Medical Science
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DOI: Compensation Mechanisms Of The Organism In Hemolytic Anaemia
Azimova Sevara Bakhodirovna , Tashkent State Medical University, Department of Normal and Pathological Physiology, Uzbekistan Tajibayeva Rana Bakhodirovna , Tashkent State Medical University, Department of Normal and Pathological Physiology, Uzbekistan Yakubjonov Kudratilla Khojiakbar oglu , Tashkent State Medical University, 1st year master's degree in morphology, UzbekistanAbstract
Hemolytic anemia is a pathological condition characterized by the direct or indirect destruction of erythrocytes before their normal lifespan, manifested by a combination of anemia and laboratory signs of hemolysis in the peripheral blood. The purpose of this article is to provide an in-depth study of various compensatory and adaptive mechanisms activated by the human body in conditions of hemolytic anemia. In patients with hemolytic anemia, the body tries to compensate for oxygen deficiency and minimize the negative consequences of hemolysis through a number of complex physiological processes. Among these compensatory mechanisms are such important processes as adaptation of the cardiovascular system, increased hematopoietic activity, a shift of the oxygen-hemoglobin dissociation curve to the right, increased erythropoiesis, and an increase in the efficiency of tissue oxygen utilization. The article also studies the differences in compensatory mechanisms in the types of hemolytic anemia, the pathophysiological basis of compensation, and the limits of compensatory capacity in various hemolytic anemias (e.g., hereditary spherocytosis, OAVK deficiency, paroxysmal nocturnal hemoglobinuria, etc.). The body's ability to compensate determines the severity of hemolytic anemia and often causes a relatively mild manifestation of clinical signs of anemia. However, compensatory mechanisms are limited, and after a certain point, a state of decompensation may develop. This article also highlights the clinical importance of taking into account compensatory mechanisms in the treatment of patients with hemolytic anemia.
Keywords
Hemolytic anemia, compensation mechanisms, erythropoiesis
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Copyright (c) 2025 Azimova Sevara Bakhodirovna, Tajibayeva Rana Bakhodirovna, Yakubjonov Kudratilla Khojiakbar oglu
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