Effect of A Modified Ketogenic Diet on Carbohydrate and Lipid Metabolism in Experimental Metabolic Syndrome

Metabolic syndrome is a complex metabolic condition characterized by insulin resistance, hyperglycemia, and atherogenic dyslipidemia, and modification of dietary composition is considered an important approach to its correction. The aim of the study was to dynamically and comparatively evaluate the effect of a modified ketogenic diet on carbohydrate and lipid metabolism parameters under conditions of experimental metabolic syndrome. During the correction stage, the animals were divided into seven groups: intact control, metabolic syndrome control, MS + traditional ketogenic diet (TKD), MS + modified ketogenic diet (MKD), MS + ezetimibe, MS + metformin, and MS + metformin + ezetimibe (n=8 in each group). The MKD consisted of 60% fat, 30% protein, and 10% carbohydrate. Correction was continued for 30 days, and glucose, insulin, total cholesterol, triglycerides (TG), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) were assessed on days 10, 20, and 30. In the MKD group, glucose decreased from 6.9 mmol/L on day 10 to 4.8 mmol/L on day 30, insulin from 20.6 to 17.7, total cholesterol from 5.8 to 3.3 mmol/L, TG from 1.70 to 1.22 mmol/L, and LDL from 0.93 to 0.59 mmol/L, whereas HDL increased from 0.61 to 0.70 mmol/L. The results demonstrated that MKD was associated with favorable correction of carbohydrate and lipid metabolism disturbances in experimental metabolic syndrome.

Metabolic syndrome, modified ketogenic diet, glucose

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