Chronic venous hypertension (CVH) triggers a whole cascade of pathological reactions, the ultimate result of which is gross changes in the trophism of soft tissues of the lower extremities. The main hemodynamic factor leading to hypertension in the superficial venous system and, subsequently, to trophic changes in the lower limb, is blood reflux from deep veins, and it is associated with valve insufficiency at the mouth of the great and small saphenous veins (vertical reflux), as well as incompetency of perforators (horizontal reflux). Moreover, 90% of the latter are localized in the calf region, of which 87% belong to the veins of the Cockett I-III zone.

Colonic perforations are typically attributed to various medical and surgical causes, but rare instances arise from unconventional incidents. This case report presents an unusual occurrence of sigmoid colon perforation resulting from exposure to compressed air. A 45-year-old male, with no history of gastrointestinal disorders, presented with sudden onset abdominal pain and signs of peritonitis. Upon investigation, a history of accidental exposure to high-pressure compressed air while working was revealed. Subsequent imaging and exploratory laparotomy confirmed a perforation in the sigmoid colon. The patient underwent surgical repair and had an uneventful postoperative recovery. This report highlights the potential dangers associated with non-medical uses of compressed air and emphasizes the importance of a thorough patient history in diagnosing uncommon etiologies of gastrointestinal perforations.

Although time rapidly develops, it has not failed to show its influence on humanity. The abundance of information, noise, the development of the Internet, etc. affect the human psyche. Today, the demand for antidepressants is growing. Of course, the low side effects of the drug, long dosage interval, and naturalness lead to many advantages. The purpose of this research is to study the toxicity and general pharmacological properties of an extract prepared from the plant Cistanche Mongolica, growing wild in the Republic of Uzbekistan, as well as to determine the antidepressant properties of this extract.

Physical activity is defined as bodily movement, which allows any energy expenditure greater than resting levels. Regular practice generates gains in mental and physical health, so physically active people are more vigorous and willing to carry out their professional and daily activities, enhancing their interpersonal relationships. It is known that there is a low prevalence of healthy behaviors in relation to physical activity among health professionals. This is a literature review, added to a cross-sectional data collection through digital media with an anonymous form that does not require submission to the research ethics committee. The analysis of the data showed that 31.9% of the absolute population surveyed had some previous illness or was taking daily medication. Of these, 52.5% had psychiatric disorders, 20.7% respiratory diseases and 20.3% musculoskeletal diseases, which correlate directly with limiting factors for physical activity. The findings indicate that regular exercise is an ally in improving or maintaining various health indicators. For this reason, simple and inexpensive measures such as assessing the level of physical activity and monitoring these professionals reduces hospital absenteeism, increases personal performance and consequently improves the quality of the service provided to the population.

we studied patients with ischemic stroke with antihypertensive medication for high arterial hypertension.

Material and methods: we studied 28 patients in the general intensive care unit of multidisciplinary TMA with acute cerebral ischemia syndrome caused by ischemic-type ACCD. The age of the patients was on average 61±7 years. There were 20 males and 8 females. The level of consciousness was assessed using the Glasgow scale. It ranged from 4 to 10 points.

Results: the given data clearly indicate a more pronounced decrease of SBP, DBP, ICP during intravenous infusion of Tahiben at the stages of the study. A significant difference in the duration of drug effects in the studied groups was noted. Thus, when using Tahiben, the target level of SBP and DBP could be maintained up to 220±54 minutes, while in the standard treatment group it was maintained for 68±8 minutes.

Conclusions: intravenous administration of Tahiben (urapidil) at the early hospital stage in patients with arterial hypertension against the background of standard baseline therapy of ACCD is an effective and safe method of urgent therapy, providing dosage BP reduction by 15-25% of the initial one.

The results of surgical treatment of 71 patients with chronic venous insufficiency (CVI) of types C-4 (34), C-5 (17), C-6 (20) were analyzed. Of these, 34 patients of the main group underwent minimally invasive interventions. The sufficient effectiveness of crossectomy, supplemented by sclerotherapy, has been proven, allowing more than 80% of cases to avoid traumatic interventions.

This review article comprehensively analyzes contemporary methods in cleft rhinoplasty with secondary and residual deformities. The study encompasses the historical development of rhinoplasty, modern technologies, including trimming techniques and 3D printing, as well as challenges and prospects in this field. Clinical studies, ethical aspects, investigations of postoperative complications, and innovations in materials and biotechnology are considered in the context of optimizing outcomes in reconstructive rhinoplasty. The article's conclusion highlights key directions for future research, proposing a path toward improving practices and achieving optimal results in this medical specialty.

This research endeavors to expose the hidden dangers of schistosomiasis among school-aged children in Northern Nigeria by systematically investigating its prevalence and associated risk factors. Through a comprehensive analysis of epidemiological data, water sanitation conditions, and socio-economic factors, the study aims to unveil the intricate dynamics contributing to the spread of schistosomiasis. Insights derived from this research have the potential to inform targeted interventions, public health policies, and educational initiatives, contributing to the mitigation of this silent threat in Northern Nigeria.

Currently, in medicine the number of patients with burn injuries. This necessitates further improvement of local treatment methods for such patients. Although several types of wound dressings have been developed, no gold standard has yet been developed. Therefore, the development of easy-to-use, bactericidal effective and inexpensive wound coverings is relevant, taking into account the requirements for coatings.

Primary chronic headaches affect a substantial portion of the population, being predominant contributors to headache-related disability. Magnetic Resonance Angiography has emerged as a valuable diagnostic tool in examining the visibility of posterior communicating arteries in primary chronic headaches. Study at AKFA Medline University Hospital, involved 53 patients who were subjected to comprehensive neurological evaluations, assessed headache severity and frequency, and advanced imaging procedures. Six participants were excluded due to concomitant illnesses. According to 47 patients (M:F= 20:27) reported chronic headaches: n=41 (87.2%) showed no Posterior Communicating Artery visualization and n=6 (12.8%) showed Posterior Communicating Artery visualization. The mean age of participants was 42.3 ± 13.4. Alterations in the standard structure of the Circle of Willis might influence the frequency and intensity of headache symptoms. There has been a noted correlation between irregularities in the Circle of Willis with patients experiencing headaches, and a possible genetic involvement. More research is needed to understand the mechanisms.