Epidemiological characteristics of respiratory syncytial virus in children
Artikova Magina Akmalovna , Tashkent Pediatric Medical Institute, Tashkent, UzbekistanAbstract
Respiratory syncytial virus (RSV) is one of the most common respiratory diseases, causing more than 30 million cases of lower respiratory tract infections (LRTI) and 3 million hospitalizations worldwide each year [1]. RSV is especially dangerous for people with weakened immune systems, chronic lung or heart diseases, and for people under 5 years of age or over 65 years of age. RSV is the leading cause of lower respiratory tract infection (eg, bronchiolitis) in children under 1 year of age [5]. The incidence of RSV hospitalization is highest among infants younger than 6 months (2 percent per year, 95% CI 0.1–4), and significantly higher in premature infants younger than 1 year (6 percent per year, 95% CI 4–11). In an international multicenter case-control study, RSV was the most common pathogen isolated from children aged 1 to 59 months hospitalized with severe pneumonia in Africa and Asia, accounting for 31 percent of cases [24].
Keywords
References
Shi T, McAllister DA, O'Brien KL, et al. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study. Lancet. 2017;390(10098):946‐958. doi: 10.1016/S0140-6736(17)30938-8 [DOI] [PMC free article] [PubMed] [Google Scholar]
National Foundation of Infectious Diseases . Respiratory syncytial virus in older adults: a hidden annual epidemic. September 2016. Accessed May 5, 2021. https://www.nfid.org/wp-content/uploads/2019/08/rsv-report.pdf
Shi T, Ooi Y, Zaw EM, et al. Association between respiratory syncytial virus‐associated acute lower respiratory infection in early life and recurrent wheeze and asthma in later childhood. J Infect Dis. 2020;222(Suppl 7):S628‐S633. doi: 10.1093/infdis/jiz311 [DOI] [PubMed] [Google Scholar]
Young M, Smitherman L. Socioeconomic impact of RSV hospitalization. Infect Dis Ther. 2021;10(Suppl 1):35‐45. doi: 10.1007/s40121-020-00390-7 [DOI] [PMC free article] [PubMed] [Google Scholar]
Hall CB, Weinberg GA, Iwane MK, et al. The burden of respiratory syncytial virus infection in young children. N Engl J Med 2009; 360:588.
Rose EB, Wheatley A, Langley G, et al. Respiratory Syncytial Virus Seasonality - United States, 2014-2017. MMWR Morb Mortal Wkly Rep 2018; 67:71.
Obando-Pacheco P, Justicia-Grande AJ, Rivero-Calle I, et al. Respiratory Syncytial Virus Seasonality: A Global Overview. J Infect Dis 2018; 217:1356.
Spence L, Barratt N. Respiratory syncytial virus associated with acute respiratory infections in Trinidadian patients. Am J Epidemiol 1968; 88:257.
Sung RY, Murray HG, Chan RC, et al. Seasonal patterns of respiratory syncytial virus infection in Hong Kong: a preliminary report. J Infect Dis 1987; 156:527.
Cane PA. Molecular epidemiology of respiratory syncytial virus. Rev Med Virol 2001; 11:103.
Centers for Disease Control and Prevention. Health Alert Network. Increased interseasonal respiratory syncytial virus (RSV) activity in parts of the southern United States. https://emergency.cdc.gov/han/2021/han00443.asp (Accessed on June 30, 2021).
Ugh R, Avner JR. Delayed Seasonal RSV Surge Observed During the COVID-19 Pandemic. Pediatrics 2021; 148.
Van Brusselen D, De Troeyer K, Ter Haar E, et al. Bronchiolitis in COVID-19 times: a nearly absent disease? Eur J Pediatr 2021; 180:1969.
Yeoh DK, Foley DA, Minney-Smith CA, et al. Impact of Coronavirus Disease 2019 Public Health Measures on Detections of Influenza and Respiratory Syncytial Virus in Children During the 2020 Australian Winter. Clin Infect Dis 2021; 72:2199.
Friedrich F, Ongaratto R, Scotta MC, et al. Early Impact of Social Distancing in Response to Coronavirus Disease 2019 on Hospitalizations for Acute Bronchiolitis in Infants in Brazil. Clin Infect Dis 2021; 72:2071.
Nolen LD, Seeman S, Bruden D, et al. Impact of Social Distancing and Travel Restrictions on Non-Coronavirus Disease 2019 (Non-COVID-19) Respiratory Hospital Admissions in Young Children in Rural Alaska. Clin Infect Dis 2021; 72:2196.
Haddadin Z, Schuster JE, Spieker AJ, et al. Acute Respiratory Illnesses in Children in the SARS-CoV-2 Pandemic: Prospective Multicenter Study. Pediatrics 2021; 148.
Olsen SJ, Winn AK, Budd AP, et al. Changes in Influenza and Other Respiratory Virus Activity During the COVID-19 Pandemic - United States, 2020-2021. MMWR Morb Mortal Wkly Rep 2021; 70:1013.
Foley DA, Yeoh DK, Minney-Smith CA, et al. The Interseasonal Resurgence of Respiratory Syncytial Virus in Australian Children Following the Reduction of Coronavirus Disease 2019-Related Public Health Measures. Clin Infect Dis 2021; 73:e2829.
Weekly respiratory pathogen surveillance report. South Africa (2020). Week 43. https://www.nicd.ac.za/wp-content/uploads/2020/10/Weekly-Respiratory-Pathogens-Report-Week-43-2020.pdf (Accessed on July 01, 2021).
Ohnishi T, Kawano Y. Resurgence of Respiratory Syncytial Virus Infection During an Atypical Season in Japan. J Pediatric Infect Dis Soc 2021; 10:982.
Halasa N, Zambrano LD, Amarin JZ, et al. Infants Admitted to US Intensive Care Units for RSV Infection During the 2022 Seasonal Peak. JAMA Netw Open 2023; 6:e2328950.
Hamid S, Winn A, Parikh R, et al. Seasonality of Respiratory Syncytial Virus - United States, 2017-2023. MMWR Morb Mortal Wkly Rep 2023; 72:355.
Pneumonia Etiology Research for Child Health (PERCH) Study Group. Causes of severe pneumonia requiring hospital admission in children without HIV infection from Africa and Asia: the PERCH multi-country case-control study. Lancet 2019; 394:757.
Wildenbeest JG, Billard MN, Zuurbier RP, et al. The burden of respiratory syncytial virus in healthy term-born infants in Europe: a prospective birth cohort study. Lancet Respir Med 2023; 11:341.
Jain S, Williams DJ, Arnold SR, et al. Community-acquired pneumonia requiring hospitalization among U.S. children. N Engl J Med 2015; 372:835.
Shi T, McAllister DA, O'Brien KL, et al. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study. Lancet 2017; 390:946.
Geoghegan S, Erviti A, Caballero MT, et al. Mortality due to Respiratory Syncytial Virus. Burden and Risk Factors. Am J Respir Crit Care Med 2017; 195:96.
Caballero MT, Bianchi AM, Nuño A, et al. Mortality Associated With Acute Respiratory Infections Among Children at Home. J Infect Dis 2019; 219:358.
Matias G, Taylor R, Haguinet F, et al. Estimates of mortality attributable to influenza and RSV in the United States during 1997-2009 by influenza type or subtype, age, cause of death, and risk status. Influenza Other Respir Viruses 2014; 8:507.
Byington CL, Wilkes J, Korgenski K, Sheng X. Respiratory syncytial virus-associated mortality in hospitalized infants and young children. Pediatrics 2015; 135:e24.
Tam J, Papenburg J, Fanella S, et al. Pediatric Investigators Collaborative Network on Infections in Canada Study of Respiratory Syncytial Virus-associated Deaths in Pediatric Patients in Canada, 2003-2013. Clin Infect Dis 2019; 68:113.
Article Statistics
Downloads
Copyright License
Copyright (c) 2025 Artikova Magina Akmalovna

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.


Medical Science
| Open Access |
DOI: