Articles
| Open Access |
DOI: Comparative Analysis Of The Results Of The Endoscopic Treatment Of Gastroduodenal Ulcerative Bleeding
Dilshodbek Mamadaliyevich Khakimov , Doctor Of Medical Sciences (DSc), Head Of The Department Of General Surgery Faculty Of Postgraduate Education, Andijan State Medical Institute, Uzbekistan Muzaffar Madaminovich Nosirov , PhD, Associate Professor Of The Department Of Endosurgery Faculty Of Postgraduate Education, Andijan State Medical Institute, Uzbekistan Bekzodbek Baxodirovich Karaboev , Junior Researcher Of The Department Of General Surgery Faculty Of Postgraduate Education, Andijan State Medical Institute, UzbekistanAbstract
The study includes 557 patients with ulcer of the stomach and duodenal intestine complicated by bleeding. The control group was 290 patients, of which 48 patients with active bleeding were performed by standard endoscopic hemostasis techniques, and in 242 cases, when verifying stopping bleeding, endoscopy was limited to the diagnostic step with subsequent conservative patient management. The main group includes 267 patients in addition to endoscopic hemostasis with active bleeding (46 patients), the manipulation was supplemented with the implementation of the proposed method of endoscopic treatment of gastroduodenal bleeding of ulcerative genesis. When revealed bleeding (221 patients), endoscopic intervention was also accompanied by the implementation of the proposed method.
The application of the composite polymer material over the ulcerative defect contributed to a decrease in the frequency of the nearest recurrences of hemorrhagic syndrome from 9.0% to 1.9%, reduce the need to perform operational treatment from 6.6% to 1.1% and levity indicator from 1.7% up to 0.7%, which generally affected the increase in the share of patients discharged without complications from 90.7% to 97.8% and reducing the timing of the hospital phase of treatment.
Keywords
Gastroduodenal ulcerative bleeding, applique, endoscopic hemostasis
References
Kempenich JW, Sirinek KR. Acid Peptic Disease. Surg. Clin. North Am. 2018 Oct;98(5):933-944.
Lau JY, Sung J, Hill C, Henderson C, Howden CW, Metz DC. Systematic review of the epidemiology of complicated peptic ulcer disease: incidence, recurrence, risk factors and mortality. Digestion. 2011;84(2):102-13.
Lolle I, Muller MH, Rosenstock SJ. Association between ulcer site and outcome in complicated peptic ulcer disease: a Danish nationwide cohort study. Scand J Gastroenterol. 2016;51(10):1165-1171.
Peiffer S, Pelton M, Keeney L, et al. Risk factors of perioperative mortality from complicated peptic ulcer disease in Africa: systematic review and meta-analysis. BMJ Open Gastroenterol. 2020;7(1):e000350. Published 2020 Feb 17. doi:10.1136/bmjgast-2019-000350.
Hagel AF, Albrecht H, Nägel A, Vitali F, Vetter M, Dauth C, Neurath MF, Raithel M. The Application of Hemospray in Gastrointestinal Bleeding during Emergency Endoscopy. Gastroenterol Res Pract. 2017;2017:3083481.
Prei JC, Barmeyer C, Burgel N et al. EndoClot Polysaccharide Hemostatic System in Nonvariceal Gastrointestinal Bleeding: Results of a Prospective Multicenter Observational Pilot Study. J Clin Gastroenterol. 2016;50:e95–e100.
Barkun AN, Martel M, Toubouti Y, Rahme E, Bardou M. Endoscopic hemostasis in peptic ulcer bleeding for patients with high-risk lesions: a series of meta-analyses. Gastrointest Endosc. 2009 Apr; 69(4):786-99.
Fujishiro M, Iguchi M, Kakushima N, et al. Guidelines for endoscopic management of non-variceal upper gastrointestinal bleeding. Dig Endosc. 2016;28(4):363-378.
Park JC, Kim YJ, Kim EH et al. Effectiveness of the polysaccharide hemostatic powder in non-variceal upper gastrointestinal bleeding: Using propensity score matching. J Gastroenterol Hepatol. 2018;33:1500–1506.
Haddara S, Jacques J, Lecleire S et al. A novel hemostatic powder for upper gastrointestinal bleeding: a multicenter study (the "GRAPHE" registry) Endoscopy. 2016;48:1084–1095.
Vitali F, Naegel A, Atreya R, et al. Comparison of Hemospray® and Endoclot™ for the treatment of gastrointestinal bleeding. World J Gastroenterol. 2019;25(13):1592-1602.
Article Statistics
Copyright License
Copyright (c) 2021 The American Journal of Medical Sciences and Pharmaceutical Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.