THE ROLE OF HOMOCYSTEINE AS A BIOMARKER OF CYTOKINE STORM IN IMMUNOONCOLOGY AND THERAPY OF COVID-19
Yulii Honskyi , President in Honskyi Scientific INC, USAAbstract
Homocysteine is a sulfur-containing amino acid that can act as an important biomarker of inflammatory processes, including cytokine storm, observed in various pathological conditions such as cancer and COVID-19. In the conditions of the cytokine storm characteristic of severe forms of COVID-19 and progressive stages of cancer, elevated homocysteine levels can increase oxidative stress and inflammatory reactions, which, in turn, exacerbates tissue and organ damage. Studies show that homocysteine can play a significant role in the pathogenesis of these conditions, affecting the vascular and immune systems. Thus, monitoring of homocysteine levels is important for the diagnosis, prognosis and development of new therapeutic strategies in the field of immuno-oncology and treatment of COVID-19.
ZENODO DOI:- https://doi.org/10.5281/zenodo.14162335
Keywords
Homocysteine, cytokine storm, immuno-oncology, COVID-19
References
Petrov V. I. et al. Mechanisms of cytokine storm development in COVID-19 and new potential targets of pharmacotherapy //Pharmacy and Pharmacology. - 2020. – Vol. 8. – No. 6. – pp. 380-391.
From Pathogenic Infections to Inflammation and Disease - the Tumultuous Road of the 'Cytokine Storm'. [Electronic resource] Access mode: https/www.frontiersin.org/research-topics/15743/from-pathogenic-infections-to-inflammation-and-disease---the-tumultuous-road-of-the-cytokine- storm (accessed 08/21/2024).
Abduganieva E. A. The role of homocysteine as a pathogenetic factor in the development of thrombophilic conditions //Siberian Medical Review. – 2023. – №. 2 (140). – Pp. 8-16.
McCaddon A., Miller J. W. Homocysteine—a retrospective and prospective appraisal //Frontiers in Nutrition. – 2023. – Vol. 10.
Baykulov A. K., Yusufov R. F., Ruziev K. A. Dependence of endothelial dysfunction with homocysteine content in the blood in experimental hypercholesterolemia //education science and innovative ideas in the world. – 2023. – vol. 17. – No. 1. – pp. 101-107.
Carpenè G. et al. Homocysteine in coronavirus disease (COVID-19): a systematic literature review //Diagnosis. – 2022. – Vol. 9. – No. 3. – pp. 306-310.
Zeimakh I. Ya. et al. The effect of correction of homocysteinemia on the clinical outcomes of lung damage associated with COVID-19 coronavirus infection //Bulletin of physiology and pathology of respiration. – 2023. – №. 87. – pp. 8-17.
Article Statistics
Copyright License
Copyright (c) 2024 Yulii Honskyi
This work is licensed under a Creative Commons Attribution 4.0 International License.