leishmaniasis in the southern region of Uzbekistan, Surkhandarya region.

The results of blocked intramedullary osteosynthesis (BIOS) in 50 patients with fractures of the distal and diaphysis of the tibia are presented. Blocked intramedullary osteosynthesis is a reliable and predictable method for the treatment of diaphyseal fractures of the tibia, which allows the restoration of limb function in the shortest possible time in most patients.

Purpose of research. To assess the impact of the severity of motor disorders in children with cerebral palsy on nutritional status.

Materials and methods of research. The study included 102 children with cerebral palsy aged 2 to 17 years, 60 boys (58.8%) and 42 girls (41.2%). The average age of the children was 7.23 ± 4.9 years. Patients were ranked by age group in accordance with the age classification of the GMFCS scale. All children underwent a comprehensive clinical and neurological examination, nutritional status assessment, and anthropometry (measurement of shoulder circumference and plicometry). During anthropometry, the control group included 30 healthy children with an average age of 7.7±4.2 years.

Results. It was found that with an increase in the severity of motor disorders, the number of children with protein-energy deficiency increases from 50% at level I to 100% at level V on the GMFCS scale (the significance of differences in Pearson's Chi-square was confirmed statistically: 9.32, p = 0.002069). At the same time, a severe degree of protein-energy insufficiency was observed mainly in double hemiplegia (amounting to 40.9%). Prognostically, cerebral palsy was the most favorable type of spastic hemiparesis and spastic diplegia, with a predominance of protein-energy insufficiency of a mild degree, amounting to 45.8% and 60%, respectively. In 71.6% of cases (n=73), children with cerebral palsy were diagnosed with oral-motor dysfunction of varying severity, problems with food consumption and, as a result, a noticeable lag in anabolic processes. Statistically significant differences were found in the frequency of feeding difficulties in children with levels I and V of motor abilities (Pearson's Chi-square: 20.12,           p = 0.000005).

This article is mainly included in the information in the article about dental diseases and how to be without them. The article mainly contains information on dental diseases.

The study involved 2850 children with dysmetabolic nephropathies at the age from 1 month to 3 years. The study showed that dysmetabolic nephropathy is a genetically determined pathology with early manifestation, which is often found in the practice of a pediatrician and requires medical examination on a family basis.

The purpose of this study was to investigate the function of knee joints in patients with early osteoarthritis (OA, according to the criteria of the American rheumatology Association 2010) stage I-III using visual analogue scale (VAS) for pain intensity and treatment outcomes, Lequesne index, expert indicators, samples of 4 meter walk to assess the effectiveness of intra-articular injection Hyaluronic Chondro. 80 patients aged 28 to 55 years were examined. The treatment regimen included recommendations from the European rheumatology League (EULAR, 2016) and Russia (Nasonov E. L., 2017). The results of therapy were evaluated in two groups. The first group included 43 patients who received Hyaluronic Chondro in the form of intra-articular injections, the second-37 patients who received chondroprotectors inside or in the form of intramuscular injections. Conclusion. Intra-articular administration of the drug Chondrogard has a positive clinical effect in early stage II-III OA with moderate impairment of knee joint function. The course of treatment should last at least 2 months

For stable memorizing and remaining in mind a great volume of information that is necessary for further medical activity the mnemotechnique methods can be used on educational process in medical higher schools, that is combination of methods and means making the process of memorizing easier and increasing the memory volume by creating artificial associations.

Currently, despite significant achievements in the field of surgery, anesthesiology and resuscitation, the results of treatment of patients with advanced purulent peritonitis remain one of the most intractable problems, almost every sixth patient with acute surgical diseases and injuries of the abdominal cavity is admitted to medical institutions with peritonitis [1,3] Common peritonitis in 17-29% complicates the course of most acute surgical diseases and is the main cause of deaths in surgical hospitals [3,7]. Lethality in advanced peritonitis remains extremely high and reaches 20-39% [1,2,4,5]. In recent decades, great importance has been attached to recording intra-abdominal pressure in purulent pathology of the abdominal cavity. It was found that intra-abdominal hypertension occurs in every third patient with acute surgical pathology and negatively affects the functioning of all organs and systems of the body [1,6,8]. Pathological changes that occur with acute and excessive increase in intra-abdominal pressure (IAP) are manifestations of abdominal compartment syndrome (ACS) with disorders of the cardiovascular system; urinary disorders, disorders of perfusion of internal organs and the development of intestinal ischemia, which contributes to bacterial translocation and endogenous infection [2,7,8]. Ischemic blood flow disorders of the splanchnic zone are fraught with the development of bacterial translocation and the development of systemic inflammatory response syndrome and multiple organ failure (PON). Unsatisfactoriness with such results gave rise to a fundamentally different approach to the surgical treatment of common forms of peritonitis-the introduction of an open abdominal management method based on the ideas of I. Mikulich (1881), Jean-Louis Faure (1928), N. S. Makoch (1984) and D. Steinberg (1979).

Parturiency actuated hypertension (PIH) is one of the most notable purposes behind both maternal
and neonatal terribleness. A variety of hematological anomalies may occur in women with PIH of
which platelet is the most generally perceived. Objections: This assessment was done to measure the
recurrence of platelet in pregnant women resolved to have PIH and to relate the reality of PIH with
the degree of .Platelet count alone can't be relied on to study the earnestness of PIH. The mission for
a fundamental viable test for brief organization and expectation of maternal and neonatal
terribleness performable in a nation facility set up still continues

In view of the special medico-social importance of cardiovascular diseases, their prevention is one of the most important tasks facing medical science and the health care system. Ischemic heart disease and its most serious complication, acute myocardial infarction, is the main and most dangerous disease of the cardiovascular system. Epidemiological studies and screening measures for the prevention of cardiovascular diseases contain scientific data that can not only reduce the incidence, but, undoubtedly, prolong the life of the elderly and senile population.