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| Open Access | ASSESSING THE FEASIBILITY OF CERVICAL VERTEBRAL AUGMENTATION IN SHEEP: A NOVEL ANIMAL MODEL USING A PTH DERIVATIVE BIOACTIVE MATERIAL
Jason W. Klein , Graduate School for Cellular and Biomedical Sciences, University of Bern, SwitzerlandAbstract
Cervical vertebral augmentation has emerged as a promising technique for the treatment of vertebral fractures and instability. To evaluate the feasibility and safety of this procedure, we developed a novel animal model using sheep and a parathyroid hormone (PTH) derivative bioactive material. This study aimed to assess the effectiveness of the PTH derivative in promoting bone regeneration and stabilization of cervical vertebrae in the sheep model. A standardized surgical procedure was performed to create vertebral defects, and the PTH derivative bioactive material was then applied to the affected area. Postoperative assessments included radiographic evaluation, histological analysis, and biomechanical testing. The results demonstrated the viability of the novel animal model for cervical vertebral augmentation and suggested the potential benefits of the PTH derivative in promoting bone healing and enhancing vertebral stability. These findings provide valuable insights for future translational research and clinical applications of cervical vertebral augmentation techniques.
Keywords
Cervical vertebral augmentation, animal model, parathyroid hormone derivative
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