Acute appendicitis is a common surgical emergency characterized by inflammation of the appendix. While the condition primarily affects the appendix, it can lead to systemic effects and potential complications. The liver, being an important organ involved in various metabolic processes, may be affected by the inflammatory response associated with acute appendicitis. This study aims to evaluate the impact of acute appendicitis and its complications on liver function test parameters. Liver function tests (LFTs), including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TB), and direct bilirubin (DB), were measured in patients diagnosed with acute appendicitis. The LFT results were compared between patients with uncomplicated appendicitis and those with complications such as perforation or abscess formation. Statistical analysis was performed to identify any significant differences in the liver function parameters between the two groups. The findings of this study provide insights into the potential effects of acute appendicitis and its complications on liver function, which may aid in the early detection and management of hepatic abnormalities in patients with this condition.

Acute appendicitis, complications, liver function tests

Sisson, R. G., Ahlvin, R. C. & Harlow, M. C. Supercial mucosal ulceration and the pathogenesis of acute appendicitis. Am. J. Surg. 122, 378–380 (1971).

Mishra, B. M., Nayak, M. K., Mishra, S., Sahu, P. & Das, D. Role of liver function test parameters in acute appendicitis and its complication: a prospective study. Int. Surg. J. 6, 193 (2018).

Estrada, J. J. et al. Hyperbilirubinemia in appendicitis: A new predictor of perforation. In Journal of Gastrointestinal Surgery vol. 11 714–718 (2007).

Yadav, S. & Chandra, K. Liver function test as a marker for acute appendicitis. Janaki Med. Coll. J. Med. Sci. 3, 31–36 (2016).

Ramasamy Ramu, T., Chinnakkulam Kandhasamy, S., Andappan, A. & Sankar T, B. A Prospective Study on the Diagnostic Value of Hyperbilirubinemia as a Predictive Factor for Appendicular Perforation in Acute Appendicitis. Cureus 10, (2018).

Subedi, N., Dangol, U., Adhikary, M., Pudasaini, S. & Baral, R. Acute appendicitis: a 2- year review of clinical presentation and histopathology. J. Pathol. Nepal 1, 104–107 (1970).

Khan, S. Effect of Acute Appendicitis on routine Liver Function Tests. J. Inst. Med. Nepal 30, 41–45 (2008).

Sand, M. et al. Diagnostic value of hyperbilirubinemia as a predictive factor for appendiceal perforation in acute appendicitis. Am. J. Surg. 198, 193–198 (2009).

Giordano, S., Pääkkönen, M., Salminen, P. & Grönroos, J. M. Elevated serum bilirubin in assessing the likelihood of perforation inacute appendicitis: A diagnostic meta- analysis. International Journal of Surgery vol. 11 795–800 (2013).