Endogenous toxins are protein molecules whose content in the blood is determined by the destruction of cells. Not being normal components of blood plasma, they are subject to elimination from the bloodstream. Due to the accumulation of endogenous toxic substances, endogenous intoxication is a frequent complication of many acute and chronic diseases of the respiratory system. The present study revealed a significant increase in the markers of tubular lesion in children with pneumococcal pneumonia, even against the background of an uncomplicated course of the disease, which reflects the renal link of endotoxicosis syndrome.

Aim of the work: assessment of laboratory characteristics in patients with type 2 diabetes, depending on the risk of developing CI-AKI.

Materials and methods: The study included 56 patients with type 2 diabetes, the average age of the patients was 58 years, the CG consisted of 20 healthy volunteers. In most patients, the reason for which the endovascular radiopaque procedure (EVRCP) was performed was associated with atherosclerotic lesions: coronary artery disease, chronic lower limb ischemia (CLLI), atherosclerosis of the brachiocephalic arteries (BCA). EVRCP was performed on the vessels of the coronary basin, BCA, abdominal aorta and its branches, lower extremities. A retrospective analysis included a comparative analysis of two groups of patients with type 2 diabetes who underwent EVRCP: 29 patients who developed CI-AKI (CI-AKI+ group) and 27 patients in whom the post-procedure period was uneventful.

Results: The CI-AKI+ and CI-AKI- groups did not differ in nosological distribution: in both groups, half of the patients with EVRCP were performed due to the presence of coronary pathology (51.72% and 48.15%, respectively), the rest in patients it was comparable for CCI and CVD (27.59% and 20.69% in the CI-AKI+ group and 25.93% each in the CI-AKI- group).

Conclusion: Thus, based on the results of this study, it was possible to identify risk factors for the development of CI-AKI in patients with DM in the post-procedure period and to develop a scale that allows identifying DM patients predisposed to the development of CI-AKI as a hospital complication of endovascular interventional procedures, which is especially often observed in patients with DM.

Here are the results of the microscopic study of the shape and size of particles of 5 samples of amlodipine besylate substance of world manufacturers, registered and used in the pharmaceutical industry of Uzbekistan. Such characteristics as the size and shape of particles, as well as the crystalline state with the simultaneous photos have been evaluated. Factors of the shape of particles of the substance of the studied samples were calculated.

Primary hyperparathyroidism is one of the most common pathologies of the endocrine system, and therefore, our work reflects the results of surgical treatment of this pathology.

Essential hypertension can be defines as rise in blood pressure of unknown cause. It usually clusters with other risk factors such as ageing, weight gain, insulin resistance, diabetes and hyperlipidemia. Hypertension is common in developing countries, especially in urban area with sedentary lifestyle and low awareness, treatment and control. Though hypertension as a disease is not described in classical Ayurveda texts, there are many theories which can be adopted to treat. Data of four patients diagnosed with hypertension visiting OPD of Ayushakti Ayurveda Pvt Ltd were recruited for the study and the data of the same is analyzed in this case report.

This present study shows that this approach when administered in Hypertensive patients, they were able to significantly decrease the systolic as well as diastolic blood pressure without any toxic- or side effect. We were able to minimize the dose of antihypertensive modern molecules gradually when these polyherbal formulations were used along with Shirodhara and Heartdhara. With the help of this Ayurveda protocol hypertensive patients can be treated successfully by providing strength to the heart muscles.