IMPACT OF GUT MICROBIOTA ON THE GUT-BRAIN AXIS IN NEUROLOGICAL DISORDERS AND THE ROLE OF ENDOCRINE AND METABOLIC MARKERS
Diyora Pulatova , Medical School Year 6, Central Asian University, UzbekistanAbstract
This review highlights the critical importance of gut microbiota in modulating the gut-brain axis and its consequences for neurological disorders, including autism, Alzheimer's disease, and Parkinson's disease. New evidence is just beginning to suggest that gut microbiota may affect brain functioning through the intricate pathways of the immune, endocrine, and metabolic systems. This review discusses how alterations in gut microbiota composition may lead to aberrant endocrine responses and changes in metabolic markers contributing to neuroinflammation, neurodegeneration, and behavioural symptoms related to these diseases. This study will look at the potential targeting of the gut microbiome as a therapeutic strategy for neurological disorders through bidirectional interactions between the gut and the central nervous system. These findings have relevance toward understanding the gut-brain axis in the search for new biomarkers and development of personalised interventions in better promotion of neurological health.
Keywords
Gut microbiota, gut-brain axis, neurological disorders
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