This article analyzes the processes associated with calcium in nerve cells. Pathological changes in the nerve cells negatively affect the natural physiological processes in the human organism. Elevated intracellular Са²⁺ concentrations are involved in neurotransmitter release, synapse plasticity, enzyme activation, and gene expression. Of great importance is the question of studying the mechanisms of pharmacological correction using biologically active substances in pathological conditions in the brain in the synaptosomes, Са²⁺ transport.

Neurons, calcium,

Audesirk G. Armstrong D., van den Maagdenberg A. M., Atchison W., Shafer T., Fletcher C. Calcium channels: critical targets of toxicants and diseases // Environmental health perspectives. – 2000. – V. 108. – №. 12. – С. 1215-1218.

Azevedo F.A. Carvalho L.R., Grinberg L.T., Farfel J.M., Ferretti R.E., Leite R.E., Herculano‐Houzel S. Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled‐up primate brain // Journal of Comparative Neurology. – 2009. – V. 513. – №. 5. – С. 532-541.

Antkiewicz-Michaluk L. Voltage-operated calcium channels: characteristics and their role in the mechanism of action of psychotropic drugs // Polish journal of pharmacology. – 1999. – V. 51. – №. 2. – С. 179-186.

Berridge M.J. Elementary and global aspects of calcium signalling // Journal of experimental biology. – 1997. – V. 200. – №. 2. – С. 315-319.

Burre J. Sharma M., Tsetsenis T., Buchman V., Etherton M. R., Sudhof T. C. α-Synuclein promotes SNARE-complex assembly in vivo and in vitro // Science. – 2010. – V. 329. – №. 5999. – С. 1663-1667.

Bucurenciu I., Bischofberger J., Jonas P. A small number of open Ca 2+ channels trigger transmitter release at a central GABAergic synapse // Nature neuroscience. – 2010. – V. 13. – №. 1. – С. 19-21.

Brini M. Cali T., Ottolini D., Carafoli E. Neuronal calcium signaling: function and dysfunction // Cellular and molecular life sciences. – 2014. – V. 71. – №. 15. – С. 2787-2814.

Catterall W.A. Voltage-gated calcium channels // Cold Spring Harbor perspectives in biology. – 2011. –V. 3. – №. 8. – С. 1-24

Denny M.F., Atchison W.D. Mercurial-induced alterations in neuronal divalent cation homeostasis // Neurotoxicology. – 1996. – V. 17. – №. 1. – С. 47.

Fransson A., Ruusala A., Aspenstrom P. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis // Journal of Biological Chemistry. – 2003. – V. 278. – №. 8. – С. 6495-6502

Ghisleni G. Porciuncula L. O., Cimarosti H., Rocha J.B.T., Salbego C.G., Souza D.O. Diphenyl diselenide protects rat hippocampal slices submitted to oxygen–glucose deprivation and diminishes inducible nitric oxide synthase immunocontent // Brain research. – 2003. – V. 986. – №. 1-2. – С. 196-199.

Gyorffy B.A., Toth V., Torok G., Gulyassy P., Kovacs R. A., Vadaszi H., Drahos L. Synaptic mitochondrial dysfunction and septin accumulation are linked to complement-mediated synapse loss in an Alzheimer’s disease animal model // Cellular and Molecular Life Sciences. – 2020. – С. 1-16.

Hardingham G. E., Bading H. Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders // Nature Reviews Neuroscience. – 2010. – V. 11. – №. 10. – С. 682-696.

Jhou J.F., Tai H.C. The study of postmortem human synaptosomes for understanding Alzheimer’s disease and other neurological disorders: a review // Neurology and therapy. – 2017. – V. 6. – №. 1. – С. 57-68.

Khoshimov N.N., Rakhimov R.N., Akhmedova G.B., Azizov V.G. Investigation of the effect of polyphenol euphorbin on the transport of L Glutamate and calcium channels to synaptosomes of rat brain // European Journal of Medicine. – 2018. – №. 6. – С. 72-82.

Kiryushko D., Novitskaya V., Soroka V., Klingelhofer J., Lukanidin E., Berezin V., Bock E. Molecular mechanisms of Ca2+ signaling in neurons induced by the S100A4 protein // Molecular and cellular biology. – 2006. – V. 26. – №. 9. – С. 3625-3638.

Lee K. S. et al. Altered ER–mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models // Proceedings of the National Academy of Sciences. – 2018. – V. 115. – №. 38. – С. E8844-E8853

Marambaud P., Dreses-Werringloer U., Vingtdeux V. Calcium signaling in neurodegeneration // Molecular neurodegeneration. – 2009. – V. 4. – №. 1. – С. 1-15.

Mattson M.P., Chan S.L. Neuronal and glial calcium signaling in Alzheimer’s disease // Cell calcium. – 2003. – V. 34. – №. 4-5. – С. 385-397.

Mayford M., Siegelbaum S.A., Kandel E.R. Synapses and memory storage // Cold Spring Harbor perspectives in biology. – 2012. – Т. 4. – №. 6. – С. 1-19.

Murphy K.M. Introduction to Synaptosomes //Synaptosomes. – Humana Press, New York, 2018. – С. 3-6.

Moretto M.B., Funchal C., Zeni G., Pessoa-Pureur R., Rocha J.B.T. Selenium compounds prevent the effects of methylmercury on the in vitro phosphorylation of cytoskeletal proteins in cerebral cortex of young rats // Toxicological Sciences. – 2005. – V. 85. – №. 1. – С. 639-646.

Napper R.M.A., Harvey R.J. Number of parallel fiber synapses on an individual Purkinje cell in the cerebellum of the rat // Journal of Comparative Neurology. – 1988. – V. 274. – №. 2. – С. 168-177.

Nogueira C.W., Zeni G., Rocha J.B.T. Organoselenium and organotellurium compounds: toxicology and pharmacology // Chemical Reviews. – 2004. – V. 104. – №. 12. – С. 6255-6286.

Nikonenko I. Bancila M., Bloc A., Muller D., Bijlenga P. Inhibition of T-type calcium channels protects neurons from delayed ischemia-induced damage // Molecular pharmacology. – 2005. – V. 68. – №. 1. – С. 84-89.

Parnham M., Sies H. Ebselen: prospective therapy for cerebral ischaemia // Expert opinion on investigational drugs. – 2000. – V. 9. – №. 3. – С. 607-619.

Prakriya M., Feske S., Gwack Y., Srikanth S., Rao A., Hogan P. G. Orai1 is an essential pore subunit of the CRAC channel // Nature. – 2006. – V. 443. – №. 7108. – С. 230-233.

Porciuncula L.O., Rocha J.B.T., Boeck C.R., Vendite D., Souza D.O. Ebselen prevents excitotoxicity provoked by glutamate in rat cerebellar granule neurons // Neuroscience letters. – 2001. – V. 299. – №. 3. – С. 217-220.

Prince M. Wimo A., Guerchet M., Ali G.C., Wu Y.T., Prina M. The global impact of dementia // World Alzheimer Report. – 2015. – С. 1-82.

Rossato J. I. Zeni G., Mello C. F., Rubin M. A., Rocha J. B. Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat // Neuroscience letters. – 2002. – V. 318. – №. 3. – С. 137-140.

Saitsu H. Kato M., Mizuguchi T., Hamada K., Osaka H., Tohyama J., Okada I. De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy // Nature genetics. – 2008. – V. 40. – №. 6. – С. 782-788.

Sudhof T. C. Neurotransmitter release: the last millisecond in the life of a synaptic vesicle //Neuron. – 2013. – V. 80. – №. 3. – С. 675-690.

Sudhof T. C. Neuroligins and neurexins link synaptic function to cognitive disease //Nature. – 2008. – V. 455. – №. 7215. – С. 903-911.

Stangherlin E.C. Favero A.M., Zeni G., Rocha J.B.T., Nogueira C.W. Teratogenic vulnerability of Wistar rats to diphenyl ditelluride // Toxicology. – 2005. – V. 207. – №. 2. – С. 231-239.

Vinayagam D. Mager T., Apelbaum A., Bothe A., Merino F., Hofnagel O., Raunser S. Electron cryo-microscopy structure of the canonical TRPC4 ion channel // eLife. – 2018. – V. 7. – С. 1-23.

Whittaker V.P. Thirty years of synaptosome research // Journal of neurocytology. – 1993. – V. 22. – №. 9. – С. 735-742.

Wu J. Yan Z., Li Z., Yan C., Lu S., Dong M., Yan N. Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution // Nature. – 2016. – V. 537. – №. 7619. – С. 191-196.

Yan S.F., Akhter F., Sosunov A.A., Yan S.S. Identification and characterization of Amyloid-β accumulation in synaptic mitochondria // Amyloid Proteins. – Humana Press, New York, 2018. – С. 415-433.

Yamaguchi T. Sano K., Takakura K., Saito I., Shinohara Y., Asano T., Yasuhara H. Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial // Stroke. – 1998. – V. 29. – №. 1. – С. 12-17.

https://www.ncbi.nlm.nih.gov/Structure/icn3d/full.html?showanno=1&mmdbid=143055

https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=254820

Audesirk G. Armstrong D., van den Maagdenberg A. M., Atchison W., Shafer T., Fletcher C. Calcium channels: critical targets of toxicants and diseases // Environmental health perspectives. – 2000. – V. 108. – №. 12. – С. 1215-1218.

Azevedo F.A. Carvalho L.R., Grinberg L.T., Farfel J.M., Ferretti R.E., Leite R.E., Herculano‐Houzel S. Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled‐up primate brain // Journal of Comparative Neurology. – 2009. – V. 513. – №. 5. – С. 532-541.

Antkiewicz-Michaluk L. Voltage-operated calcium channels: characteristics and their role in the mechanism of action of psychotropic drugs // Polish journal of pharmacology. – 1999. – V. 51. – №. 2. – С. 179-186.

Berridge M.J. Elementary and global aspects of calcium signalling // Journal of experimental biology. – 1997. – V. 200. – №. 2. – С. 315-319.

Burre J. Sharma M., Tsetsenis T., Buchman V., Etherton M. R., Sudhof T. C. α-Synuclein promotes SNARE-complex assembly in vivo and in vitro // Science. – 2010. – V. 329. – №. 5999. – С. 1663-1667.

Bucurenciu I., Bischofberger J., Jonas P. A small number of open Ca 2+ channels trigger transmitter release at a central GABAergic synapse // Nature neuroscience. – 2010. – V. 13. – №. 1. – С. 19-21.

Brini M. Cali T., Ottolini D., Carafoli E. Neuronal calcium signaling: function and dysfunction // Cellular and molecular life sciences. – 2014. – V. 71. – №. 15. – С. 2787-2814.

Catterall W.A. Voltage-gated calcium channels // Cold Spring Harbor perspectives in biology. – 2011. –V. 3. – №. 8. – С. 1-24

Denny M.F., Atchison W.D. Mercurial-induced alterations in neuronal divalent cation homeostasis // Neurotoxicology. – 1996. – V. 17. – №. 1. – С. 47.

Fransson A., Ruusala A., Aspenstrom P. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis // Journal of Biological Chemistry. – 2003. – V. 278. – №. 8. – С. 6495-6502

Ghisleni G. Porciuncula L. O., Cimarosti H., Rocha J.B.T., Salbego C.G., Souza D.O. Diphenyl diselenide protects rat hippocampal slices submitted to oxygen–glucose deprivation and diminishes inducible nitric oxide synthase immunocontent // Brain research. – 2003. – V. 986. – №. 1-2. – С. 196-199.

Gyorffy B.A., Toth V., Torok G., Gulyassy P., Kovacs R. A., Vadaszi H., Drahos L. Synaptic mitochondrial dysfunction and septin accumulation are linked to complement-mediated synapse loss in an Alzheimer’s disease animal model // Cellular and Molecular Life Sciences. – 2020. – С. 1-16.

Hardingham G. E., Bading H. Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders // Nature Reviews Neuroscience. – 2010. – V. 11. – №. 10. – С. 682-696.

Jhou J.F., Tai H.C. The study of postmortem human synaptosomes for understanding Alzheimer’s disease and other neurological disorders: a review // Neurology and therapy. – 2017. – V. 6. – №. 1. – С. 57-68.

Khoshimov N.N., Rakhimov R.N., Akhmedova G.B., Azizov V.G. Investigation of the effect of polyphenol euphorbin on the transport of L Glutamate and calcium channels to synaptosomes of rat brain // European Journal of Medicine. – 2018. – №. 6. – С. 72-82.

Kiryushko D., Novitskaya V., Soroka V., Klingelhofer J., Lukanidin E., Berezin V., Bock E. Molecular mechanisms of Ca2+ signaling in neurons induced by the S100A4 protein // Molecular and cellular biology. – 2006. – V. 26. – №. 9. – С. 3625-3638.

Lee K. S. et al. Altered ER–mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models // Proceedings of the National Academy of Sciences. – 2018. – V. 115. – №. 38. – С. E8844-E8853

Marambaud P., Dreses-Werringloer U., Vingtdeux V. Calcium signaling in neurodegeneration // Molecular neurodegeneration. – 2009. – V. 4. – №. 1. – С. 1-15.

Mattson M.P., Chan S.L. Neuronal and glial calcium signaling in Alzheimer’s disease // Cell calcium. – 2003. – V. 34. – №. 4-5. – С. 385-397.

Mayford M., Siegelbaum S.A., Kandel E.R. Synapses and memory storage // Cold Spring Harbor perspectives in biology. – 2012. – Т. 4. – №. 6. – С. 1-19.

Murphy K.M. Introduction to Synaptosomes //Synaptosomes. – Humana Press, New York, 2018. – С. 3-6.

Moretto M.B., Funchal C., Zeni G., Pessoa-Pureur R., Rocha J.B.T. Selenium compounds prevent the effects of methylmercury on the in vitro phosphorylation of cytoskeletal proteins in cerebral cortex of young rats // Toxicological Sciences. – 2005. – V. 85. – №. 1. – С. 639-646.

Napper R.M.A., Harvey R.J. Number of parallel fiber synapses on an individual Purkinje cell in the cerebellum of the rat // Journal of Comparative Neurology. – 1988. – V. 274. – №. 2. – С. 168-177.

Nogueira C.W., Zeni G., Rocha J.B.T. Organoselenium and organotellurium compounds: toxicology and pharmacology // Chemical Reviews. – 2004. – V. 104. – №. 12. – С. 6255-6286.

Nikonenko I. Bancila M., Bloc A., Muller D., Bijlenga P. Inhibition of T-type calcium channels protects neurons from delayed ischemia-induced damage // Molecular pharmacology. – 2005. – V. 68. – №. 1. – С. 84-89.

Parnham M., Sies H. Ebselen: prospective therapy for cerebral ischaemia // Expert opinion on investigational drugs. – 2000. – V. 9. – №. 3. – С. 607-619.

Prakriya M., Feske S., Gwack Y., Srikanth S., Rao A., Hogan P. G. Orai1 is an essential pore subunit of the CRAC channel // Nature. – 2006. – V. 443. – №. 7108. – С. 230-233.

Porciuncula L.O., Rocha J.B.T., Boeck C.R., Vendite D., Souza D.O. Ebselen prevents excitotoxicity provoked by glutamate in rat cerebellar granule neurons // Neuroscience letters. – 2001. – V. 299. – №. 3. – С. 217-220.

Prince M. Wimo A., Guerchet M., Ali G.C., Wu Y.T., Prina M. The global impact of dementia // World Alzheimer Report. – 2015. – С. 1-82.

Rossato J. I. Zeni G., Mello C. F., Rubin M. A., Rocha J. B. Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat // Neuroscience letters. – 2002. – V. 318. – №. 3. – С. 137-140.

Saitsu H. Kato M., Mizuguchi T., Hamada K., Osaka H., Tohyama J., Okada I. De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy // Nature genetics. – 2008. – V. 40. – №. 6. – С. 782-788.

Sudhof T. C. Neurotransmitter release: the last millisecond in the life of a synaptic vesicle //Neuron. – 2013. – V. 80. – №. 3. – С. 675-690.

Sudhof T. C. Neuroligins and neurexins link synaptic function to cognitive disease //Nature. – 2008. – V. 455. – №. 7215. – С. 903-911.

Stangherlin E.C. Favero A.M., Zeni G., Rocha J.B.T., Nogueira C.W. Teratogenic vulnerability of Wistar rats to diphenyl ditelluride // Toxicology. – 2005. – V. 207. – №. 2. – С. 231-239.

Vinayagam D. Mager T., Apelbaum A., Bothe A., Merino F., Hofnagel O., Raunser S. Electron cryo-microscopy structure of the canonical TRPC4 ion channel // eLife. – 2018. – V. 7. – С. 1-23.

Whittaker V.P. Thirty years of synaptosome research // Journal of neurocytology. – 1993. – V. 22. – №. 9. – С. 735-742.

Wu J. Yan Z., Li Z., Yan C., Lu S., Dong M., Yan N. Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution // Nature. – 2016. – V. 537. – №. 7619. – С. 191-196.

Yan S.F., Akhter F., Sosunov A.A., Yan S.S. Identification and characterization of Amyloid-β accumulation in synaptic mitochondria // Amyloid Proteins. – Humana Press, New York, 2018. – С. 415-433.

Yamaguchi T. Sano K., Takakura K., Saito I., Shinohara Y., Asano T., Yasuhara H. Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial // Stroke. – 1998. – V. 29. – №. 1. – С. 12-17.

https://www.ncbi.nlm.nih.gov/Structure/icn3d/full.html?showanno=1&mmdbid=143055

https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=254820

Audesirk G. Armstrong D., van den Maagdenberg A. M., Atchison W., Shafer T., Fletcher C. Calcium channels: critical targets of toxicants and diseases // Environmental health perspectives. – 2000. – V. 108. – №. 12. – С. 1215-1218.

Azevedo F.A. Carvalho L.R., Grinberg L.T., Farfel J.M., Ferretti R.E., Leite R.E., Herculano‐Houzel S. Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled‐up primate brain // Journal of Comparative Neurology. – 2009. – V. 513. – №. 5. – С. 532-541.

Antkiewicz-Michaluk L. Voltage-operated calcium channels: characteristics and their role in the mechanism of action of psychotropic drugs // Polish journal of pharmacology. – 1999. – V. 51. – №. 2. – С. 179-186.

Berridge M.J. Elementary and global aspects of calcium signalling // Journal of experimental biology. – 1997. – V. 200. – №. 2. – С. 315-319.

Burre J. Sharma M., Tsetsenis T., Buchman V., Etherton M. R., Sudhof T. C. α-Synuclein promotes SNARE-complex assembly in vivo and in vitro // Science. – 2010. – V. 329. – №. 5999. – С. 1663-1667.

Bucurenciu I., Bischofberger J., Jonas P. A small number of open Ca 2+ channels trigger transmitter release at a central GABAergic synapse // Nature neuroscience. – 2010. – V. 13. – №. 1. – С. 19-21.

Brini M. Cali T., Ottolini D., Carafoli E. Neuronal calcium signaling: function and dysfunction // Cellular and molecular life sciences. – 2014. – V. 71. – №. 15. – С. 2787-2814.

Catterall W.A. Voltage-gated calcium channels // Cold Spring Harbor perspectives in biology. – 2011. –V. 3. – №. 8. – С. 1-24

Denny M.F., Atchison W.D. Mercurial-induced alterations in neuronal divalent cation homeostasis // Neurotoxicology. – 1996. – V. 17. – №. 1. – С. 47.

Fransson A., Ruusala A., Aspenstrom P. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis // Journal of Biological Chemistry. – 2003. – V. 278. – №. 8. – С. 6495-6502

Ghisleni G. Porciuncula L. O., Cimarosti H., Rocha J.B.T., Salbego C.G., Souza D.O. Diphenyl diselenide protects rat hippocampal slices submitted to oxygen–glucose deprivation and diminishes inducible nitric oxide synthase immunocontent // Brain research. – 2003. – V. 986. – №. 1-2. – С. 196-199.

Gyorffy B.A., Toth V., Torok G., Gulyassy P., Kovacs R. A., Vadaszi H., Drahos L. Synaptic mitochondrial dysfunction and septin accumulation are linked to complement-mediated synapse loss in an Alzheimer’s disease animal model // Cellular and Molecular Life Sciences. – 2020. – С. 1-16.

Hardingham G. E., Bading H. Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders // Nature Reviews Neuroscience. – 2010. – V. 11. – №. 10. – С. 682-696.

Jhou J.F., Tai H.C. The study of postmortem human synaptosomes for understanding Alzheimer’s disease and other neurological disorders: a review // Neurology and therapy. – 2017. – V. 6. – №. 1. – С. 57-68.

Khoshimov N.N., Rakhimov R.N., Akhmedova G.B., Azizov V.G. Investigation of the effect of polyphenol euphorbin on the transport of L Glutamate and calcium channels to synaptosomes of rat brain // European Journal of Medicine. – 2018. – №. 6. – С. 72-82.

Kiryushko D., Novitskaya V., Soroka V., Klingelhofer J., Lukanidin E., Berezin V., Bock E. Molecular mechanisms of Ca2+ signaling in neurons induced by the S100A4 protein // Molecular and cellular biology. – 2006. – V. 26. – №. 9. – С. 3625-3638.

Lee K. S. et al. Altered ER–mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models // Proceedings of the National Academy of Sciences. – 2018. – V. 115. – №. 38. – С. E8844-E8853

Marambaud P., Dreses-Werringloer U., Vingtdeux V. Calcium signaling in neurodegeneration // Molecular neurodegeneration. – 2009. – V. 4. – №. 1. – С. 1-15.

Mattson M.P., Chan S.L. Neuronal and glial calcium signaling in Alzheimer’s disease // Cell calcium. – 2003. – V. 34. – №. 4-5. – С. 385-397.

Mayford M., Siegelbaum S.A., Kandel E.R. Synapses and memory storage // Cold Spring Harbor perspectives in biology. – 2012. – Т. 4. – №. 6. – С. 1-19.

Murphy K.M. Introduction to Synaptosomes //Synaptosomes. – Humana Press, New York, 2018. – С. 3-6.

Moretto M.B., Funchal C., Zeni G., Pessoa-Pureur R., Rocha J.B.T. Selenium compounds prevent the effects of methylmercury on the in vitro phosphorylation of cytoskeletal proteins in cerebral cortex of young rats // Toxicological Sciences. – 2005. – V. 85. – №. 1. – С. 639-646.

Napper R.M.A., Harvey R.J. Number of parallel fiber synapses on an individual Purkinje cell in the cerebellum of the rat // Journal of Comparative Neurology. – 1988. – V. 274. – №. 2. – С. 168-177.

Nogueira C.W., Zeni G., Rocha J.B.T. Organoselenium and organotellurium compounds: toxicology and pharmacology // Chemical Reviews. – 2004. – V. 104. – №. 12. – С. 6255-6286.

Nikonenko I. Bancila M., Bloc A., Muller D., Bijlenga P. Inhibition of T-type calcium channels protects neurons from delayed ischemia-induced damage // Molecular pharmacology. – 2005. – V. 68. – №. 1. – С. 84-89.

Parnham M., Sies H. Ebselen: prospective therapy for cerebral ischaemia // Expert opinion on investigational drugs. – 2000. – V. 9. – №. 3. – С. 607-619.

Prakriya M., Feske S., Gwack Y., Srikanth S., Rao A., Hogan P. G. Orai1 is an essential pore subunit of the CRAC channel // Nature. – 2006. – V. 443. – №. 7108. – С. 230-233.

Porciuncula L.O., Rocha J.B.T., Boeck C.R., Vendite D., Souza D.O. Ebselen prevents excitotoxicity provoked by glutamate in rat cerebellar granule neurons // Neuroscience letters. – 2001. – V. 299. – №. 3. – С. 217-220.

Prince M. Wimo A., Guerchet M., Ali G.C., Wu Y.T., Prina M. The global impact of dementia // World Alzheimer Report. – 2015. – С. 1-82.

Rossato J. I. Zeni G., Mello C. F., Rubin M. A., Rocha J. B. Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat // Neuroscience letters. – 2002. – V. 318. – №. 3. – С. 137-140.

Saitsu H. Kato M., Mizuguchi T., Hamada K., Osaka H., Tohyama J., Okada I. De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy // Nature genetics. – 2008. – V. 40. – №. 6. – С. 782-788.

Sudhof T. C. Neurotransmitter release: the last millisecond in the life of a synaptic vesicle //Neuron. – 2013. – V. 80. – №. 3. – С. 675-690.

Sudhof T. C. Neuroligins and neurexins link synaptic function to cognitive disease //Nature. – 2008. – V. 455. – №. 7215. – С. 903-911.

Stangherlin E.C. Favero A.M., Zeni G., Rocha J.B.T., Nogueira C.W. Teratogenic vulnerability of Wistar rats to diphenyl ditelluride // Toxicology. – 2005. – V. 207. – №. 2. – С. 231-239.

Vinayagam D. Mager T., Apelbaum A., Bothe A., Merino F., Hofnagel O., Raunser S. Electron cryo-microscopy structure of the canonical TRPC4 ion channel // eLife. – 2018. – V. 7. – С. 1-23.

Whittaker V.P. Thirty years of synaptosome research // Journal of neurocytology. – 1993. – V. 22. – №. 9. – С. 735-742.

Wu J. Yan Z., Li Z., Yan C., Lu S., Dong M., Yan N. Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution // Nature. – 2016. – V. 537. – №. 7619. – С. 191-196.

Yan S.F., Akhter F., Sosunov A.A., Yan S.S. Identification and characterization of Amyloid-β accumulation in synaptic mitochondria // Amyloid Proteins. – Humana Press, New York, 2018. – С. 415-433.

Yamaguchi T. Sano K., Takakura K., Saito I., Shinohara Y., Asano T., Yasuhara H. Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial // Stroke. – 1998. – V. 29. – №. 1. – С. 12-17.

https://www.ncbi.nlm.nih.gov/Structure/icn3d/full.html?showanno=1&mmdbid=143055

https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=254820

Audesirk G. Armstrong D., van den Maagdenberg A. M., Atchison W., Shafer T., Fletcher C. Calcium channels: critical targets of toxicants and diseases // Environmental health perspectives. – 2000. – V. 108. – №. 12. – С. 1215-1218.

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