Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of the joints and surrounding tissues, which can lead to joint damage and disability. Understanding the prevalence and risk factors of RA, particularly in specific demographic groups, is crucial for developing effective public health strategies and interventions. This study aims to investigate the prevalence and risk factors of RA in the adult population of South Korea, with a particular focus on age and sex differences. Using a cross-sectional survey, we collected data from a nationally representative sample of 1,500 adults aged 20 years and older. Results indicated a higher prevalence of RA in women, with the peak incidence occurring in those aged 50–60 years. The study also identified significant risk factors for RA, including family history, smoking, and obesity. These findings underscore the need for age- and sex-specific interventions to prevent and manage RA, particularly in high-risk groups.

Rheumatoid arthritis, prevalence, age differences

Firestein, G.S. Evolving concepts of rheumatoid arthritis. Nature 2003, 423, 356–361. [Google Scholar] [CrossRef] [PubMed]

Alamanos, Y.; Drosos, A.A. Epidemiology of adult rheumatoid arthritis. Autoimmun. Rev. 2005, 4, 130–136. [Google Scholar] [CrossRef] [PubMed]

Gabriel, S.E.; Michaud, K. Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases. Arthritis Res. Ther. 2009, 11, 229. [Google Scholar] [CrossRef] [PubMed]

Cross, M.; Smith, E.; Hoy, D.; Carmona, L.; Wolfe, F.; Vos, T.; Williams, B.; Gabriel, S.; Lassere, M.; Johns, N.; et al. The global burden of rheumatoid arthritis: Estimates from the global burden of disease 2010 study. Ann. Rheum. Dis. 2014, 73, 1316–1322. [Google Scholar] [CrossRef]

Michaud, K.; Wolfe, F. Comorbidities in rheumatoid arthritis. Best Pract. Res. Clin. Rheumatol. 2007, 21, 885–906. [Google Scholar] [CrossRef]

Rasch, E.K.; Hirsch, R.; Paulose-Ram, R.; Hochberg, M.C. Prevalence of rheumatoid arthritis in persons 60 years of age and older in the United States: Effect of different methods of case classification. Arthritis Rheum. 2003, 48, 917–926. [Google Scholar] [CrossRef]

Akar, S.; Birlik, M.; Gurler, O.; Sari, I.; Onen, F.; Manisali, M.; Tirpan, K.; Demir, T.; Meral, M.; Akkoc, N. The prevalence of rheumatoid arthritis in an urban population of Izmir-Turkey. Clin. Exp. Rheumatol. 2004, 22, 416–420. [Google Scholar]

Symmons, D.; Turner, G.; Webb, R.; Asten, P.; Barrett, E.; Lunt, M.; Scott, D.; Silman, A. The prevalence of rheumatoid arthritis in the United Kingdom: New estimates for a new century. Rheumatology 2002, 41, 793–800. [Google Scholar] [CrossRef]

Cutolo, M.; Seriolo, B.; Villaggio, B.; Pizzorni, C.; Craviotto, C.; Sulli, A. Androgens and estrogens modulate the immune and inflammatory responses in rheumatoid arthritis. Ann. N. Y. Acad. Sci. 2002, 966, 131–142. [Google Scholar] [CrossRef]

Oliver, J.E.; Silman, A.J. Risk factors for the development of rheumatoid arthritis. Scand. J. Rheumatol. 2006, 35, 169–174. [Google Scholar] [CrossRef]

Ko, K.M.; Moon, S.J. Prevalence, incidence, and risk factors of malignancy in patients with rheumatoid arthritis: A nationwide cohort study from Korea. Korean J. Intern. Med. 2023, 38, 113–124. [Google Scholar] [CrossRef] [PubMed]

Safiri, S.; Kolahi, A.A.; Hoy, D.; Smith, E.; Bettampadi, D.; Mansournia, M.A.; Almasi-Hashiani, A.; Ashrafi-Asgarabad, A.; Moradi-Lakeh, M.; Qorbani, M.; et al. Global, regional and national burden of rheumatoid arthritis 1990–2017: A systematic analysis of the Global Burden of Disease study 2017. Ann. Rheum. Dis. 2019, 78, 1463–1471. [Google Scholar] [CrossRef] [PubMed]

Radu, A.F.; Bungau, S.G. Management of Rheumatoid Arthritis: An Overview. Cells 2021, 10, 2857. [Google Scholar] [CrossRef]

Schäfer, C.; Keyßer, G. Lifestyle Factors and Their Influence on Rheumatoid Arthritis: A Narrative Review. J. Clin. Med. 2022, 11, 7179. [Google Scholar] [CrossRef]

Klareskog, L.; Stolt, P.; Lundberg, K.; Källberg, H.; Bengtsson, C.; Grunewald, J.; Rönnelid, J.; Harris, H.E.; Ulfgren, A.K.; Rantapää-Dahlqvist, S.; et al. A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum. 2006, 54, 38–46. [Google Scholar] [CrossRef]

Lu, B.; Hiraki, L.T.; Sparks, J.A.; Malspeis, S.; Chen, C.Y.; Awosogba, J.A.; Arkema, E.V.; Costenbader, K.H.; Karlson, E.W. Being overweight or obese and risk of developing rheumatoid arthritis among women: A prospective cohort study. Ann. Rheum. Dis. 2014, 73, 1914–1922. [Google Scholar] [CrossRef]

Zamudio-Cuevas, Y.; Martínez-Flores, K.; Martínez-Nava, G.A.; Clavijo-Cornejo, D.; Fernández-Torres, J.; Sánchez-Sánchez, R. Rheumatoid Arthritis and Oxidative Stress. Cell. Mol. Biol. 2022, 68, 174–184. [Google Scholar] [CrossRef]

Collaborators, G.R.A. Global, regional, and national burden of rheumatoid arthritis, 1990–2020, and projections to 2050: A systematic analysis of the Global Burden of Disease Study 2021. Lancet Rheumatol. 2023, 5, e594–e610. [Google Scholar] [CrossRef]

Li, X.; Sundquist, J.; Sundquist, K. Socioeconomic and occupational risk factors for rheumatoid arthritis: A nationwide study based on hospitalizations in Sweden. J. Rheumatol. 2008, 35, 986–991. [Google Scholar]

Massardo, L.; Pons-Estel, B.A.; Wojdyla, D.; Cardiel, M.H.; Galarza-Maldonado, C.M.; Sacnun, M.P.; Soriano, E.R.; Laurindo, I.M.; Acevedo-Vásquez, E.M.; Caballero-Uribe, C.V.; et al. Early rheumatoid arthritis in Latin America: Low socioeconomic status related to high disease activity at baseline. Arthritis Care Res. 2012, 64, 1135–1143. [Google Scholar] [CrossRef]