Articles
| Open Access |
DOI: CORRELATION BETWEEN ABDOMINAL ULTRASOUND FINDINGS AND PLATELET COUNT IN DENGUE FEVER PATIENTS: IMPLICATIONS FOR EARLY DIAGNOSIS AND MANAGEMENT
Laiba Razaq , Akhtar Saeed Trust Hospital, Pakistan Abdullah Khan , Akhtar Saeed Medical and Dental College, Pakistan Muhammad Nouman Tariq , Akhtar Saeed Medical and Dental College, Pakistan Syed Shayan Gilani , Akhtar Saeed Medical and Dental College, Pakistan Saima Khan , Akhtar Saeed Trust Hospital, Pakistan Muhammad Raza , Akhtar Saeed Medical and Dental College, Pakistan Muhammad Faizan Ali , Akhtar Saeed Medical and Dental College, Pakistan Tehreem Asghar , Akhtar Saeed Medical and Dental College, Pakistan Syed Muhammad Ali Akbar , Akhtar Saeed Medical and Dental College, Pakistan Seneen Noor , The International Center of Medical Sciences Research (ICMSR), 5900 Balconies Drive#12581, Austin TX, 78731 USA, The International Center of Medical Sciences Research (ICMSR), Islamabad Pakistan Elyeen Noor , The International Center of Medical Sciences Research (ICMSR), Islamabad Pakistan, The International Center of Medical Sciences Research (ICMSR), Office 5479 321-323 High Road Chadwell Heath Essex United Kingdom Rm6 6ax, USAAbstract
Objectives
This study aimed to investigate abdominal ultrasound changes in patients diagnosed with dengue fever and their relationship with platelet count.
Methods
A prospective observational study was conducted at a tertiary care medical college's radiology department in an urban area. One hundred cases diagnosed with dengue fever based on serology were included, following predefined inclusion and exclusion criteria.
Results
Among the 100 cases, 60 were male (60%) and 40 were female (40%). Seventy-six patients showed increased gallbladder wall thickness (GBWT) due to pericholecystic edema, 31 exhibited ascites, and 32 had splenomegaly. Thrombocytopenia was associated with increased third spacing and splenomegaly observed on abdominal ultrasound.
Practical Implications
This study emphasizes the importance of recognizing abdominal ultrasound features in suspected dengue cases while awaiting laboratory results. It provides crucial insights for medical professionals (undergraduates, postgraduates, and consultants) and patients, facilitating early intervention and potentially averting complications.
Conclusion
Gallbladder wall edema, splenomegaly, and ascites are prevalent in severe dengue cases. Detecting these features early may signal the likelihood of progression to severe dengue.
Keywords
Dengue, Dengue shock syndrome, Dengue Hemorrhagic
References
Guzman MG, Gubler DJ, Izquierdo A, Martinez E, Halstead SB. Dengue infection. Nat Rev Dis Primers. 2016 Jul 21;2:16055. doi: 10.1038/nrdp.2016.55
World Health Organization. Dengue and severe dengue. Available at: https://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue. Accessed January 2022.
Moras E, Achappa B, Murlimanju BV, Raj GN, Holla R, Madi D, D’Souza NV, Mahalingam S. Early diagnostic markers in predicting the severity of dengue disease. 3 Biotech. 2022 Oct;12(10):268. doi: 10.1007/s13205-022-03365-3.
Nguyen TT, Le NT, Nguyen NM, Do VC, Trinh TH, Vo LT. Clinical features and management of children with dengue-associated obstructive shock syndrome: A case report. Medicine (Baltimore). 2022 Oct 28;101(43):e31322. doi: 10.1097/MD.0000000000031322. PMID: 36316901; PMCID: PMC9622697.
Manzoor N, Farooq SM, tul Sughra SK, Siddiqi MI, Arooj S, Ishfaq A, Gilani SA, ul Abidin SZ. Role of ultrasonography in the diagnosis of dengue fever: Ultrasonography in The Diagnosis of Dengue Fever. Pakistan BioMedical Journal. 2022 Jan 31:375-9.
Santhosh VR, Patil PG, Srinath MG, Kumar A, Jain A, Archana M. Sonography in the diagnosis and assessment of dengue Fever. J Clin Imaging Sci. 2014 Mar 21;4:14. doi: 10.4103/2156-7514.129260. PMID: 24744971; PMCID: PMC3988603.
Thomas L, et al. Dengue Vascular Leakage Is Augmented by Mast Cell Degranulation Mediated by Immunoglobulin Fcγ Receptors. eLife. 2016;5:e05291. doi: 10.7554/eLife.05291.
Ibrahim MA, Hamzah SS, Md Noor J, et al. The association of ultrasound assessment of gallbladder wall thickness with dengue fever severity. Ultrasound J. 2022;14:13. doi: 10.1186/s13089-022-00262-w.
Leite LA, Macedo FC. Abdominal ultrasound findings in patients with dengue fever. J Diagn Med Sonogr. 2019;35(4):291-296.
Dewan N, Zuluaga D, Osorio L, Krienke ME, Bakker C, Kirsch J. Ultrasound in Dengue: A Scoping Review. Am J Trop Med Hyg. 2021 Jan 18;104(3):826-835. doi: 10.4269/ajtmh.20-0103. PMID: 33534759; PMCID: PMC7941833.
Moro L, et al. Comparison between chest X-ray and ultrasound diagnosis of pulmonary complications in patients with severe dengue. Rev Soc Bras Med Trop. 2017;50(3):353-356.
Nainggolan L, Wiguna C, Hasan I, Dewiasty E. Gallbladder Wall Thickening for Early Detection of Plasma Leakage in Dengue Infected Adult Patients. Acta Med Indones. 2018 Jul;50(3):193-199. PMID: 30333268
Martínez-Sellés M, et al. Cardiac findings in patients with dengue fever epidemic. Rev Esp Cardiol (Engl Ed). 2015;68(11):991-992.
Nahar K, Akhter S, Barua S, Begum D, Hasan MK. Ultrasonographic assessment of dengue fever and its correlation with platelet count: Correlating USG and platelet count in dengue fever. Bangladesh Med Res Counc Bull. 2021;47(1):23-8.
Azhar A, Saeed U, Piracha ZZ, Amjad A, Ahmed A, Batool SI, et al. SARS-CoV-2 related HIV, HBV, RSV, VZV, Enteric viruses, Influenza, DENV, S. aureus and TB co-infections. Arch Pathol Clin Res. 2021;5(1):026-033.
Piracha ZZ, Saeed U, Ahmed RAI, Khan FNA, Nasir MI. Global emergence of Langya virus: A serious public health concern. J Global Health. 2023;13.
Piracha ZZ, Saeed U, Tariq MN, Gilani SS, Rauf M, Ghyas H, et al. Emerging One Health Preparedness to Combat National Burden of Diseases in Pakistan: A Comprehensive Insight. J Community Med Health Solutions. 2023;4(2):080-088.
Piracha ZZ, Tariq MN, Rasool M, Gilani SS, Saeed U, Rana MSF, Arif M, et al. Catalyzing Global Action: Addressing SARS-CoV-2 Vaccine Hesitancy, Knowledge Disparities, and Epidemic Preparedness Challenges in Pakistan. Biomed J Sci & Tech Res. 2022;52(3):43702-43707.
Uppal SR, Uppal R, Khan AA, Saeed U, Piracha ZZ, Ali Z. Estimating the Prevalence of Fungal Nail Infections and Potential Concerns for Central Disease Surveillance Hub in Pakistan. Arch Clin Biomed Res. 2022;6(3):462-465.
Uppal SR, Khan AA, Uppal R, Saeed U, Piracha ZZ, Uppal R. Rising Surge of Antimicrobial Resistance and Urinary Tract Infections in Pakistani Children: A Potential Life-Threatening Scenario. Fortune J Health Sci. 2022;5(2):281-283.
Araújo FMM, et al. Sonographic findings in patients with dengue fever. J Ultrasound Med. 2019;38(2):491-497.
Parmar JP, Mohan C, Vora M. Patterns of Gall Bladder Wall Thickening in Dengue Fever: A Mirror of the Severity of Disease. Ultrasound Int Open. 2017 Apr;3(2):E76-E81. doi: 10.1055/s-0043-105262. Epub 2017 Jun 7. PMID: 28603785; PMCID: PMC5464115.
Tandon R, Yadav D. Ultrasonographic findings in dengue hemorrhagic fever: a retrospective analysis. J Clin Diagn Res. 2016;10(6):TC10–TC13. doi: 10.7860/JCDR/2016/18114.7990.
Guzmán MG, Harris E. Dengue. Lancet. 2015;385(9966):453-465. doi: 10.1016/S0140-6736(15)00126-8.
Huy NT, et al. Factors associated with dengue shock syndrome: a systematic review and meta-analysis. PLoS Negl Trop Dis. 2015;9(6):e0003972. doi: 10.1371/journal.pntd.0003972.
Tan J, Liu J, Zhang Q. The relationship between platelet count and ultrasonographic findings in patients with dengue fever: A retrospective analysis. Medicine (Baltimore). 2018;97(51):e13727. doi: 10.1097/MD.0000000000013727.
Kalayanarooj S, et al. Platelet-associated dengue illness (PADI): a novel risk factor for dengue hemorrhagic fever. Pathog Glob Health. 2017;111(7):332-341. doi: 10.1080/20477724.2017.1392423.
Lye DC, et al. The first dengue epidemic in Singapore: a cost analysis. Trans R Soc Trop Med Hyg. 2014;108(5):305-312. doi: 10.1093/trstmh/tru059.
Thomas L, et al. Evaluation of a commercial dengue NS1 antigen-capture ELISA for laboratory diagnosis of acute dengue virus infection. J Virol Methods. 2009;15(2):151-154. doi: 10.1016/j.jviromet.2009.03.024
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Copyright (c) 2024 Laiba Razaq , Abdullah Khan , Muhammad Nouman Tariq , Syed Shayan Gilani , Saima Khan , Muhammad Raza , Muhammad Faizan Ali , Tehreem Asghar , Syed Muhammad Ali Akbar , Seneen Noor , Elyeen Noor
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