Articles
| Open Access | The Importance Of Lyophilization Of Microorganisms And Biologicals
Okiev S.S. , Applicant (PhD) State Scientific Center For Quality Control And Circulation Of Veterinary Medicines And Feed Additives, UzbekistanAbstract
This article provides arguments about the need for scientific research aimed at maintaining the stability of biological properties during long-term storage, production, reference, epizootic strains of microorganisms through the development and optimization of lyophilization parameters.
Keywords
Protective environment, storage methods,, collection strain
References
Kolesov S.G., Chernetsky Yu.P. Lyophilization of microorganisms and biological products. // In the book Veterinary drugs edited by D.F.Osidze 1981. p. 24-33
Okhapkina V.Yu., Shabalin B.A. Methods for maintaining microbial cultures. Part 1. Cryopreservation // Theoretical and Applied Ecology. 2009. № 1. P. 18–26.
Arkadieva Z.A. Factors affecting the viability and properties of microorganisms in different storage methods // Biological sciences. 1983. № 4. P. 93–95.
Timoshin A.A., Rappoport A.I., Becker M.E. Effect of drying on thermally induced structural rearrangements of the cytoplasmic membrane of yeast cells // Microbiology. 1990. V. 59. Issue 2. P. 679–682.
Chervyakova N.S., Osin A.V. Establishing the authenticity of reference strains of pathogenic microorganisms using an automatic microbiological analyzer Vitek-2. Problems of especially dangerous infections. 2017.1.Р. 100-104.
Pokhilenko V.D., Baranov A.M., Detushev K.V. Methods of long-term storage of collection cultures of microorganisms and development trends. Proceedings of higher educational institutions. Volga region. Medical sciences. 2009; 4 (12) p. 99–121.
Egorova T.A., Klunova S.M., Zhivukhina E.A. Fundamentals of Biotechnology. - 3rd edition - M .: Academy, 2006 .- 208 p.
Kotlov S.A. Optimization of cryoprotectants for lyophilization of SALMONELLA vaccine strains // Biological journal: electronic scientific journal. –2019 – №5(5). URL: https://bio-j.ru/archive/5/124.
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