Premature skin aging is a complex, multifactorial process that results in structural and functional alterations of the skin. It is characterized as an accelerated aging process triggered by both endogenous and exogenous factors. The primary pathogenetic mechanism underlying premature skin aging is the formation of oxidative stress induced by ultraviolet (UV) radiation. This leads to the generation of reactive oxygen species (ROS), which oxidize lipids, inactivate components of the extracellular matrix, and degrade collagen, elastin, and hyaluronic acid, as well as cause direct DNA damage. The purpose of this study is to systematically analyze scientific data on the effects of bioactive forms of vitamin C, hyaluronate, and their combination on the processes that contribute to premature skin aging. The findings confirm that the antioxidant properties of bioactive vitamin C, combined with the hydrophilic environment created by hyaluronate in the extracellular matrix, have a beneficial effect in preventing premature skin aging. However, the potential for their synergistic interaction requires further investigation.

vitamin C, hyaluronic acid, hyaluronate, antioxidants, oxidative stress, skin aging, photoaging, extracellular matrix, collagen, ultraviolet radiation

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