Background: One of the reasons for the high prevalence and mortality in COPD is considered to be untimely unrecognized and unresolved causes of the development of COPD. At the same time, early detection of COPD and treatment started as early as possible slow down the progression of the disease.

Material and methods: 80 patients with COPD were under observation, among whom there were 51 (63.7%) men and 29 (36.3%) women. The average age of the patients was 47±1.5 years. A general blood test was performed according to standard methods.  Grade 1 COPD severity was diagnosed in 25 patients, grade II – in 28 and grade III – in 27 patients.

Results: Serum cytokines and chemokines can disrupt the main stages of hematopoiesis; possible mechanisms of anemia in COPD are shortening of erythrocyte apoptosis, impaired mobilization and utilization of iron, and impaired bone marrow response to erythropoietin.When studying ferrokinetics indicators in COPD patients with various degrees of severity, it was noted that as the patients’ condition worsens, the hematological status changes with a shift towards anemia.

Conclusion: According to its genesis, anemia in patients with COPD belongs to the so-called, anemia of chronic diseases and can be considered a definite risk factor for the progression of COPD.

COPD, anemia, ferrokinetic

Hurst JR, Han MK, Singh B, Sharma S, Kaur G, de Nigris E, Holmgren U, Siddiqui MK. Prognostic risk factors for moderate-to-severe exacerbations in patients with chronic obstructive pulmonary disease: a systematic literature review. Respir Res. 2022 Aug 23;23(1):213. doi: 10.1186/s12931-022-02123

De Miguel-Díez J, Fernández-Villar A, Doña Díaz E, Padilla Bernáldez M, Trillo-Calvo E, Molina París J, Barrecheguren M, Valero Pérez JM, Ramírez Prieto MT. Chronic Obstructive Lung Disease: Treatment Guidelines and Recommendations for Referral and Multidisciplinary Continuity of Care. J Clin Med. 2024 Jan 5;13(2):303. doi: 10.3390/jcm13020303.

Wang C, Wang L, Hou L, Lu H, Shang S. Determinants of Self-Rated Health Among Middle-Aged and Elderly Patients with COPD: The China Health and Retirement Longitudinal Study. Clinical Nursing Research. 2022;31(1):80-88. doi:10.1177/10547738211018818

Sanja Stanojevic, David A. Kaminsky, Martin R. Miller, Bruce Thompson, Andrea Aliverti, Igor Barjaktarevic, Brendan G. Cooper, Bruce Culver, Eric Derom, Graham L. Hall, Teal S. Hallstrand, Joerg D. Leuppi, Neil MacIntyre, Meredith McCormack, Margaret Rosenfeld, Erik R. Swenson European Respiratory Journal 2022 60: 2101499; DOI: 10.1183/13993003.01499-2021

Wu, P., Jiang, Yq., Si, Fl. et al. Pharmaceutical treatment status of patients with COPD in the community based on medical Internet of Things: a real-world study. npj Prim. Care Respir. Med. 34, 10 (2024). https://doi.org/10.1038/s41533-024-00371-0

Ane Arbillaga-Etxarri, Elena Gimeno-Santos, Anael Barberan-Garcia, Eva Balcells, Marta Benet, Eulàlia Borrell, Nuria Celorrio, Anna Delgado, Carme Jané, Alicia Marin, et al, European Respiratory Journal 2018 52: 1800063; DOI: 10.1183/13993003.00063-2018

Ali Ahmadi, Hamid Ghaedi, Jafar Salimian, Sadegh Azimzadeh Jamalkandi, Mostafa Ghanei, Association between chronic obstructive pulmonary disease and interleukins gene variants: A systematic review and meta-analysis, Cytokine, Volume 117, 2019, Pages 65-71, ISSN 1043-4666, https://doi.org/10.1016/j.cyto.2019.02.003.

Patel N. An update on COPD prevention, diagnosis, and management: The 2024 GOLD Report. Nurse Pract. 2024 Jun 1;49(6):29-36. doi: 10.1097/01.NPR.0000000000000180.

Cireli, Emel, and Aydan Mertoğlu. 2022. “The Impact of Anemia on the Mortality of COPD Patients Hospitalized for Acute Exacerbation Resulting in Respiratory Failure”. Monaldi Archives for Chest Disease 93 (2). https://doi.org/10.4081/monaldi.2022.2254.