Agriculture and Biomedical
| Open Access |
DOI: Hypotensive Effect Of The Plant Alkaloid Digitaalisen On The Functional Activity Of Mmc Aortic Chrysallida Of Dihydroemetine On The Functional Activity Of Smc In The Aorta Of The Rat
Muazzam Bakiyeva , Namangan state university, Uzbekistan Shokhista Rustamova , Namangan state university, Uzbekistan Yodgormirza Nurmatov , Namangan state university, UzbekistanAbstract
Effect of dihydroatizin (5–250 μmol / L) on the contractile activity of rat smooth aorta muscle cells (SMC). Isometric tensile forces were recorded. Using a force transducer FT - 03 (Grass Instrument Co., USA). In it was found by experiments that the vasodilating effect of dihydroatizin mainly associated with the blockade of the Ca2 + L-channel.
Methods-Preparation of the aortic vessel muscle preparation, and recording the force of contraction.
Results- KCI-induced contraction of the aortic MMC is associated with the activation of potential–dependent Ca2+L channels of the plasma membranes of the MMC
Conclusions- The data obtained as a result of studying the mechanisms of action of the alkaloid dihydroathysine are of great practical importance and can be recommended for optimizing the process of purposeful creation of a new generation of vasorelaxant drugs.
Keywords
SERCA – SR Ca2 –Atphase, NCX – Na /Ca2 –exchanger, eNOS – endothelial NO–synthase
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