Inflammatory periodontal diseases are one of the most common dental diseases in the world, along with dental caries. In the modern concept of the development of inflammatory periodontal diseases, one of the important roles is assigned to the body's immune response to the action of periodontal pathogenic microorganisms. In modern scientific literature, the concept of cytokine development of inflammatory periodontal diseases has been formed and substantiated. Evaluation of the cytokine profile of oral and gingival fluids allows us to determine the activity and severity of the disease. Well-founded immunological and molecular genetic mechanisms for the development of inflammatory periodontal diseases, associated with the influence of cytokines, make it possible to adjust the complex treatment of inflammatory periodontal diseases, determine the direction of personalized therapy for patients, determine the effectiveness of the treatment and the prognosis of the disease.

Inflammatory periodontal diseases, gingivitis, periodontitis

Avagimov , A.G. Functional activity of neutrophil leukocytes in inflammatory periodontal diseases / A.G. Avagimov , M.A. Bondarenko, I.A. Slavinsky // Kuban Scientific Medical Bulletin. – 2008. – No. 3-4.

Allais , G. Biofilm of the oral cavity / G. Allais // New in dentistry. – 2006. –No. 4 (136). – P. 4–14.

Bazarny, V.V. Immunological analysis of oral fluid as a potential diagnostic tool / V.V. Bazarny, L.G. Polushina, E.V. Vanevskaya // Russian Immunological Journal. – 2014. – T. 8, No. 3. – P. 769–771. DOI: 10.22138/2500-0918-2018-15-4-563-569.

Bolshedvorskaya , N.E. Etiopathogenetic features of inflammatory periodontal diseases / N.E. Bolshedvorskaya , E.M. Kazankova // Human health safety. – 2017. – No. 3. – P. 26–35. DOI: 10.17117/ na . 2016.04.03.294.

Borzikova , N.S. Markers of inflammatory processes in periodontal diseases / N.S. Borzikova // MS. – 2015. – No. 2. DOI: 10.21518 / 2079-701X-2015-2-78-79.

Bykova, N.I. Indicators of cellular and humoral immunity in experimental inflammation of periodontal tissues / N.I. Bykova, A.V. Odolsky , V.A. Grigoryan // Kuban Scientific Medical Bulletin. – 2016. – No. 6.

Van Der Byl, P. Relationship between periodontal diseases and the cardiovascular system / P. Van Der Byl // Problems of dentistry. – 2014. – No. 6.

Vasilyeva, N.A. Analysis of cytograms in patients with inflammatory periodontal diseases / N.A. Vasilyeva, A.I. Bulgakova, E.A. Imelbaeva // Kazan medical journal. – 2011. –T. 92, No. 1. – P. 41–45. DOI: 10.18481/2077-7566-2018-14-3-11-16.

The influence of immunomodulatory therapy on the cellular composition of gingival fluid in elderly people suffering from periodontitis / S.V. Krainov, V.F. Mikhalchenko, A.N. Popova, A.T. Yakovlev, I.V. Lynchenko // Problems of dentistry. – 2018. – No. 1.

Grudyanov , A.I. Periodontal diseases / A.I. Grudyanov . – Moscow: Medical Information Agency, 2009. – 336 p.

Dunyazina , T.M. Microorganisms of dental plaque / T.M. Dunyazina // Diseases of the endodont , periodontium and oral mucosa / ed. prof. A.K. Jordanishvili . – Moscow: Medpress-inform , 2008. – 183 p.

Zhelnin, E.V. The role of IL -1β and TNFRSF 11 b gene polymorphisms in the development of chronic periodontitis / E.V. Zhelnin // Current problems daily medicine : newsletter Ukrainian medical dental academies . – 2015. – No. 2 (50).

Zemskaya, E.A. Clinical and immunological parameters in patients after complex treatment of periodontitis / E.A. Zemskaya, V.V. Khazanova, T.V. Nikitina // Dentistry. – 1980. – No. 3. – P. 20–21.

The importance of some interleukins in the pathogenesis of periodontitis / V.V. Bazarny [and others] // Bulletin of the Ural Medical Academic Science. – 2017. – T. 14, No. 1. – P. 35–39.

Changes in the balance of cytokines in the gingival fluid in periodontal diseases and its significance for predicting regenerative disorders in periodontal tissues / L.Yu. Ostrovskaya, N.B. Zakharova, A.P. Mogila, L.S. Katkhanova , E.V. Akulova, E.B. Popykhova // Saratov Medical Scientific Journal. – 2014. – No. 10 (3). – pp. 435–440.

Immune and oxidative disorders in the pathogenesis of inflammatory periodontal diseases / A.L. Loktionov [and others] // Immunology. – 2015. – T. 36, No. 5. – P. 24–26.

Ippolitov, E.V. Features of the morphology of periodontal biofilm in inflammatory gum diseases (chronic catarrhal gingivitis, chronic periodontitis, Candida-associated periodontitis) according to electron microscopy / E.V. Ippolitov, L.V. Didenko, V.N. Tsarev // Clinical laboratory diagnostics. – 2015. – No. 12. – P. 59–63.

Isamulaeva , A. Z. Analysis of the association of variant alleles of the IL-1b gene (511 c / t) on the pathogenesis of periodontal diseases in patients with gastric and duodenal ulcers / A. Z. Isamulaeva // Modern problems of science and education. – 2015. – No. 6.

The use of molecular markers in the examination of patients with periodontal pathology / L.Yu. Ostrovskaya, A.P. Mogila, A.I. Khanina, D. Beibulatov , L.S. Katkhanova , A.V. Rezanov // Bulletin of SSTU. – 2013. – No. 1 (70).

Clinical variants of chronic generalized periodontitis, genetic polymorphism and systemic production of inflammatory cytokines / E.Sh. Grigorovich, E. Pomorgailo , E.Yu. Khosutova , S. S. Sterpanov // Dentistry. – 2015. – No. 5. – P. 11–17.

Kovalevsky, A.M. Etiology and pathogenesis of inflammatory periodontal diseases (literature review). Part I / A.M. Kovalevsky, V.A. Kovalevsky // Institute of Dentistry. – 2017. – No. 4 (77). – pp. 88–90.

Kostrigina , E.D. Modern view on the etiopathogenesis of periodontitis (literature review) / E.D. Kostrigina , L.A. Zyulkina , P.V. Ivanov // News of universities. Region. Medical Sciences. – 2017. – No. 3 (43). DOI 10.21685/2072-3032-2017-3-1.

Kuznetsova, O.A. Cytokines as an indicator of the local immune status of patients with chronic periodontitis / O.A. Kuznetsova, E.I. Gubanova, V.I. Shemonaev // Medicinal Bulletin. – 2013. – T. 7, No. 2 (50). – pp. 20–26.

Kravchenko, E.V. Roncoleukin in the complex treatment of periodontal diseases / E.V. Kravchenko, D.S. Kravchenko // Fundamental research. – 2012. – No. 7-2. – pp. 355–358.

Melekhov, S.V. State of local immunity and microbiocenosis of the oral cavity in patients with chronic generalized periodontitis / S.V. Melekhov, N.V. Kolesnikova, E.S. Ovcharenko // Periodontology. – 2013. – No. 18 (1). – P. 3–9.

Miklyaev, S.V. Analysis of the prevalence of chronic inflammatory diseases of periodontal tissues / S.V. Miklyaev, O.M. Leonova, A.V. Sushchenko // Modern problems of science and education. – 2018. – No. 2. URL: http://science-education.ru / ru / article / view?id =27454

Moiseeva, E.G. Analysis of the effect of interleukin-4 on the functional properties of neutrophils in modeling periodontitis / E.G. Moiseeva // Bulletin of health and education in the XXI century. – 2006. – No. 11.

Assessment of the level of pro-inflammatory cytokines in patients with chronic periodontitis depending on bone mineral density before dental implantation / T.N. Shaimardanov, L.P. Gerasimova, T.S. Chemikosova , F.Kh. Kamilov // Modern problems of science and education. – 2017. – No. 1.

Oshnokov , A.K. Diagnostic and prognostic value of determining cytokines in gingival fluid in chronic periodontitis / A.K. Oshnokov , E.A. Bragin, L.Yu. Barycheva // Medical Bulletin of the North Caucasus. – 2016. – No. 4.

Parakhonsky , A.P. The role of cytokines in the pathogenesis of periodontitis / A.P. Parakhonsky , N.Yu. Perova // Natural and humanitarian studies. – 2015. – No. 7. – P. 75–81.

Petrova, N.Yu. Clinical and immunological effectiveness of muramyl dipeptide in the complex treatment of patients with chronic generalized periodontitis: abstract . dis . ...cand. honey. Sciences / Petrova N.Yu. – Rostov -on-Don, 2005. – 30 p.

Rizaev Zh.A. Prevalence of periodontal diseases among the urban population of Uzbekistan 2008 Med. magazine Uzbekistan No. 3 P. 6-8

Rizaev Zh.A, Nazarova N.Sh. The state of local immunity of the oral cavity in chronic generalized periodontitis . Bulletin of Science and Education 2020 ; 14-4 (92) pp. 35-40

Rizaev D.A., Rizaev E.A. Olimzhanov K.Zh. Integral assessment of the population risk of generalized periodontal disease. Russian dental journal. Vol. 24 No. 5, 2020 pp. 312-317 .

Properties of gingival fluid in acute gingivitis and chronic periodontitis / N.N. Tsybikov, E.T. Domanova, V.V. Zobnin, M.Yu. Ignatov, E.Yu. Oil, N.V. Isakova // Russian Dental Journal. – 2012. – No. 1.

Modern aspects of the etiology and pathogenesis of periodontal diseases / E.I. Fuks, Yu.A. Kareva, O.A. Galizina , E.S. Tabolina // Ross. med.-biol. Vestn . them. acad. I.P. Pavlova. – 2013. – No. 3.

The ratio of pathogenic representatives of the microbiocenosis of periodontal pockets in periodontitis of varying severity / O.A. Zorina, A.A. Kulakov, O.A. Boriskina, D.V. Rebrikov // ActaNaturae (Russian version). – 2011. – No. 2.

Suetenkov, D.E. Qualitative and quantitative assessment of periodontopathogenic microflora of the oral cavity using the Bana test / D.E. Suetenkov, A.V. Akulovich , E.A. Gritsenko // Periodontology. – 2012. – No. 2 (63). – pp. 66–70.

Level of cytokines in oral secretions in children with bronchial asthma / M.A. Abajidi , E.F. Lukushkina , I.V. Mayanskaya [et al.] // Cytokines and inflammation. – 2002. – T. 1, No. 3. – P. 9–14.

Usova, N.F. Inflammatory periodontal diseases: pathogenesis, principles of complex treatment / N.F. Usova // Siberian Medical Journal. – 2013. – No. 1. – P. 141–144.

Khaidarov A.M., Rizaev E.A. Prevalence of periodontal diseases among children and adults living in cities with different environmental conditions B iomedicine-2016 No. 1 P. 31-35.

Khokhlova, E.A. Adaptive immunity disorders in chronic inflammatory periodontal diseases: modern approaches to assessment and subsequent correction: abstract . dis ... cand. honey. Sciences: 01/14/14 / Khokhlova E.A. – Moscow, 2012. – 25 p.

Cytomorphometric assessment of the condition of periodontal tissues in the treatment of patients with chronic catarrhal gingivitis / V.V. Miroshnichesko [and others] // Problems of dentistry. – 2018. – T. 14, No. 2. – P. 42–47.

Shostenko , A.A. Features of microbiocenosis of gingival tissues and local immunity in patients with chronic and aggravated course of generalized catarrhal gingivitis / A.A. Shostenko // Medical perspectives. – 2014. – T. 19, No. 4. – P. 141–145.

A rray analysis for t-cell associated cytokines in gingival crevicular fluid; identifying altered profiles associated with periodontal disease status / B. Koshy, S. Reesj , D. Farnelld , Q. Weix, J. Waddington // J Periodontal Res. – 2014. – Vol. 49(2). – P. 237–245. Doi: 10.1016/j. jdent . 2019.04.009.

Assessment of IL-6, IL-8 and TNF- α levels in the gingival tissue of patients with periodontitis / K. Noh [et al.] // Experimental and therapeutic medicine. – 2013. – No. 6. – P. 847–851.

Microbiological and immunological studies of adult periodontitis in patients with noninsulin-dependent diabetes mellitus / J. J. Zambon, H. Reynolds, J. G. Fisher [et al.] // J. Periodontol . – 1988. – Vol. 59, No. 1. – P. 23–31.

Pintucci , JP Biofilms and infections of the upper respiratory tract / JP Pintucci , S. Corno, M. Garotta // Eur Rev Med Pharmacol Sci. – 2010. – Vol. 14. – P. 683–690.

Rossomando, E. Tumor necrosis factor alpha in gingival crevicular fluid as a possible indicator of periodontal disease in humans / E. Rossomando, J. Kennedy, J. Hadjimichael // Arch. Oral Biol. – 1990. – Vol. 35, No. 6. – P. 431–434.

Suchett -Kaye, G. Clinical usefulness of microbiological diagnostic tools in the management of periodontal disease / G. Suchett -Kaye, JJ Morrier , O. Barsotti // Res. Microbiol . – 2001. – Vol. 152, No. 7. – P. 631–639.