Articles
| Open Access |
DOI: Prenatal stress and neurodevelopmental disorders: neuroanatomical and psychiatric outcomes
Gayrat Polvonov , Researcher, Department of Anatomy and Histology, Urgench Branch of Tashkent Medical Academy, Khorezm, Uzbekistan Nazarova Malokhat , PhD, Department of Pediatrics and Higher Nursing, Urgench Branch of Tashkent Medical Academy, Khorezm, Uzbekistan Dilorom Adilbekovа , Professor, Department of Anatomy and Clinical Anatomy, Tashkent Medical Academy, Tashkent, UzbekistanAbstract
Prenatal stress has been increasingly recognized as a significant factor influencing fetal brain development, leading to long-term neuroanatomical and psychiatric consequences. This literature review synthesizes current research on the impact of maternal stress during pregnancy on offspring neurodevelopment, focusing on structural brain abnormalities and associated psychiatric disorders. Evidence suggests that prenatal stress disrupts neurogenesis, synaptic plasticity, and hypothalamic-pituitary-adrenal (HPA) axis function, increasing susceptibility to conditions such as autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), schizophrenia, and mood disorders. Understanding these mechanisms is crucial for developing early intervention strategies to mitigate adverse outcomes.
Keywords
Prenatal stress, neurodevelopmental disorders, fetal brain development
References
Arnsten, A. F. T. (2009). Stress signalling pathways that impair prefrontal cortex structure and function. Nature Reviews Neuroscience, 10(6), 410-422. https://doi.org/10.1038/nrn2648
Beversdorf, D. Q., Stevens, H. E., & Jones, K. L. (2018). Prenatal stress, maternal immune dysregulation, and their association with autism spectrum disorders. Current Psychiatry Reports, 20(9), 76. https://doi.org/10.1007/s11920-018-0945-4
Buss, C., Davis, E. P., Muftuler, L. T., Head, K., & Sandman, C. A. (2012). High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old children. Psychoneuroendocrinology, 35(1), 141-153. https://doi.org/10.1016/j.psyneuen.2009.07.010
Fatemi, S. H., & Folsom, T. D. (2009). The neurodevelopmental hypothesis of schizophrenia, revisited. Schizophrenia Bulletin, 35(3), 528-548. https://doi.org/10.1093/schbul/sbn187
Glover, V. (2011). Annual research review: Prenatal stress and the origins of psychopathology: An evolutionary perspective. Journal of Child Psychology and Psychiatry, 52(4), 356-367. https://doi.org/10.1111/j.1469-7610.2011.02371.x
Lupien, S. J., McEwen, B. S., Gunnar, M. R., & Heim, C. (2009). Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nature Reviews Neuroscience, 10(6), 434-445. https://doi.org/10.1038/nrn2639
Qiu, A., Rifkin-Graboi, A., Chen, H., Chong, Y. S., Kwek, K., Gluckman, P. D., Fortier, M. V., & Meaney, M. J. (2015). Maternal anxiety and infants' hippocampal development: Timing matters. Translational Psychiatry, 5(3), e552. https://doi.org/10.1038/tp.2015.44
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Copyright (c) 2025 Gayrat Polvonov, Nazarova Malokhat, Dilorom Adilbekovа
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