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DOI: PLGF/ SFLT-1 Concentrations As Early Predictors Preeclampsia In Pregnancy During Pandemic Covid-19
Makhmudova Sevara Erkinovna , Samarkand State Medical Institute, Uzbekistan Negmadjanov Baxodur Boltaevich , Samarkand State Medical Institute, UzbekistanAbstract
The imbalance in placenta- originated angiogenic factors has been found to play an important role in
the pathogenesis of preeclampsia in recent years. Soluble fms- like tyrosine kinase 1 (sFlt-1) and
placental growth factor (PIGF) are the most studied proteins. sFlt-1, a splice variant of the vascular
endothelial growth factor (VEGF) receptor Flt-1, is a circulating antiangiogenic protein that inhibits
proangiogenic factors—VEGF and PIGF signalling in the vasculature. High levels of circulating sFlt-1 and
low levels of PIGF were observed in women with established preeclampsia and even before the onset
of clinical symptoms [1,6,9,11]
Keywords
PlGF/ SFLT-1 concentrations, placenta
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