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DOI: Synthesis Of 2,5-Dimersapto-1,3,4-Thiadiazol Products
Jololiddinov Fazliddin Yuldashali Ugli , Trainee-Researcher Of Academic Institute Of Bioorganic Chemistry Named After O.S Sodikov Laboratory Of Low Molecular Weight Biologically Active Compounds, Uzbekistan Xaitboev Xamid , Senior Researcher, Candidate Of Chemical Sciences Of Academic Institute Of Bioorganic Chemistry Named After Os Sodikov Laboratory Of Low Molecular Biologically Active Compounds, Uzbekistan Boboev Baxrom Nurillaevich , Doctor Of Chemical Sciences, Professor, Head Of The Department Of Chemistry Of Natural Compounds, Faculty Of Chemistry, National University Of UzbekistanAbstract
Potentially bioactive 2,5-bis derivatives of 1,3,4-thiadiazole with alkaloid moieties were synthesized byreaction of 1,3,4-thiadiazol-2,5-dithiol with N-acryloyl-substituted derivatives of the alkaloids anabasine,cytisine, and D-pseudoephedrine.1,3,4-Thiadiazole-2,5-disulfonic acid was synthesized by oxidation of 2,5-dimercapto-1,3,4-thiadiazole,and onium salts of this acid were prepared by its reactions with selected alkaloids and secondaryamines.
Keywords
Synthesis 1,3,4-thiadiazol-2,5-dithiol, alkaloids
References
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