Medical Science
| Open Access |
DOI: The Influence of Controlled Hypotension on Cerebral Blood Flow During Neurosurgical Operations
Temur Malik Murotov , PhD, Associate Professor, Department of Anesthesiology and Resuscitation, Tashkent State Medical University, Tashkent, Uzbekistan Ozodbek Abdisattarov , Master's Student at the Department of Anesthesiology and Resuscitation, Tashkent State Medical University, Tashkent, UzbekistanAbstract
This article examines the effects of controlled hypotension on cerebral blood flow (CBF) during neurosurgical procedures. Controlled hypotension is a technique used to reduce intraoperative blood loss and improve surgical field visualization by lowering mean arterial pressure (MAP). While the method has long-standing applications in various surgeries, its impact on cerebral perfusion — especially in patients undergoing brain operations — remains complex and contested. This review integrates findings from clinical and experimental studies, demonstrating that although controlled hypotension can maintain cerebral perfusion pressure (CPP) within target ranges, it may not always improve CBF, particularly in patients with compromised autoregulatory mechanisms. Optimizing cerebral hemodynamics during neurosurgery requires careful balance to prevent hypoperfusion and secondary ischemic injury.
Keywords
Controlled hypotension, Neurosurgery, Cerebral blood flow (CBF)
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Copyright (c) 2026 Temur Malik Murotov, Ozodbek Abdisattarov
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