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DOI: Effects Of F-18 On KCL And Phenylephrine - Induced Contractions Of Rat Aorta
Abdisalim Zaripov , Karakalpak State University Named After Berdakh, Nukus, Uzbekistan Adilbay Esimbetov , Karakalpak State University Named After Berdakh, Nukus, Uzbekistan Pulat Usmanov , Institute Of Biophysics And Biochemistry, National University Of Uzbekistan, Tashkent, Uzbekistan Durdona Shokirova , Institute Of Biophysics And Biochemistry, National University Of Uzbekistan, Tashkent, Uzbekistan Sherzod Zhurakulov , Institute Of Chemistry Of Plant Substances, Uzbek Academy Of Sciences, Tashkent, UzbekistanAbstract
The mechanism of action of the alkaloid 1-(2´-bromine-4´,5´-dimethoxyphenyl) - 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (F-18) on the functional activity of smooth muscle cells of the rat aorta was studied. Isometric contraction activity was recorded using a Grass FT – 03 (Grass Instrument, USA) mechanotron. The relaxant effect of the F-18 alkaloid was found to be associated with blockade of Ca2 + (IP3R) channels in the SR, along with voltage- dependent and receptor-operated Ca2+channels in the aorta smooth muscle cell plasmalemma.
Keywords
Rat aorta, vascular smooth muscle cells, vasorelaxation, Ca2 -channel
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