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DOI: EXPLORING THE APOPTOTIC EFFECTS OF ETHANOLIC EXTRACTS FROM HEXALOBUS MONOPETALUS LEAVES ON CERVICAL CANCER IN WISTAR RATS
Bertin Sezan , Laboratory of Biomembranes and Signalling Cell, University of Abomey-Calavi, Benin Tiburce Alphonse , Laboratory of Biomembranes and Signalling Cell, University of Abomey-Calavi, BeninAbstract
This study investigates the apoptotic effects of ethanolic extracts derived from Hexalobus Monopetalus leaves on cervical cancer in Wistar rats. Cervical cancer remains a significant health concern globally, necessitating the exploration of novel therapeutic agents. Hexalobus Monopetalus, a plant from the Annonaceae family, has exhibited promising pharmacological properties. The ethanolic extracts from its leaves are evaluated for their potential apoptotic effects on cervical cancer cells in an animal model. Through histopathological examination, biochemical assays, and molecular analyses, the study elucidates the apoptotic mechanisms underlying the anticancer activity of Hexalobus Monopetalus extracts, offering insights into their therapeutic potential for cervical cancer treatment.
Keywords
Hexalobus Monopetalus, Annonaceae, Ethanolic extracts
References
A.RICH Engl. & Diels ; eflore, la flore électronique de Tela botanica ; 1901 APD v.3.4.0 ;
A.RICH Benth., 2002-2016 in Engl.Monogr.Afr.Pfl.vi.56., plantes et botaniques, Annonaceae; le genre Hexalobus
AKOUEGNINOU A.,VANDER BURG W.J et VANDER MAESEN L.J.G.,2006; Flore analytique du Bénin. Brackuy-spublishers wagneningen, 1034p
AFFO B., 2015 Impact des extraits éthanoliques des feuilles de Hexalobus monopetalus sur le metabolism glucidique et lipidique des rats wistar, p43-p49
AUDRAN J-C, E. BOUREAU, « CYCADOPHYTES » Encyclopaediae universalis consulté le 8avril 2016
BOTHA C.J., NAUDE T.W., SWAN G.E et al., 1991, Suspected cycad (cycas revoluta) intoxication in dogs, J.S. Afr V et Assoc
BOYD M.R., 1989. Status of the NCI preclinical antitumor drug discovery scree. Principles & practices of oncology 3, 2-12
BRADY L.W., MICAILY B., MIYAMOTO C.T., KEIT J.I., MIESZKALSKI G.B., 1993. Therapeutic advances in radiologic treatment of cancer. Cancer 72,3463-3469
Brochure les cancers du col de l’utérus ; collection comprendre et agir
CLAUSE B.T. (1998), The wistar Institute Archives: Rats and History-Amphilsoc,Mendel Newsletter, fevrier 1998
Dr MULLER-ESNEAULT, DVM. ‘cycas revoluta’ : The sago palm,or cycas Toxicity 2009
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