Clinical And Laboratory Features Of Cardiorenal Syndrome On The Background Of Carbohydrate Exchange Disorders
Khudoyberganova Shoira Shavkatovna , Assistant Of The Department Of Propedeutics Of Internal Diseases, Tashkent Medical Academy, UzbekistanAbstract
Violation of the kidney filtration function is common enough among patients with cardiovascular disease (CVD), especially against disorders of carbohydrate metabolism (IGM). Renal dysfunction (PD) is associated with more frequent development of cardiovascular complications. In turn, the probability of development of renal disease in patients with cardiovascular disease is significantly higher than in general population. This bidirectional pathogenetic mechanisms existing between cardiovascular and kidney diseases were the basis for the formation of cardiorenal syndrome concept. The review discusses the general parts of pathogenesis within the cardiovascular continuum. In addition, it shows the effect on metabolic disorders during CVD combined with renal dysfunction. The review reveals a recent view on the main mechanisms of cardiorenal syndrome.
Keywords
Cardiorenal syndrome, systemic inflammation, endothelial dysfunction, insulin resistance
References
Barbarash O.L., Avramenko O.E., Osokina A.V., Sumin A.N., Veremeev A.V. The role of pro-inflammatory factors in assessing the prognosis of patients with progressive angina pectoris in combination with type 2 diabetes mellitus // Cardiology. - 2017. - No. 4. - P. 39-45.
Barbarash O.L., Kashtalap V.V., Karetnikova V.N., Vorontsova N.L., Devyatova V.A., Goncharenko M.V., Barbarash L.S. Clinical significance of indicators of endothelial dysfunction, oxidative stress and hemostasis in patients with myocardial infarction // Pathology of blood circulation and cardiac surgery. - 2015. - No. 2. - S. 28-33.
Karetnikova V.N., Evseeva M.V., Kalaeva V.V. Renal dysfunction in ST-segment elevation myocardial infarction: risk factors, impact on prognosis // Heart. - 2016. - T. 13, No. 6 (80). - S. 339-346.
Kobalova Zh.D., Villevalde S.V., Moiseev V.S. Cardiovascular diseases and functional state of the kidneys // Russian Journal of Cardiology. - 2018. - No. 4. - P. 33-47.
Ogarkov M.Yu., Barbarash O.L., Kazachek Ya.V., Kvitkova L.V., Polikutina O.M., Barbarash L.S. Prevalence of components of metabolic syndrome x in the indigenous and non-indigenous population of Mountain Shoria // Siberian Scientific Medical Journal. - 2014. - T. 24, No. 1. - S. 108-111.
Popov S.I., Nagibovich O.A., Shustov S.B. Structural and functional state of the heart and coronary blood flow in patients with type 2 diabetes mellitus with nephropathy // Nephrology. - 2019. - T. 15, No. 1. - S. 48-53.
Savelieva S.A., Kryachkova A.A., Kutyrina I.M., Shestakova M.V. Cardiorenal relationships in patients with type 2 diabetes mellitus and obesity // Clinical Nephrology. - 2019. - No. 5. - S. 36-40.
Shestakova M.V., Shamkhalova M.Sh., Yarek Martynova I.Ya. Diabetes mellitus and chronic kidney disease: achievements, unresolved problems and treatment prospects // Diabetes mellitus. - 2016. - No. 1. - P. 81-88
Ahmed A., Rich M.W., Sanders P.W. Perry G.J.,Bakris G.L.,Zile M.R.,Love T.E.,Aban I.B.,Shlipak M.G. Chronic kidney disease associated mortality in diastolic versus systolic heart failure: a propensity matched study // Am. J. Cardiol. – 2017. – № 99. – P. 393-398.
Alexandraki K., Piperi C., Kalofoutis C., Singh J., Alaveras A., Kalofoutis A. Inflammatory process in type 2 diabetes: the role of cytokines // Ann. NYAcad. Sci. –2016. – № 1084. – P. 89-117.
Amann K. Media calcification and intima calcification are distinct entities in chronic kidney disease // Clin. J. Am. Soc. Nephrol. – 2018. – Vol. 3, № 6. – P. 1599-1605.
Biondi-Zoccai G.L., Abbate A., Liuzzo G., Biasucci L.M. Atherothrombosis, inflammation, and diabetes // J. Am. Coll. Cardiol. – 2018. – № 41. – P 1071-1077.
Camici P. G., Crea F. Coronary microvascular dysfunction // Engl. J. Med. – 2019. – Vol. 356, № 8. – P. 830-840.
Choi J. Ch., Cha K. S., Ahn J. H.,Lee H.W., Oh J.H., Choi J.H., Lee H.C., Yun E., Hong T.J., Jang H.Y., Choi J.H., Jeong M.H., Ahn Y., Chae S. C., Kim Y. J. The Incidence and Clinical Predictors of Persistent Renal Dysfunction in Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention: Results from the Korea Working Group on Myocardial Infarction // Circulation. – 2014. – Vol. 126. – А17296.
Dandamudi S., Glockner J., Slusseretal J. Myocardial Fibrosis Identifiedby Cardiac MR Iandthe Associated Cardio-Renal Dysfunction // Circulation. – 2018. – Vol. 124. – A14397.
Article Statistics
Copyright License
Copyright (c) 2021 The American Journal of Medical Sciences and Pharmaceutical Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.