The work of reflection on learning and the important role the brain plays establishes a referential analysis with the goal of investigating and knowing everything related to the human being's knowledge and the activities he performs during the process of acquiring knowledge. These highlights how important it is to know this organ and how the content can be changed. Additionally, brain plasticity, which is the adaptation of changes or modifications that occur during the learning process, is emphasized. Significant learning is procured through great instructive practices and the utilization of dynamic philosophies, where a proper climate is laid out, in which inspiration assumes a significant part and procedures are as per the substance to be dealt with, which is preposterous without the cerebrum in question. The work is synthesized through analytical research and the use of the inductive method by analyzing the problem from the general to the specific, defining the elements that interfere with learning and the brain's imprint, the relationship with society in the cognition of contents, and the skills necessary for the development in various areas of knowledge. In addition, bibliographic resources are used to relate to the topic being discussed. The work's objective is to examine how the teaching-learning process affects the brain.