We have studied the morphological, morphometric parameters of the liver of white rats. Against the background of polypharmacy, when using non-steroidal anti-inflammatory drugs, it was revealed in the structure of the liver, which led to various damage to the liver parenchyma. The simultaneous use of non-steroidal anti-inflammatory drugs leads to acute or chronic liver failure in rats. The longer the therapy for chronic diseases, the more pronounced morphological changes (necrosis, fibrosis, and cholestasis).

Oxytocin a nonapeptide of atomic mass 1007 daltons discharged in the paraventricular and supraoptic cores of the nerve center. Its receptors are broadly appropriated in the focal sensory system. Be that as it may, the social impacts of midway regulated oxytocin have gotten little consideration in view of accessibility of less data about its job in male psychobehavior. In the current review, we tried the impacts of ICV infusions of oxytocin on exploratory conduct in male rodents and mice embracing grounded open field test. The impacts were concentrated by considering dormancy time to investigate, prepping, raising, flat development, poop and pee as boundaries in exploratory social examinations. Organization of 2ml per creature reviewed dosages of oxytocin (1mg/ml, 2mg/ml and 4mg/ml) incited critical (P<0.01) expansion in exploratory conduct by the two rodents and mice in open field test. Taken together, the current review exhibits that focal infusion of oxytocin in male rodents and mice in portions (1mg/ml, 2mg/ml and 4mg/ml) upgrade investigation and works on friendly communication, recommending that oxytocin might be associated with certain parts of male psychosocial conduct.

The purpose of the study: development of the Program using ICT for the decreed contingent and the creation of a unified medical information and analytical system, at the stage of transition to compulsory medical insurance.

Materials and methods. Research methods: will be studied the following employees of school educational and district medical institutions (SHOU, RMU) who periodically underwent medical examination in the Kibray district of the Tashkent region.

Results and Discussions: The study found that in 2019, the Qibray District Medical Association Medical Commission examined only 4,992 workers or 4.3 percent (116061) of the able-bodied population of Qibray District, of which 29 were diagnosed with some form of the disease. Or only 0.58 percent of the diagnosed diseases are women.

Conclusions: based on an in-depth analysis of the contingent, further studies will create an electronic database on the categories, groups, age, disease and frequency of the contingent contingent in Qibray district of Tashkent region.

We studied macro and microscopic changes in kidney tissue against the background of polypharmacy when modeling renal pathology. It has been shown that the simultaneous use of more than 5 drugs has a nephrotoxic effect on the proximal renal tubules. On macroscopic examination, the kidneys were bean-shaped, the capsule was smooth; with the help of a magnifying glass, it was smooth, shiny, without visible differences. Microscopically, in the kidney tissue in the study group, some structural differences were revealed, the nature and severity of which depended on the type of active drug. In the glomerular apparatus of the kidneys of rats, focal infiltration of mesangial cells was noted. Moreover, in the direct tubules of the kidney apparatus, remarkable changes were not revealed. Thus, it was concluded that tubular damage leads to impaired tubular reabsorption, proteinuria, the morphological criteria of steatosis, and dysproteinosis of varying degrees.

Vaccination is a costly activity, as it involves coverage of a wide population. Methods to assess the effectiveness of immunoprophylaxis and the quality of preventive (anti-epidemic) measures are discussed in this context.

COVID-19, like other respiratory viruses, has extrapulmonary manifestations. In particular, exposure to the virus leads to damage to the cardiovascular system (CVS). The review presents the current problems of the combination of the new coronavirus infection COVID-19 and cardiovascular diseases. The results of a few clinical studies and individual clinical cases, illustrating the difficulties of managing patients with viral infection and comorbidities, are discussed. The combination of COVID-19 with cardiovascular diseases creates additional difficulties in diagnostics, determining priority tactics, changing the routing orders of patients with emergencies, and choosing therapy.

The ethanolic concentrate of Ponnankanni. was thought about for antimicrobial movement study in contrast to therapeutically significant gram-positive microbes, for example, Staphylococcus aureus, Bacillus subtilis, Bacillus polymexia and Streotococcus faecalis, gram negative microscopic organisms, for example, Pseudomonas aerugenosa, Salmonella typhii, Shigella dysenteriae and Escherichia coli and parasites like Penicillum notatum, Aspergillus niger and Candida albicans. The consequences of zone of restraint concentrate on uncovered focus dependant nature of the concentrate with better viability against gram-positive microbes than gram-negative microorganisms. The current review shows the possible value of Ponnankanni. ethereal parts in the treatment of different pathogenic infections as referenced in the ayurvedic writing.