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DOI: Autoimmune Thyroiditis And Characteristics Of Disorders Of Reproductive Function In Women Of Fertile Age
Ismailov Said , Doctor Of Medical Sciences, Professor, Head Of The Department Of Endocrinology With Pediatric Endocrinology, Tashkent Pediatric Medical Institute, Uzbekistan Abduraxmanova Ruxsora , Master Student, Department Of Endocrinology With Pediatric Endocrinology, Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan Urmanova Yulduz , Dr. Med. Sci., Associate Professor, Leading Researcher Of The Department Of Neuroendocrinology Of The Republican Specialized Scientific And Practical Medical Center Of Endocrinology, Tashkent, Republic Of UzbekistanAbstract
The aim is to study the review of the literature review on autoimmune thyroiditis and violations of the reproductive function in women of fertile age
Methods. In total, 100 cases of Ait in women of fertile age with various disorders of the menstrual function (MF) and the reproductive system (PC) were studied. The average age of women was ranging from 18 to 45 years (31.5 ± 0.4).
All 100 patients were performed by a study spectrum, including the study of endocrine status (anthropometric - height, weight, waist volume, thighs, body weight index), general crystal, biochemical, hormonal (TSH, LG, FSH, prolactin, estradiol, progesterone, free thyroxine, antibodies to TPO and other - in the laboratory of radioimmune hormonal studies of the RSNPMC Endocrinology of the Ministry of Health of Ruz. In addition, they performed an ultrasound study of the brief and genital organs, an ECG, as well as a study of the quality of life on the questionnaire of The World Health Organization Quality Of Life (WHOQOL -Qol).
Research results. Depending on the body mass index (BMI), the patients were distributed into 2 groups: 1 group - patients with ait with soblinic hypothyroidism -48 (48.0%) patients, 2 groups - patients with AIT with manifestic hypothyroidism - 52 (52.0%) patients.
In the structure of violations of MC in women, the 1st groups were allowed -24.6%, secondary amenorrhea -12.5%. These patients had a history of miscarriage (12.5%), stillbirth (14.6%). Violations of reproductive function were not observed.
In the structure of violations of the MC in women, 2 groups were an olnognosorya -59.6%, the metrrahny frequency is 21.2%, secondary amenorrhea -19.2%. For this category of patients, a high frequency of violations of the reproductive system (53.9%) is characterized, of which: primary infertility was observed in 40.4% of cases, secondary infertility - 13.5% of cases. These patients had a history of miscarriage (32.8%), stillbirth (39.8%), butorous prevention of the fetus (22.7%).
Conclusions. 1) The first stage in the treatment of menstrual disorders and infertility in women with ait should be the correction of excess body weight. 2) Most often, the violation of the MC and the reproductive function was observed in patients with ait and 1 degree of obesity than with ait and normal body weight.
Keywords
Autoimmune thyroiditis, women, disorders of reproductive function
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