Medical Science
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DOI: The Impact of High Immunological Sensitization on Donor Kidney Morphology in High-Risk Transplant Recipients
Makhmudov Qodirjon , DSc, Associate Professor, Department of Surgery and Transplantology, Faculty No. 2, Tashkent State Medical University, Tashkent, Uzbekistan Ravshanov Sultonali , Master’s degree, Surgery and Transplantology, Faculty No. 2, Tashkent State Medical University, Tashkent, Uzbekistan Irisov Ortiqali , DSc, Associate Professor, Surgery and Transplantology, Faculty No. 2, Tashkent State Medical University, Tashkent, UzbekistanAbstract
Kidney transplantation is widely recognized as the most effective treatment for patients with end-stage renal disease, providing improved survival and quality of life compared to long-term dialysis. Nevertheless, immunologically high-risk recipients remain vulnerable to adverse transplant outcomes due to preexisting sensitization and the presence of donor-specific antibodies. High sensitization is commonly associated with previous blood transfusions, pregnancies, or prior transplantations and is considered a major risk factor for antibody-mediated rejection. The present study aimed to investigate the impact of high sensitization on donor kidney morphology in immunologically high-risk patients undergoing kidney transplantation. Histopathological characteristics of donor kidneys were evaluated and correlated with the immunological status of recipients. Particular attention was given to glomerular, vascular, and tubulointerstitial alterations that may influence graft function and survival. The findings demonstrated that highly sensitized recipients were more likely to receive donor kidneys exhibiting significant morphological changes, including vascular thickening, interstitial fibrosis, tubular injury, and glomerular abnormalities. These structural alterations were associated with an increased incidence of delayed graft function and early post-transplant complications. Furthermore, a strong relationship was observed between elevated sensitization levels and the severity of histological abnormalities, suggesting that immunological factors may contribute to both pre-transplant and post-transplant graft injury. The study highlights the importance of comprehensive immunological assessment and detailed morphological evaluation of donor kidneys before transplantation. Understanding the interaction between recipient sensitization and donor kidney morphology may improve risk stratification, optimize donor-recipient matching, and contribute to the development of individualized therapeutic strategies aimed at enhancing graft survival and long-term transplant success in immunologically high-risk patient populations.
Keywords
Kidney transplantation, Sensitization, Donor-specific antibodies (DSA)
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Copyright (c) 2026 Makhmudov Qodirjon, Ravshanov Sultonali, Irisov Ortiqali
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