Medicinal Efficacy of Punica Granatum Pericarp Derivatives in A Small Teleost Model: Combined Botanical and Behavioral Evaluation

The exploration of plant-derived bioactive compounds has gained substantial momentum in contemporary biomedical research due to their therapeutic potential, cost-effectiveness, and reduced adverse effects. Among these, Punica granatum (pomegranate) has emerged as a significant source of phytochemicals, particularly within its pericarp, which is often considered an agro-industrial byproduct. This study investigates the medicinal efficacy of Punica granatum pericarp derivatives using a small teleost model, focusing on an integrative evaluation of phytochemical composition and neurobehavioral outcomes. The research addresses the growing need for alternative therapeutic agents derived from natural products and evaluates their biological activity within a controlled experimental framework.

The study employs a multidisciplinary methodology combining phytochemical profiling, behavioral assays, and functional analysis. Phytochemical constituents such as polyphenols, flavonoids, tannins, and alkaloids are examined for their pharmacological relevance. Behavioral assessments in the teleost model are used to evaluate neuroprotective, anxiolytic, and cognitive-enhancing effects. The integration of botanical analysis with behavioral science enables a comprehensive understanding of the bioactivity of pericarp derivatives.

Findings indicate that Punica granatum pericarp extracts demonstrate significant bioactivity, including antioxidant, antimicrobial, and neurobehavioral modulation effects. These findings are consistent with prior research highlighting the therapeutic potential of pomegranate peel extract in zebrafish models (Agarwal and Usharani, 2026). The study further identifies mechanistic pathways through which these compounds exert their effects, including oxidative stress reduction and modulation of neurotransmitter systems.

The results contribute to the expanding body of knowledge on plant-based therapeutics and support the potential application of Punica granatum derivatives in pharmaceutical and nutraceutical domains. Limitations include variability in phytochemical composition and challenges in translating findings to human systems. Future research should focus on clinical validation and advanced molecular investigations.

Punica granatum, pericarp extract, phytochemicals, teleost model

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