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DOI: Endocrine Structures Of The Lungs In Ontogenesis And In Children With Pneumonia
Blinova Sofya Anatolyevna , Doctor Of Medical Sciences, Professor Of The Department Of Histology, Cytology And Embryology Of Samarkand State Medical Institute, Uzbekistan Khamidov Farida Muinova , Head Of The Department Of Pathological Anatomy Of Samarkand State Medical Institute, Candidate Of Medical Sciences, Associate Professor, Uzbekistan Urakov Kuvandik Nematovich , Assistant Department Of Pathological Anatomy Samarkand State Medical Institute, UzbekistanAbstract
During embryonic histogenesis of human lungs, early morpho- functional differentiation of apudocytes is observed. In the lungs of young children with an inflammatory pathology of this organ, endocrine structures are detected with great constancy, and their number is large. The longer the disease lasts, the more apudocytes and NETs are found in the bronchi and respiratory tract. In large bronchi there are more endocrine structures than in small ones. Inflammatory lung diseases in early postnatal ontogenesis are a predisposing factor for apudocyte hyperplasia.
Keywords
Apudocytes,, , respiratory system
References
Young LR, Brody AS, Inge TH, Acton JD, Bokulic RE, Langston C, Deutsch GH.Neuroendocrine cell distribution and frequency distinguish neuroendocrine cell hyperplasia of infancy from other pulmonary disorders. Chest. 2011 May; 139 (5): 1060-71.
Koo CW, Baliff JP, Torigian DA, Litzky LA, Gefter WB, Akers SR Spectrum of pulmonary neuroendocrine cell proliferation: diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, tumorlet, and carcinoids. Am J Roentgenol. 2010 Sep; 195 (3): 661-8.
Linnoila RI. Functional facets of the pulmonary neuroendocrine system Laboratory Investigation (2006) 86, 425–4440
Rizvi SM, Goodwill J, Lim E, Yap YK, Wells AU, Hansell DM, Davis P, Selim AG, Goldstraw P, Nicholson AG. The frequency of neuroendocrine cell hyperplasia in patients with pulmonary neuroendocrine tumors and non- neuroendocrine cell carcinomas. Histopathology.2009 Sep; 55(3): 332-7.
DaviesSJ, Gosney R, HansellDM , WellsAU, du BoisRM, BurkeMM, MN Sheppard, and NicholsonAG. Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under–recognized spectrum of disease. Thorax. Mar 2007; 62 (3): 248-252.
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