Articles
| Open Access |
DOI: Risk Of Pulmonary Artery Thrombosis In Type 2 DM Patients Hospitalized With Covid-19
Nodirbek Ilkhomjon Ogli Yakubov , Assistant, Department Of Oncology And Medical Radiology, Andijan State Medical Institute, Andijan, Uzbekistan Dilfuzahon Zakirjanovna Mamarasulova , Md, Associate Professor, Head Of The Department Of Oncology And Medical Radiology, Andijan State Medical Institute, Andijan, Uzbekistan Nataliya Gamletovna Dadamyants , Ph.D., Senior Researcher, Republican Scientific Center For Emergency Medical Aid, Head Of Department Of Ultrasound Diagnostics, Tashkent, Uzbekistan Anvar Arabbayevich Dalimov , Doctor Of The Andijan Branch Of The Republican Specialized Medical Center For Emergency Care, UzbekistanAbstract
For the first time on the Fergana Valley model, prognostic markers of the risk of thrombotic complications in COVID-19 patients with type 2 diabetes were studied. It was found that the level of glycemia, the concentration of proinflammatory cytokines IL-6, ferritin and CRP, and the marker of thrombus formation - d dimer, have a prognostic significance, with the maximum prognostic significance of the concentration of CRP. The prognostic significance of ultrasound in the aspect of thrombosis of the branches of the PA in patients with COVID-19 against the background of type 2 diabetes was established. Predictor markers are mean PA pressure, LV myocardial mass index, signs of increased intraventricular pressure in the RV, and evidence of peripheral venous thrombosis.
Keywords
COVID-19,, pulmonary artery thrombosis, type 2 DM.
References
Ackermann M, Verleden SE, Kuehnel M, et al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in COVID-19.// N Engl J Med .-2020.-383(2).-120–128.
Al-Samkari H, Karp Leaf RS, Dzik WH, et al. COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection.// Blood .-2020.-136(4).-489–500.
American Society of Hematology. COVID-19 and VTE/anticoagulation: frequently asked questions. Available from: https://www.hematology.org/covid-19/covid-19-and-vte-anticoagulation. Accessed 13 June 2020.
Buonsenso D, Raffaelli F, Tamburrini E, Biasucci DG, et al. Clinical role of lung ultrasound for the diagnosis and monitoring of COVID-19 pneumonia in pregnant women. //Ultrasound Obstet Gynecol. -2020.
Carestia A, Frechtel G, Cerrone G, et al. NETosis before and after hyperglycemic control in type 2 diabetes mellitus patients.// Plos One.- 2016.-11(12).-e0168647.
Cariou B, Hadjadj S, Wargny M, et al. CORONADO Investigators. Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study. //Diabetologia. -2020.-63(8).-1500-1515.
Fraissé M, Logre E, Pajot O, Mentec H, et al. Thrombotic and hemorrhagic events in critically ill COVID-19 patients: a French monocenter retrospective study. //Crit Care.- 2020.-24(1).-275.
Gervaise A, Bouzad C, et al. Acute pulmonary embolism in non-hospitalized COVID-19 patients referred to CTPA by emergency department.// Eur Radiol.- 2020.-30(11).-6170–6177.
Girard P, Sanchez O, Leroyer C, et al. Deep venous thrombosis in patients with acute pulmonary embolism: prevalence, risk factors, and clinical significance.// Chest.- 2005.-128(3).-1593–1600.
Han H, Yang L, Liu R, Liu F, et al. Prominent changes in blood coagulation of patients with SARS-CoV-2 infection. //Clin Chem Lab Med. -2020.
Hardaway RM, Williams CH, Marvasti M, et al. Prevention of adult respiratory distress syndrome with plasminogen activator in pigs. //Crit Care Med. -1990.-18.-413–1418.
Article Statistics
Copyright License
Copyright (c) 2021 The American Journal of Medical Sciences and Pharmaceutical Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.