In the contemporary world, there is a rapid increase in the invention and application of a large number of medications (drugs) in practical health care, which, on the one hand, can cure and/or enhance the patient's condition, but also do substantial harm to his health. The purpose of this study was to add to the body of knowledge on polypragmas that develop following nonsteroidal therapy in rats. Gastric tissue was morphologically examined in 55 rats to attain the aim. The findings revealed that nonsteroidal therapy resulted in an increase in the amount of mucous membranes and lymphoid follicles, proliferation of vascular wall cells, and poor stratification of connective tissue cells in the stomach.

Stomach, non-steroidal anti-inflammatory drugs (NSAIDs), morphology

Agapova N.G. (2007). About medicinal gastroduodenal ulcers. Mystetstvo lykuvannya. (2)38.

Gelfand B.R., Guryanov A.V., Martynov A.N. et al. (2005). Prevention of stress damage to the gastrointestinal tract in critically ill patients. Consilium medicum. 7(6). pp. 464–67.

Zhuraeva G.B. (2015). The activity of pathomorphological changes in the intestinal lymphoid tissue under the influence of acute intestinal infections. Yakutsk Medical Journal. 2(50) pp. 63-67.

Zhuraeva, G.B., Saidov, A.A., & Israilov, R.I. (2015). The dependence of morphological and morphometric changes in the mucous membrane in acute intestinal infection on the type of pathogen. Youth Innovative Bulletin, 4(1), pp.193-195.

Karateev A.E. (2006). Treatment and drug prevention of NSAID gastropathy: basic provisions. Pharmateka, 6(121). pp.37–45.

Sapin M.R. (2012). The lymphatic system and its role in immune processes. Morphology, 141(3), p. 139.

Safonova M.A. (2009). Hygienic assessment of the impact of technogenic environmental factors on the development of chronic gastroduodenitis in children (on the example of the Perm Territory): Avtoref.dis.kan.nauk Perm,; 24.

Teshaev Sh.Zh., Khudoiberdiev D.K., Teshaeva D.Sh. (2018). The impact of exogenous and endogenous factors on the stomach wall. Problems of biology and medicine. 4(104). pp. 212-214.

Teshaev Sh.Zh., Toshmamatov B.N. (2021). Morphofunctional characteristics of the stomach in polypharmacy. Journal of a new day in medicine. 3. pp.227-232.

Chava S.V. (2004). Reactive changes in immune structures in the wall of the small intestine. Morphological statements, 1-2, p. 114-115.

Ahrorova, K. D. (2021). Morphofunctional properties of the lymphoid structures of the spleen in norm and under the influence of various factors. Academicia: An International Multidisciplinary Research Journal, 11(1), 459-465.

Andersson Т, Andren N, Cederberg С, et al. (1990). Bioavailability of omeprazole as enteric coated granules in conjunction with food on the first and seventh day of treatment. Drug Invest. 2. pp.184–88.

Andersson T, Cederberg C, Heggelund A. (1991). The pharmacokinetics of single and repeated once daily dose of 10, 20 and 40 mg omeprazole as enteric coated granules. Drug Invest; 3, pp.45–52.

Siurala М., Voris K. Gastritis. (1999). In: Scientific Foundations of Gastroenterology, edited by W.Sircus and A. N. Smith, 357-369, London, William Heinemann Medical Books Ltd.