Articles | Open Access | DOI: https://doi.org/10.37547/tajmspr/Volume07Issue04-02

Comparison of Hearing loss in Children 3 months to 3 years Old with and without Risk Factors

Iqra Adrees , Clinical Audiologist, Audiology Centre, Lahore, Pakistan.
Nadeem Mukhtar , Consultant Audiologist, Hearing Aid and CI specialist Coordinator Pakistan, Cochlear implant program, Pakistan.
Nauman M Shah , Consultant Audiologist, Hearing Aid & vestibular Specialist, Audiology Centre, Lahore, Pakistan.
Anum Nasrullah , Clinical Audiologist, Audiology Centre, Lahore, Pakistan

Abstract

Background: Babies in newborn intensive care units (NICU) are more expected to experience hearing loss due to a wide range of risk factors, such as prematurity, low birth weight, and hyperbilirubinemia. Effects of hearing impairment among children include poor consequences in speech, linguistics, social interaction, education, intelligence abilities, and overall well-being of life. Aims & Objective: The purpose of our research was to find out the comparison of hearing loss in children 3 months to 3 years old, with and without risk factors. Methodology: Our study was conducted at the Audiology Centre, Lahore. Children age range from 3 months to 3 years; both male and female genders were included in our study. Detailed history-taking of patients was done. We did an audiological evaluation through TEOAEs, Immittance Audiometry, and Auditory Brainstem Response Audiometry in 98 children (49 in each group) with risk factors indicated by the Joint Committee on Infant Hearings (JCIH) (2007) and without risk factors. Every parent gave their consent to participate in the study. Results & Findings: The total number of children was 98; 59.6% were male and 39.4% were female. The mean age of the children was 1.86±0.73.  In the risk factor group, 77.6% of children had referred TEOAEs, while in the children without risk factor group, 34.7% of children had TEOAEs referred. In the risk factor group, 77.6% of children had hearing loss, while in the without risk factor group, 36.7% of children had hearing loss. The Wilcoxon Signed Ranks test reveals a statistically significant difference (P < 0.05) between the hearing impaired with and without risk factor groups. Conclusion: Our study reveals significant at-risk factors for childhood hearing impairment, including consanguinity, prematurity, NICU stays for more than 5 days, family history of hearing loss, meningitis, and low birth weight. This current study recommends mandatory neonatal hearing screening for early identification and management. Advances in technology and evidence-based public health approaches can help recognize, treat, and cure hearing loss.

Keywords

Hearing loss, Children, JCIH Risk factors, OAEs, ABR, Tympanometry, NICU

References

Dimitrov L, Gossman W. Pediatric Hearing Loss. 2023 Jun 2. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30855869.

Lieu JEC, Kenna M, Anne S, Davidson L. Hearing Loss in Children: A Review. JAMA. 2020 Dec 1;324(21):2195-2205. doi: 10.1001/jama.2020.17647. PMID: 33258894.

Brown CS, Emmett SD, Robler SK, Tucci DL. Global Hearing Loss Prevention. Otolaryngol Clin North Am. 2018 Jun;51(3):575-592. doi: 10.1016/j.otc.2018.01.006. Epub 2018 Mar 7. PMID: 29525388.

Hearing loss: an important global health concern. Lancet. 2016 Jun 11;387(10036):2351. doi: 10.1016/S0140-6736(16)30777-2. PMID: 27312288.

Aiyer RG, Parikh B. Evaluation of auditory brainstem responses for hearing screening of high-risk infants. Indian J Otolaryngol Head Neck Surg. 2009 Mar;61(1):47-53. doi: 10.1007/s12070-009-0034-4. Epub 2009 Mar 31. PMID: 23120604; PMCID: PMC3450124.

Alanazi AA, Nicholson N. Audiology and Speech-Language Pathology Simulation Training on the 1-3-6 Early Hearing Detection and Intervention Timeline. Am J Audiol. 2019 Jun 10;28(2):348-361. doi: 10.1044/2019_AJA-18-0185. Epub 2019 May 16. PMID: 31095403.

Biswas AK, Goswami SC, Baruah DK, Tripathy R. The potential risk factors and the identification of hearing loss in infants. Indian J Otolaryngol Head Neck Surg. 2012 Sep;64(3):214-7. doi: 10.1007/s12070-011-0307-6. Epub 2011 Sep 4. PMID: 23998022; PMCID: PMC3431521.

Karaca CT, Oysu C, Toros SZ, Naiboǧlu B, Verim A. Is hearing loss in infants associated with risk factors? Evaluation of the frequency of risk factors. Clin Exp Otorhinolaryngol. 2014 Dec;7(4):260-3. doi: 10.3342/ceo.2014.7.4.260. Epub 2014 Nov 14. PMID: 25436043; PMCID: PMC4240481.

Deltenre P, Van Maldergem L. Hearing loss and deafness in the pediatric population: causes, diagnosis, and rehabilitation. Handb Clin Neurol. 2013;113:1527-38. doi: 10.1016/B978-0-444-59565-2.00023-X. PMID: 23622376.

Hajare P, Mudhol R. A Study of JCIH (Joint Commission on Infant Hearing) Risk Factors for Hearing Loss in Babies of NICU and Well Baby Nursery at a Tertiary Care Center. Indian J Otolaryngol Head Neck Surg. 2022 Dec;74(Suppl 3):6483-6490. doi: 10.1007/s12070-021-02683-w. Epub 2021 Jun 15. PMID: 34150585; PMCID: PMC8205201.

Abu-Shaheen A, Al-Masri M, El-Bakri N, Batieha A, Nofal A, Abdelmoety D. Prevalence and risk factors of hearing loss among infants in Jordan: initial results from universal neonatal screening. Int J Audiol. 2014 Dec;53(12):915-20. doi: 10.3109/14992027.2014.944275. Epub 2014 Sep 1. PMID: 25177764.

Bener A, Eihakeem AA, Abdulhadi K. Is there any association between consanguinity and hearing loss. Int J Pediatr Otorhinolaryngol. 2005 Mar;69(3):327-33. doi: 10.1016/j.ijporl.2004.10.004. Epub 2004 Dec 1. PMID: 15733591.

Ali A, Tabouni M, Kizhakkedath P, Baydoun I, Allam M, John A, Busafared F, Alnuaimi A, Al-Jasmi F, Alblooshi H. Spectrum of genetic variants in bilateral sensorineural hearing loss. Front Genet. 2024 Feb 12;15:1314535. doi: 10.3389/fgene.2024.1314535. PMID: 38410152; PMCID: PMC10894970.

The Lancet, ISSN: 0140-6736, Vol: 397, Issue: 10278, Page: 996-1009 Publication Year2021

Girotto G, Mezzavilla M, Abdulhadi K, Vuckovic D, Vozzi D, Khalifa Alkowari M, Gasparini P, Badii R. Consanguinity and hereditary hearing loss in Qatar. Hum Hered. 2014;77(1-4):175-82. doi: 10.1159/000360475. Epub 2014 Jul 29. PMID: 25060281

Leal B, Lopes AC, Peixoto D, Correia L, Almiro MM, Vilar J, Azevedo ML, Bicho MA. Parental Consanguinity and Risk for Childhood Hearing Loss: A Retrospective Cohort Study. Acta Med Port. 2023 May 2;36(5):336-342. doi: 10.20344/amp.18607. Epub 2023 Feb 17. PMID: 36799720.

Sanyelbhaa H, Kabel A, Abo El-Naga HAE, Sanyelbhaa A, Salem H. The risk ratio for development of hereditary sensorineural hearing loss in consanguineous marriage offspring. Int J Pediatr Otorhinolaryngol. 2017 Oct;101:7-10. doi: 10.1016/j.ijporl.2017.07.020. Epub 2017 Jul 19. PMID: 28964313.

Khabori MA, Patton MA. Consanguinity and deafness in Omani children. Int J Audiol. 2008 Jan;47(1):30-3. doi: 10.1080/14992020701703539. PMID: 18196484.

Dia Y, Loum B, Dieng YJKB, Diop JPD, Adadey SM, Aboagye ET, Ba SA, Touré AA, Niang F, Diaga Sarr P, Tidiane Ly CA, Sène ARG, Kock C, Bassier R, Popel K, Ndiaye Diallo R, Wonkam A, Diallo BK. Childhood Hearing Impairment in Senegal. Genes (Basel). 2023 Feb 23;14(3):562. doi: 10.3390/genes14030562. PMID: 36980833; PMCID: PMC10048257.

Valido Quintana M, Oviedo Santos Á, Borkoski Barreiro S, Santana Rodríguez A, Ramos Macías Á. Evaluation of family history of permanent hearing loss in childhood as a risk indicator in universal screening. Acta Otorrinolaringol Esp (Engl Ed). 2017 May-Jun;68(3):157-163. English, Spanish. doi: 10.1016/j.otorri.2016.08.001. Epub 2016 Oct 21. PMID: 27776808.

le Roux T, Swanepoel de W, Louw A, Vinck B, Tshifularo M. Profound childhood hearing loss in a South Africa cohort: risk profile, diagnosis and age of intervention. Int J Pediatr Otorhinolaryngol. 2015 Jan;79(1):8-14. doi: 10.1016/j.ijporl.2014.09.033. Epub 2014 Oct 28. PMID: 25455028.

Hrnčić N. Identification of risk factors for hearing impairment in newborns: a hospital based study. Med Glas (Zenica). 2018 Feb 1;15(1):29-36. doi: 10.17392/943-18. PMID: 29549688.

Salvago P, Martines E, Martines F. Prevalence and risk factors for sensorineural hearing loss: Western Sicily overview. Eur Arch Otorhinolaryngol. 2013 Nov;270(12):3049-56. doi: 10.1007/s00405-013-2379-2. Epub 2013 Feb 10. PMID: 23397062.

Frezza S, Tiberi E, Corsello M, Priolo F, Cota F, Catenazzi P, Conti G, Costa S, Vento G. Hearing Loss and Risk Factors in Very Low Birth Weight Infants. J Clin Med. 2023 Dec 8;12(24):7583.

Nair V, Janakiraman S, Whittaker S, Quail J, Foster T, Loganathan PK. Permanent childhood hearing impairment in infants admitted to the neonatal intensive care unit: nested case-control study. Eur J Pediatr. 2021 Jul;180(7):2083-2089. doi: 10.1007/s00431-021-03983-7. Epub 2021 Feb 16. PMID: 33594542.

Martínez-Cruz CF, Poblano A, Fernández-Carrocera LA. Risk factors associated with sensorineural hearing loss in infants at the neonatal intensive care unit: 15-year experience at the National Institute of Perinatology (Mexico City). Arch Med Res. 2008 Oct;39(7):686-94. doi: 10.1016/j.arcmed.2008.06.004. PMID: 18760198.

Boskabadi H, Zakerihamidi M, Moradi A, Bakhshaee M. Risk Factors for Sensorineural Hearing Loss in Neonatal Hyperbilirubinemia. Iran J Otorhinolaryngol. 2018 Jul;30(99):195-202. PMID: 30083525; PMCID: PMC6064763.

Jeong J, Youk TM, Oh J, Eo TS, Choi HS. Neonatal and maternal risk factors for hearing loss in children based on population-based data of Korea. Int J Pediatr Otorhinolaryngol. 2021 Aug;147:110800. doi: 10.1016/j.ijporl.2021.110800. Epub 2021 Jun 12. PMID: 34147905.

Han Y, Li S, Song Y, Sun J, Yan W, Wang J, Gao X, Li X, Ren C, Zhao Q. Risk factors for infant hearing loss: a meta-analysis. Eur J Pediatr. 2024 Mar 8. doi: 10.1007/s00431-024-05498-3. Epub ahead of print. PMID: 38456989.

Borkoski-Barreiro SA, Falcón-González JC, Limiñana-Cañal JM, Ramos-Macías A. Evaluation of very low birth weight (≤ 1,500 g) as a risk indicator for sensorineural hearing loss. Acta Otorrinolaringol Esp. 2013 Nov-Dec;64(6):403-8. English, Spanish. doi: 10.1016/j.otorri.2013.05.002. Epub 2013 Jul 27. PMID: 23896490.

Zhu X, Lei X, Dong W. Change to Hearing Loss-Related Risks and Screening in Preterm Infants. Am J Perinatol. 2022 Apr;39(5):501-512. doi: 10.1055/s-0040-1717071. Epub 2020 Sep 29. PMID: 32992352.

Pan L, Fang X, Chen H, Zhai F, Chen J. Risk factors for hearing loss in neonates admitted to neonatal intensive care units. J Laryngol Otol. 2022 Dec;136(12):1196-1202. doi: 10.1017/S002221512100414X. Epub 2021 Dec 20. PMID: 36210183.

Zeeshan F, Bari A, Dugal MN, Saeed F. Hearing impairment after acute bacterial meningitis in children. Pak J Med Sci. 2018 May-Jun;34(3):655-659. doi: 10.12669/pjms.343.14373. PMID: 30034433; PMCID: PMC6041555

Hardani AK, Goodarzi E, Delphi M, Badfar G. Prevalence and Risk Factors for Hearing Loss in Neonates Admitted to the Neonatal Intensive Care Unit: A Hospital Study. Cureus. 2020 Oct 27;12(10):e11207. doi: 10.7759/cureus.11207. PMID: 33269138; PMCID: PMC7704024.

Newman CW, Sandridge SA. Hearing loss is often undiscovered, but screening is easy. Cleve Clin J Med. 2004 Mar;71(3):225-32. doi: 10.3949/ccjm.71.3.225. PMID: 15055245.

Bielecki I, Horbulewicz A, Wolan T. Risk factors associated with hearing loss in infants: an analysis of 5282 referred neonates. Int J Pediatr Otorhinolaryngol. 2011 Jul;75(7):925-30. doi: 10.1016/j.ijporl.2011.04.007. Epub 2011 May 14. PMID: 21571377.

Kenna MA. Medical management of childhood hearing loss. Pediatr Ann. 2004 Dec;33(12):822-32. doi: 10.3928/0090-4481-20041201-08. PMID: 15615309.

Article Statistics

Copyright License

Download Citations

How to Cite

Iqra Adrees, Nadeem Mukhtar, Nauman M Shah, & Anum Nasrullah. (2025). Comparison of Hearing loss in Children 3 months to 3 years Old with and without Risk Factors. The American Journal of Medical Sciences and Pharmaceutical Research, 7(04), 07–15. https://doi.org/10.37547/tajmspr/Volume07Issue04-02