One of the main causes of chronic inflammatory periodontal diseases is dental deposits, which are formed as a result of improper oral hygiene, changes in the quantitative and qualitative composition of the oral micro flora, and a decrease in the body's resistance. Compliance with individual oral hygiene is an important step in the successful treatment and prevention of periodontal disease.

As a result of electron-microscopic examinations, enamel prisms in the transverse position, they look like arches and roofs. When we cross the enamel prisms, we see diagonals, polygonal prisms. When they are parallel, when they are cut lengthwise, we see the planes, the fibers parallel to each other. Because enamel prisms are curved in an S-shape, some appear transverse and others parallel when cut. The result is light and dim roads, called Schroeder roads.

The association between HP infection and CAH development suggested by the Correa cascade is supported by several cohort studies. To diagnose and determine the severity of atrophy at the Center, patients underwent a serological analysis by ELISA method in the clinical and biochemical laboratory of the State Institution "RSNPMCT and MR". Analyzes were taken in 69 (58.5%) patients, including 35 (50.7%) with CAH, 34 (49.3%) with CNG. Analysis of the non-invasive indicator of the level of pepsinogens in patients with CAH determined that severe atrophy was detected in 20%, moderate atrophy - 42.9%, weak atrophy - 34.3%, and no atrophy was found in 2.9% of patients. The pepsinogen parameters in patients with CNG were also as follows: PG I was within 95.4 ± 7.2 μg / L, PG II 14.5 ± 1.3 and PGI / PGII 6.6 ± 0.2. Pepsinogen values were more pronounced in patients with CAH: with a pronounced degree of atrophy, PGI was 8.7 ± 0.1 μg / l and PGI / PGII was 1.1 ± 0.1; with moderate atrophy 16.6 ± 0.9 μg / l and 1.6 ± 0.1; with mild atrophy 27.2 ± 1.5 and 2.3 ± 0.2, respectively.

Meaning and role of mycoplasma infection for children with bronchial asthma small studied.  By us was inspected 39 children with BA in age from 2 to 14, from them 27 (69,2%) boys and 12 (30,8) girls. Obtained data from PChR testing is shown: among the children of patients with BA for 33,3% (13/39) patients found out M. pneumoniae.; for 66,7% (26/39) patients and for all children of control group M. pneumoniae. it is not discovered (table.№1). For children in a range 2-5, the more than half (53,8%) of children-asthmatics was got positive results of PChR; among the investigated children in age 6-14, only at 46,2% patients had M. pneumonia. Except it, among patients with BA, for 69,2% boys and 31% girls made the positive result of  PChR, and correlation of sexes was made by 2,2: 1.

The study of pathogenetic predictors of the development of anxiety-depressive disorders in myocardial infarction will make it possible to develop ways of their correction, thereby reducing the frequency of complications of the postinfarction period. Clinical studies were based on the examination of 58 patients with MI (mean age 59.2 ± 4.7 years) who were admitted to the cardiological hospital for treatment, and the observation data for them at the stage of rehabilitation. On the basis of the presence of anxiety-depressive symptoms, the patients were divided into 2 groups. The first control group consisted of 14 patients with MI without depressive disorders. The second group included 44 age-matched patients who underwent MI with symptoms of anxiety and depression without comorbid cardiovascular pathology. The diagnosis of myocardial infarction was based on the results of clinical examination, ECG changes, laboratory parameters, and echocardiographic data. In order to assess the mental status of the subjects, subjective methods were used: the hospital anxiety and depression scale (HADS) for patients in a somatic hospital and recommended for use in patients with post-infarction period. Markers of endothelial dysfunction in blood plasma were determined by enzyme immunoassay using appropriate test systems. Since fibrinogen is one of the key factors in the blood coagulation process, disorders of which with a tendency to thrombotic changes are one of the central links in the pathogenesis of MI, the level of oxidized fibrinogen with parameters of the functional state of endothelial cells was studied. In the early stages after myocardial infarction, the level of oxidized fibrinogen was 1.7 times higher in the study group compared to the control, although, in general, the level of fibrinogen in the study group was within normal values. In the subsequent periods of the study, the level of oxidized fibrinogen was in high values and, on average, exceeded the control values by 1.64 times. Since one of the key roles in the development of dysfunction and endothelial destruction is assigned to the factors of oxidative stress, a correlation analysis of the relationship between the oxidative modification of fibrinogen and the parameters of endothelial function was carried out. A direct correlation was shown between the level of oxidized fibrinogen and the level of Endothelin-1 (r = 0.78, p <0.01), and a direct correlation with the level of von Willebrand factor (r = 0.365, p <0.01). Linear regression analysis confirmed the associations of oxidized fibrinogen with the indicated parameters of endothelial dysfunction. Based on the results obtained, it can be emphasized that with MI, in patients with developed DS, along with increased oxidative changes in lipids and plasma proteins, there is also a significant oxidative modification of fibrinogen, which does not depend on the concentration of fibrinogen. Oxidized fibrinogen potentiates potentially prothrombogenic changes in the vascular-platelet link of hemostasis, in particular, the acceleration of leukocyte-platelet aggregation. The revealed signs of thrombotic and hypercoagulant hemostasis disorders in patients with MI with depressive disorders, such as signs of endothelial dysfunction, elevated von Willebrand factor levels, are associated with oxidative changes in plasma fibrinogen in patients with MI with the development of DS, have a high diagnostic value.

In recent years, research has been carried out to study the problems of improving the organization of dental care for both the General population and individual categories of industrial workers^4,6.

However, to date not carried out in-depth studies on the problems of improvement of dental care to employees of the chemical industry in the new socio-economic conditions of development of industrial complex and reform of the health system, there is no comprehensive study of the current status of dental service medical-sanitary unit (MSCH) large enterprises, comparison of availability and quality of dental care to employees at the place of residence and place of work.

The purpose of this review is to study the dental morbidity of chemical workers, develop measures to improve their dental health and improve the quality of life.

At the present stage of development of the industrial complex of our country, a number of large enterprises have the opportunity to organize dental care for employees, primarily with harmful working conditions, at a higher level. At the same time, the implementation of the preventive orientation in dental care for the working population remains an unsolved problem^2,3.

The successful functioning of any medical service in modern conditions is possible only with the optimal interaction of all parts, all elements of the health system depends largely on the level of organization and management of medical institutions to optimize their work^7,8.

Keywords: Condition of the mucous membrane of the oral cavity, the hard tissues of teeth and paradontium, taste analyzer, unfavorable factors of production.

Material And Methods Of Research: It is planned to conduct a study of 120 workers of JSC "samarkandkime" - the main group, as well as 115 patients who applied to polyclinic No. 10 and are not related to the chemical industry - the control group.

The data that was received was subjected to statistical processing using the Microsoft Excel application package. The reliability of the difference in parameters was determined by the student's criterion.

Results and discussion.Currently, the issues of dental health for workers in various industries are relevant.

Various harmful factors of production can have a negative impact on human health, including on the tissues of the teeth, periodontal, oral and lip mucosa.

The clinical characteristics and the course of alcohol dependence, preceding the formation of a complicated sonata were studied in 60 patients. A study of the clinical characteristics and the course of alcohol dependence preceding the formation of a complicated sonata was carried out in 60 patients. It has been established that in most cases, the introduction to sonatas occurs against the background of an expanded stage of previous alcoholism, characterized by a rapid rate of development and high progression.

Recurrent miscarriage (RMP) is an unsolved problem in modern gynecology and obstetrics. A growing body of experimental research suggests that endometrial immune dysregulation may be responsible for many, if not all, cases of PNL of unknown etiology. This article discusses the main immunological disorders that occur in PNL.

A 70-year-old female visited our hospital last summer with a history of painless, progressive diminition of vision in the left eye for the the past 1 years. She complained of developing sudden pain in the left eye for the past three days. There was no other significant history. The significant findings on her left eye examination was a visual acuity of perception of light with accurate projection of rays, corneal edema, hypermature cataract seen through a hazy media, deep anterior chamber and floating white lens particles looking like minute snow flakes filling the aqueous and forming a pseudohypyon(figure 1).

Hyperprolactinemia syndrome is one of the most common neuroendocrine disorders. In the structure of endocrine pathology, it ranks third after diabetes mellitus and thyroid diseases. The article is devoted to the topical issues of diagnosing hyperprolactinemia syndrome depending on the cause of the development of this syndrome.

There are many different ways to examine dental patients, especially those with oral mucositis. In general, they are divided into subjective (question and answer with the patient, questionnaire), objective (seeing the general condition of the patient, the oral cavity). Objective vision is primary and secondary, respectively auxiliary methods.

To study the effectiveness of teaching "self-care" and "self-control" in elderly and senile patients with chronic heart failure. The study included 107 patients with chronic heart failure. The training program was attended by 54 patients who made up the study group. 53 untrained patients made up the control group. These sessions were conducted with patients for 7 days, 1 hour per day. To assess the effectiveness of the training program, adherence to treatment was assessed using the Morisky-Green scale and the quality of life was assessed using the Minnesota questionnaire on the quality of life of patients. Results. During 1 year of follow-up, feedback was interrupted with 17 patients (15,8%) due to various reasons. Out of 90 subjects of observation, only 6 patients (6,7%) died due to the deterioration of their condition and the development of associated conditions. The assessment of the number of visits by patients to family polyclinics showed a generally satisfactory level of clinical examination in the study group - the average rate of planned visits was 3,2. In the control group, the average number of visits was 2,5 per year. There was a statistically significantly lower number of unplanned visits to the study group compared to patients from the control group. As a result, there was a significant decrease in the number of unplanned visits in the intervention group as a whole. Conclusion. The program of training elderly and senile patients on the aspects of self-medication and self-control in chronic heart failure is effective in improving the control of their adherence to therapy and the prognosis of the disease.

Based on the results of clinical and neurological studies, the use of mavix in the complex treatment of elderly patients with ischemic stroke is justified. The obtained data on the differentiation of the therapeutic response contribute to the optimization of therapy for acute ischemic stroke in order to stop or slow down its progression and maintain the quality of life of both the patients themselves and their families.

A study of 341 patients with an established diagnosis of acute myocardial infarction was carried out. The patients are divided into 2 groups. The first, main, included 233 patients with acute myocardial infarction, who subsequently developed depressive disorders, confirmed clinically and using diagnostic scales; the second group consisted of 108 patients who also had acute myocardial infarction, but did not subsequently suffer from symptoms of depression. Clinical and dynamic observation of patients in the postinfarction period was carried out with control of the condition in a month, three months, six months, 12 months after myocardial infarction. Clinical observation was used to detect the presence of symptoms of depression. Among patients with MI with DS in the first days after MI, more than half (51.1%) reported a permanent decrease in mood more often than other symptoms, i.e. these patients showed an affective component of depression, while the ideator component of depression, which manifested itself in thinking retardation to one degree or another, was in 27.5% of patients, motor retardation (motor component) was detected in 21.5% of those observed. In patients with almost the same frequency, the anxious and melancholic type of affect was noted (47.0% and 41.2%, respectively), the dysphoric type of affect was found in 11.8% of cases, which is 4 times less than anxious and 3.5 times less than the melancholic type. In cases of prolonged depression, the severity of affective disorders more often directly correlated with the severity of the physical condition. If not so long-term depressive episodes were largely due to "their own vision of the disease", the severity of their symptoms depended on the conversation with the doctor and the information received from him, the degree of awareness of his diagnosis, possible complications, and not very much depended on the general somatic status itself. then the course of prolonged depression in patients worsened with the aggravation of the cardiological and general somatic condition of patients. Psychosomatic parallelism in the majority of protracted depressions was manifested by the generalization of asthenic symptom complexes (increased general weakness, intolerance to exertion, lethargy, adynamia, severe daytime sleepiness in combination with early insomnia) with deterioration of the somatic state. At the same time, it was noted that with prolonged depression, there were always more or less pronounced cognitive disorders (reduced memory for past events, limited ability to comprehend what was happening around, remember new information, impaired concentration). Postinfarction depressive episodes lasting up to six months can be attributed to nosogenies; depressive episodes of postinfarction genesis with a protracted course, probably with a high degree of confidence can be attributed to somatogenias.

The article presents the results of preoperative preparation, anesthesia and surgical treatment of patients operated on for non-toxic nodular goiter. A new approach to preoperative preparation for thyroid surgery is described. The effectiveness in the preoperative period of using the modified method of preoperative preparation using sibazon and droperidol and anesthesia with the use of ketamine and the advantages of this method compared with other methods of general anesthesia are shown.

Goal of this study of the relationship between alcohol use, severity of psychiatric symptoms and the number of verified medical diagnoses. The study was that self-reporting of medical history is less accurate in patients with comorbid alcohol dependence and schizophrenia compared with patients with alcohol dependence only or with control. 46 patients with schizophrenia or schizoaffective disorder and concomitant alcohol dependence recruited from the Bukhara Regional Psychoneurological Dispensary. 27 patients suffered from schizophrenia, and 19 patients from schizoaffective disorder.

Hereditary coagulopathies characterized by reduced blood clotting occupy a special place among diseases of the blood system. The most common of these are hemophilia and Willebrand's disease. Hemophilia-the disease of "royals" - is an old, but still relevant disease.

Hereditary coagulopathies, characterized by reduced blood clotting, occupy a special place among diseases of the blood system. Based on who data and the likely frequency of research on these diseases, the prevalence of hemophilia ranges from 3 to 25 patients per 10,000 population.

Few studies of the oral cavity in patients with hemophilia have shown a high level of dental diseases, poor hygiene of the oral cavity. This is due to the lack of proper oral care, and dispensary monitoring, fear of prolonged bleeding after dental manipulations. For this reason, dentists try to avoid treating dental diseases in this category of patients.

At the same time, modern achievements of medical science in the field of Hematology and the development of effective replacement therapy allow to prevent almost all types of bleeding.

However, this group of patients is still unable to receive timely and high-quality dental treatment and prevention, which largely determines the high prevalence of inflammatory diseases of the maxillofacial region.

All of the above is evidence of the presence of many predisposing factors of damage to the dental system in patients with hemophilia, as well as the need for preventive, therapeutic, including orthopedic dental measures for this category of patients.

We investigated the associations between the host HLA-DQ variation and the prevalence of H ruli in
the Indonesian population with an H. pylori-infected level of 11.2% in people living in the Bukhara
region. It was noted that individuals carrying the DQB1 * 0401 genotypes are at significantly greater
risk of developing H infection. .lori compared to individuals with the DQB1 0301 genotypes. The DQA1
or DQB1 haplotypes were not associated with H. pulori infection.

This scientific work is devoted to the study of the results of the action of pesticides on the organism of experimental animals. At the beginning, a brief review of the literature devoted to this problem is given. The author also describes a method for determining the content of toxic substances in the liver tissues of experimental animals. The corresponding conclusions on the simplicity of the method are made.

Pelvic organ prolapse (PTP) - pelvic floor and organ omission syndrome pelvic floor in isolation or in combination, which is extremely negatively affected by the quality of life of patients. According to world data, between 2.9 and 53% of women report some form of PTP. Up to 47% of pelvic organ prolapsed patients are women of working age. According to the Women Health Initiative Study, among 16,616 women of perimenopaus age, the incidence of uterine prolapsed was 14.2%, cystocele was 34.3%, and reconcile was 18.6%. In most cases, PTP is almost asymptomatic, which indicates its greater prevalence in the population.

Long-term studies of clinical hypnosis at the "Doctor D" hospital in Uzbekistan demonstrate the effectiveness of this method in the treatment of various sexual disorders. This is confirmed by the change in the behavior of the subject in interpersonal relationships. Neurophysiological monitoring objectively confirms the change in the biorhythmic activity of the brain towards positive emotions, with the resurrection of feelings in the relationship of spouses.