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DOI: Pharmacological Activity Of The Possessing New Atypical Neuroleptics 1-Phenyltetrahydroisoquinoline Structure
Zafar Isomiddinovich Sanoev , Candidate Of Medical Sciences, Senior Scientific Researcher Of Department Of Pharmacology And Toxicology Of Institute Of Chemistry Of Plant Substances, Academy Of Sciences Of Republic Of Uzbekistan,Tashkent, Uzbekistan Yuriy Rahmanovich Mirzaev , Candidate Of Medical Sciences, Senior Scientific Researcher Of Department Of Pharmacology And Toxicology Of Institute Of Chemistry Of Plant Substances, Academy Of Sciences Of Republic Of Uzbekistan,Tashkent, UzbekistanAbstract
The first synthesized derivative of (3¢,4¢-methylenedioxyphenyl) -6,7-methylenedioxy-1,2,3,4-
tetrahydroquinoline, conventionally designated F-29, showed neuroleptic properties - they have
hypothermic, cataleptogenic, less pronounced suppression of motor activity, lack of central αadreno- and M-anticholinergic action and less toxic in severity comparable to the activity of a more
close analogue of the neuroleptic haloperidol, which has motor and autonomic disorders [1], which F29 lacks
Keywords
Neuroleptic activity,, catalepsy,
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