MICROSCOPIC STUDIES OF THE SHAPE AND SIZE OF PARTICLES OF SAMPLES OF AMLODIPINE BESYLATE SUBSTANCES FROM SELECTED PHARMACEUTICAL MANUFACTURERS
A.Kh. Jalilov , Tashkent Pharmaceutical Institute, Uzbekistan V.R. Khaidarov , Tashkent Pharmaceutical Institute, UzbekistanAbstract
Here are the results of the microscopic study of the shape and size of particles of 5 samples of amlodipine besylate substance of world manufacturers, registered and used in the pharmaceutical industry of Uzbekistan. Such characteristics as the size and shape of particles, as well as the crystalline state with the simultaneous photos have been evaluated. Factors of the shape of particles of the substance of the studied samples were calculated.
Keywords
Amlodipine besylate substance, optical microscopy of particles, crystal forms
References
Decree of the President of the Republic of Uzbekistan, dated 21.01.2022, № DP-55. National database of legislation, 22.01.2022, № 06/22/55/0055, 06.04.2022, № 06/22/97/0275.
Decree of the President of the Republic of Uzbekistan, 28.01.2022, #DP-60. National legislative database, 29.01.2022, № 06/22/60/0082, 18.03.2022, № 06/22/89/0227.
Kobalava, J.D. Fixed combination of amlodipine, indapamide, and
perindopril: new horizons of antihypertensive therapy / J.D.
Kobalava, E.A. Troitskaya, N.E. Ezhova // Cardiology. -2017. - Т.57, №4. - С.79-88
Grassi, G. Neuroadrenergic abnormalities in hypertension and hypertension-related cardiovascular disease / G. Grassi // Hipertens Riesgo Vasc. - 2013. - №30 (2). - Р.70-74.
Mancia, G. Cardiovascular outcomes at different on-treatment blood pressures in the hypertensive patients of the VALUE trial. / G. Mancia [et al.] // Eur Heart J.-2016. -37(12). Р.955-964.
Park, K.T. Association between reduced arterial stiffness and preserved diastolic function of the left ventricle in middle-aged and elderly patients / K.T. Park [et al.] // J Clin Hypertens (Greenwich). - 2017. - 19(6). - Р.620-626.
Schiffrin, E.L. Vascular Remodeling in Hypertension: Mechanisms and Treatment / E.L. Schiffrin // Hypertension. - 2012. - №59. - Р.367-374.
European Pharmacopoeia 8th ed., Volume II, Part 1, P.2137-2139
State register of medicines, medical devices, and medical equipment permitted for use in medical practice. - 26th edition, revised, edited, and supplemented. 855 p. - MHW "MUXR PRESS". 2022.
State Pharmacopoeia of the Republic of Uzbekistan, 1st ed. 2466p. // AK "Sharq", Tashkent, 2021 g.
Daragan A.G. Physics of tablets and basic technological processes of tablets production: Review information //Chem. -pharm. industry. -1983. -№10. 25 p.
Ionova K., Velichkov E., Filipov I.L. Significance of particle size for some physical characteristics of ascorbic acid tablets//Pharmacy, Sofia. -1978. -Т.28, №4. -p.22-26.
Nesmiyan T.Y., Sayfiulin R.M. Possibility of drugs depending on their crystallographic structure // Proc. Dokl. III Congress of pharmacists of the Ukrainian Soviet Socialist Republic. - Kharkiv, 1979. -p.75.
Duru C., Delalone M., Jacob M. Effect of liant en granulation humide et compression de gelatins sans force en gelae on de faible pouvoir gelifiant//SJP Pharma. -1990. -V.6, №8. - P.560-566.
Jalilov A.H. Yurak kon-tomir kasalliklarida ishlaliladigan dori vositalarininig tarkibi va tekhnologii takomillashtirish imkoniyatlari. The Twenty-first Century - the Century of the Intellectual Generation. Tashkent, 2015, P.105-111.
Jalilov A.Kh., Khaidarov V.R. Amlodipine besilat va enalapril maleate capsulararinning tarkibi va tekhnologasi. Pharmaceutical Journal 2017 № 2 p.105-111.
Article Statistics
Copyright License
Copyright (c) 2023 The American Journal of Medical Sciences and Pharmaceutical Research

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.