Clinical Course Of Non-Specific Aortoartheritis (Disease Takayasu) (Casefrompractice)
Tuxtayeva Mashxura Muxiddinovna , Assistant Of The Department, 2-Pediatrics And Neonatology Course, Samarkand State Medical Institute, UzbekistanAbstract
This article discusses the issues of early diagnosis of non-specific aortoarteritis are not generally accepted and therefore remain relevant. Takayasu syndrome (non-specific aortoarteritis) is an autoimmune inflammatory disease that affects the aorta and its branches, belongs to the group of systemic vasculitis, is characterized by the development of productive inflammation in the wall of large arteries leading to their obliteration, there is no pulsation due to frequent cases of loss of pulse in the upper extremities. The course of the disease is progressive with periodic exacerbations and deterioration of blood circulation in ischemic organs, as well as an unfavorable prognosis. Modern data on the etiology, pathogenesis, and clinical picture of Takayasu syndrome are presented. An important role in the diagnosis of non-specific aortoarteritis is played by computer and magnetic resonance imaging, as well as ultrasound examination of vessels that can detect typical signs of stenosis or aneurysm of the arteries. Treatment of the disease with the use of drugs aimed at suppressing the activity Of b cells of the immune system, as well as with the use of an IL-6 receptor inhibitor, is discussed. In order to attract the attention of General practitioners to a rare rheumatological problem – Takayasu aortoarteritis – the results of their own observations are presented. The clinical picture of the disease in a child is described.
Keywords
Takayasu syndrome, etiology
References
Takayasu M. A case with peculiar changes of the central retinal vessels. ActaSocietatisophthalmologicaeJaponicae / M. Takayasu. – Tokyo, 1908. – P. 12: 554.
Martorell F. El sindrome de obliteraciоn de los troncossupraaоr-ticos. MedicinaClinica / F. Martorell, J. F. Tersol. – Barcelona, 1944. – P. 2: 26–30.
Pathogenesis of Takayasu’s arteritis: a 2011 update / L. Arnaud,J. Haroche, A. Mathian, G. Gorochov, Z. Amoura // Autoimmun Rev. – 2011. Vol. 11(1). – P. 61–67.
Takayasu arteritis. A study of 32 North American patients / S. Hall,
W. Barr, J.T. Lie, A.W. Stanson, F.J. Kazmier // Hunder. Medicine (Baltimore). – 1985. – Vol. 64(2). – P. 89–99.
Phillip R. Mortality in systemic vasculitis: a systematic review /
R. Phillip, R. Luqmani // ClinExpRheumatol. – 2008. – Vol. 26.
– Vol. 5. – Suppl 51. – S94-104.
Clinical characteristics and outcomes of Takayasu’s arteritis: analysis of 108 patients using standardized criteria for diagnosis, activity assessment, and angiographic classification / M.C. Park, S.W. Lee, Y.B. Park, N.S. Chung // Lee Scand J Rheumatol. – 2005. – Vol. 34(4). – P. 284–292.
Maksimowicz-McKinnon K. Limitations of therapy and a guarded prognosis in an American cohort of Takayasu arteritis patients /
K. Maksimowicz-McKinnon, T.M. Clark, G.S. Hoffman // Arthri-tis Rheum. – 2007. Vol. 56(3). – P. 1000–1009.
Quality of life of patients with Takayasu’s arteritis / [C.J. Abu-larrage, M.B. Slidell, A.N. Sidawy, et al.] // Vasc. Surg. – 2008.
– Vol. 47(1). P. 131–136.
Quality of life in patients with Takayasu’s arteritis is impaired and comparable with rheumatoid arthritis and ankylosing spondylitis patients / [S. Akar, G. Can, O. Binicier, K. Aksu, B. Akinci, D. Solmaz, et al.] // Clin.Rheumatol. –2008. – Vpl. 27(7). – P. 859–865.
Angiographic findings of Takayasu arteritis: new classification / [A. Hata, M. Noda, R. Moriwaki, F. Numano] // Int.J.Cardiol. – 1996. – Vol. 54. – S155-163.
Article Statistics
Copyright License
Copyright (c) 2020 The American Journal of Medical Sciences and Pharmaceutical Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.