Medical Science
| Open Access |
DOI: A Scoping Review on Life-Threatening Diseases and Their Long-Term Side Effects Within Rehabilitation Settings
Rafsana Ferdouse , MPH (Masters of Public Health), Monroe University Md Omar Faruque , Master of Business Administration in Management Information Systems (MBA-MIS) At International American University, Los Angeles, USAAbstract
The scoping review examines long-term side effects in patients who recover from life-threatening diseases while undergoing rehabilitation using qualitative research coupled with articles obtained exclusively from Google Scholar. The improved survival rates of critical illnesses from medical progress now require society to analyze the prolonged health effects patients face within and outside rehabilitation programs. The review details repeated physical along with psychological and social and occupational hurdles which survivors experience including persistent fatigue along with pain and anxiety and depression and social distancing and employment readjustment issues. The study looks into current rehabilitation approaches and establishes how multidisciplinary care helps address persistent consequences. The research data demonstrates that healthcare treatment lacks compatibility with complete rehabilitation therapies which address the individual as a whole beyond the acute phase. The study demonstrates the necessity to create comprehensive rehabilitation programs which focus on the individual patient and provide both physical and psychosocial support. The research is limited by database constraints along with its qualitative nature and requires future investigation to use expanded research methods and study diseases specifically. This review expands the field of knowledge that seeks to enhance both rehabilitation outcomes and survivor quality of life for persons facing life-threatening illnesses.
Keywords
Life-threatening diseases, rehabilitation, long-term side effects, qualitative research, psychosocial recovery, patient-centered care
References
Almufarrij, I., Uus, K., & Munro, K. J. (2020). Does coronavirus affect the audio-vestibular system? A rapid systematic review. International journal of audiology, 59(7), 487-491.
Barskova, T., & Oesterreich, R. (2009). Post-traumatic growth in people living with a serious medical condition and its relations to physical and mental health: A systematic review. Disability and rehabilitation, 31(21), 1709-1733.
Clement, S. C., Peeters, R. P., Ronckers, C. M., Links, T. P., Van Den Heuvel-Eibrink, M. M., Van Dijkum, E. N., ... & Van Santen, H. M. (2015). Intermediate and long-term adverse effects of radioiodine therapy for differentiated thyroid carcinoma–a systematic review. Cancer treatment reviews, 41(10), 925-934.
Cornish, D., Holterhues, C., Van de Poll-Franse, L. V., Coebergh, J. W., & Nijsten, T. (2009). A systematic review of health-related quality of life in cutaneous melanoma. Annals of oncology, 20, vi51-vi58.
Coventry, P. A., Grande, G. E., Richards, D. A., & Todd, C. J. (2005). Prediction of appropriate timing of palliative care for older adults with non-malignant life-threatening disease: a systematic review. Age and ageing, 34(3), 218-227.
Crowe, M., Jordan, J., Burrell, B., Jones, V., Gillon, D., & Harris, S. (2016). Mindfulness-based stress reduction for long-term physical conditions: A systematic review. Australian & New Zealand Journal of Psychiatry, 50(1), 21-32.
Eisenberg, E., McNicol, E. D., & Carr, D. B. (2005). Efficacy and safety of opioid agonists in the treatment of neuropathic pain of nonmalignant origin: systematic review and meta-analysis of randomized controlled trials. Jama, 293(24), 3043-3052.
Flowers, H. L., Skoretz, S. A., Silver, F. L., Rochon, E., Fang, J., Flamand-Roze, C., & Martino, R. (2016). Poststroke aphasia frequency, recovery, and outcomes: a systematic review and meta-analysis. Archives of physical medicine and rehabilitation, 97(12), 2188-2201.
Fugazzaro, S., Contri, A., Esseroukh, O., Kaleci, S., Croci, S., Massari, M., ... & Costi, S. (2022). Rehabilitation interventions for post-acute COVID-19 syndrome: a systematic review. International journal of environmental research and public health, 19(9), 5185.
Gowing, L. R., HENRY‐EDWARDS, S. M., Irvine, R. J., & Ali, R. L. (2002). The health effects of ecstasy: a literature review. Drug and alcohol review, 21(1), 53-63.
Grünfeld, F. H., Raunkiaer, M., & Shabnam, J. (2025). Life-threatening diseases and long-term side effects in a rehabilitation context: a scoping review. Journal of Public Health, 1-18.
Guina, J., Rossetter, S. R., DeRhodes, B. J., Nahhas, R. W., & Welton, R. S. (2015). Benzodiazepines for PTSD: a systematic review and meta-analysis. Journal of Psychiatric Practice®, 21(4), 281-303.
Hong, C. H., Napeñas, J. J., Hodgson, B. D., Stokman, M. A., Mathers-Stauffer, V., Elting, L. S., ... & Dental Disease Section, Oral Care Study Group, Multi-national Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO). (2010). A systematic review of dental disease in patients undergoing cancer therapy. Supportive care in cancer, 18, 1007-1021.
Jack, K., McLean, S. M., Moffett, J. K., & Gardiner, E. (2010). Barriers to treatment adherence in physiotherapy outpatient clinics: a systematic review. Manual therapy, 15(3), 220-228.
Kerckhove, N., Collin, A., Condé, S., Chaleteix, C., Pezet, D., & Balayssac, D. (2017). Long-term effects, pathophysiological mechanisms, and risk factors of chemotherapy-induced peripheral neuropathies: a comprehensive literature review. Frontiers in pharmacology, 8, 86.
Kidd, T., Carey, N., Mold, F., Westwood, S., Miklaucich, M., Konstantara, E., ... & Cooke, D. (2017). A systematic review of the effectiveness of self-management interventions in people with multiple sclerosis at improving depression, anxiety and quality of life. PloS one, 12(10), e0185931.
Kim, G. M., Lim, J. Y., Kim, E. J., & Park, S. M. (2019). Resilience of patients with chronic diseases: A systematic review. Health & social care in the community, 27(4), 797-807.
Mehlhorn, J., Freytag, A., Schmidt, K., Brunkhorst, F. M., Graf, J., Troitzsch, U., ... & Gensichen, J. (2014). Rehabilitation interventions for postintensive care syndrome: a systematic review. Critical care medicine, 42(5), 1263-1271.
Olbrich, K. J., Müller, D., Schumacher, S., Beck, E., Meszaros, K., & Koerber, F. (2018). Systematic review of invasive meningococcal disease: sequelae and quality of life impact on patients and their caregivers. Infectious diseases and therapy, 7, 421-438.
Pinto, A., Faiz, O., Davis, R., Almoudaris, A., & Vincent, C. (2016). Surgical complications and their impact on patients’ psychosocial well-being: a systematic review and meta-analysis. BMJ open, 6(2), e007224.
Rafsten, L., Danielsson, A., & Sunnerhagen, K. S. (2018). Anxiety after stroke: A systematic review and meta-analysis. Journal of Rehabilitation Medicine (Stiftelsen Rehabiliteringsinformation), 50(9).
Roikjær, S. G., Gärtner, H. S., & Timm, H. (2022). Use of narrative methods in rehabilitation and palliative care in Scandinavian countries: A scoping review. Scandinavian Journal of Caring Sciences, 36(2), 346-381.
Salamanna, F., Veronesi, F., Martini, L., Landini, M. P., & Fini, M. (2021). Post-COVID-19 syndrome: the persistent symptoms at the post-viral stage of the disease. A systematic review of the current data. Frontiers in medicine, 8, 653516.
Van den Berg, M. E., Castellote, J. M., de Pedro-Cuesta, J., & Mahillo-Fernandez, I. (2010). Survival after spinal cord injury: a systematic review. Journal of neurotrauma, 27(8), 1517-1528.
Wang, W., Zhou, H., & Liu, L. (2018). Side effects of methotrexate therapy for rheumatoid arthritis: A systematic review. European journal of medicinal chemistry, 158, 502-516.
Woolf, C., Muscara, F., Anderson, V. A., & McCarthy, M. C. (2016). Early traumatic stress responses in parents following a serious illness in their child: A systematic review. Journal of Clinical Psychology in Medical Settings, 23, 53-66.
Zwakman, M., Jabbarian, L. J., van Delden, J. J., van der Heide, A., Korfage, I. J., Pollock, K., ... & Kars, M. C. (2018). Advance care planning: a systematic review about experiences of patients with a life-threatening or life-limiting illness. Palliative medicine, 32(8), 1305-1321.
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