Toxicity and Cumulative Effect Study of "Benzpaya - S" Dental Gel

Studies were conducted to investigate the toxicological effects—specifically the safety and cumulative action—of a new combined dosage form in the gel format based on benzketozone and papaya extract. Experiments were performed on oral mucosal wounds and cutaneous wounds in a rat model. A comparative analysis of the wound-healing activity of the new gel composition "Benzpaya" was carried out against the reference drugs Asepta gel and Solcoseryl gel, demonstrating the clear advantage of the former. The developed gel has the potential to become an alternative agent for the treatment and prevention of dental diseases with a minimal risk of side effects. The new composition of "Benzpaya" gel at a dose of 150 mg/kg possesses wound-healing activity, reducing wound cleansing and healing time by 4–8 days. A comparative analysis with the reference drugs Asepta gel and Solcoseryl revealed the superiority of the evaluated formulation.

Results of the acute toxicity study of the new composition "Benzpaya-S" gel demonstrated that it belongs to Class VI of relatively harmless substances. The LD50 in mice upon oral administration was greater than or equal to 5000 mg/kg (≥ 5000 mg/kg). Furthermore, an absence of both cumulative action and habituation (tolerance) was noted.

Dental diseases, nonsteroidal anti-inflammatory drugs, phenylglyoxylic acid

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