This article presents the results of a study of the effect of cynoroside and thermopsoside on respiration and oxidative phosphorylation of mitochondria in vitro. It has been established that cynoroside increases mitochondrial respiration, especially during glutamate oxidation, and, on the contrary, decreases with succinate.

Flavonoids, Cynoroside, Thermopsoside

Rice-Evans C.A. Parker L. (Eds.) Flavonoids in Health and Diseases. Marcel Dekker, New York, 1997.

Middleton E., Kandaswami C., Theoharides T. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart diseases and cancer. Pharmacol. Rev. 2000. V. 52. P. 673-751.

Blakhei A.S., Shutyy L.P. Phenolic compounds of plant origin. Moscow: Mir, 1997.

Bagchi D., Bagchi M., Stohs I. et al. Cellular protection with proanthocyanidins derived from grape seeds // Ann. N. Y. Acad. Sci. 2002. V. 957. P. 260-270.

Checkman I.S. Flavonoids: clinical and pharmacological aspect // Phytotherapy in Ukraine. 2000. No. 2. S. 3-5.

Yalkut SI, Tsipriyan VI Preventive nutrition in oncology. Moscow: Polygraph Tech Service, 2002.

Baraboy V.A. Biological action of plant phenolic compounds. Kiev: Nauk. dumka, 1984.

Chekman I.S., Lipkan G.M. Herbal remedies. Kiev: Kolos, ITEM. 1993.

Schneider W.C., Hogeboom G.N. Cytochemical studies of mammalian tissues the isolation of cell components by differential centrifugation. Cancer. Res. 1951. V. 19. P. 1 - 22.

Chance B., Williams G.R. Respiratory enzyme in oxidative phosporylation. 1V. Respiratory chain. J. Biol. Chem. 1955. No. 2. P. 429-444.

Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951. V. 193. N. 1. P. 265-274.

Babadzhanova S.Kh., Shirinova I.A., Almatov K.T., Akhmerov R.N., Allamuratov Sh.I., Azimov D.A. The principles of increasing the vitality of the organism with hypometabolic agents. Dokl. AN RUz., 2000, No. 7, p. 58-60.

Babadzhanova S.Kh., Almatov K.T., Shirinova I.A., Akhmerov R.N. The influence of various metabolites on mitochondrial energy links and the vitality of the organism. Materials of the international scientific-practical conference "Ecological foundations of studying the problems of the Aral Sea region", Nukus, 1999, v.1, p. 86-88.

Babadzhanova S.Kh., Shirinova I.A., Almatov K.T., Akhmerov R.N., Zaitova A.Z., Ishanova M., Allamuratov Sh.I. Elucidation of tolarentogenic activity in different groups of hypometabolic agents. University Bulletin. Dushanbe, 2000, No. 1, p. 63-67.

Asanova K.A. Energy of animals and the role of mitochondrial enzyme systems in increasing vitality during hypoxia. Abstract of the thesis. Cand. dis., Tashkent, 2002, 23p.

Asanova K.A., Nurdinov Sh.Sh. Mitochondrial mechanism for increasing the vitality of the organism and hypoxia. Mater. LX international scientific student conference. Novosibirsk, 2002, p. 157-159.

Shirinova I.A., Yusupova Sh., Igamberdieva F., Klemesheva L.S., Almatov K.T. Influence of Central Asian cobra venom on the content of phospholipids in rat liver and heart mitochondria and the protective effect of benzonal. Biomedical Chemistry of the Russian Academy of Medical Sciences. Moscow, 2002, No. 5, p. 44-48.

Mamajanov M. M. et al. Influence of the venom of the Central Asian cobra on the activity of rotenone sensitive and insensitive NAD. H-oxidases of rat liver mitochondria and their correction with flavosan // Theoretical & Applied Science. - 2020. - No. 2. - S. 624-629.

Mamajanov M. M., Mirzakulov, S. O., Almatov, K. T., & Botirov, E. K. (2017). Correction of physical-biochemical processes in the organism by flavosan. European science review, (11-12), 15-23.