Medical Science
| Open Access |
DOI: Pharmaceutical and Biopharmaceutical Characteristics of Montelukast Preparations Used in The Treatment of Bronchial Asthma
Axmadjonov Axmadjon , Kokand University Andijan Branch, Babur street, 170100, Uzbekistan Matazimov Muhammadjon , Nuraliyeva Madina , Andijan State Medical Institute, Andijan city, Republic of UzbekistanAbstract
Bronchial asthma is considered one of the most widespread chronic inflammatory diseases globally, and leukotriene receptor antagonists occupy an important place in its pharmacotherapy. Montelukast sodium is one of the highly effective antileukotriene drugs widely used in the treatment of bronchial asthma and allergic rhinitis, and it is manufactured in generic forms by various pharmaceutical companies. Variations in excipient composition, manufacturing technology, stability indicators, and biopharmaceutical properties of preparations containing the identical active substance can significantly influence their therapeutic efficacy and overall quality. In this article, the pharmaceutical and biopharmaceutical characteristics of domestic and foreign montelukast-based tablet preparations were analyzed based on modern scientific literature. The literature review elucidates the chemical composition of the preparations, the role of excipients, dissolution profiles, bioequivalence, stability, and quality control methods, including HPLC and UV-spectrophotometric analytical methods. Furthermore, the key factors influencing the quality parameters of generic preparations were scientifically evaluated. The obtained data indicate that an in-depth study of the pharmaceutical equivalence of montelukast preparations and the optimization of their quality control are of profound importance.
Keywords
Bronchial asthma, montelukast sodium, generic preparations
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Copyright (c) 2026 Axmadjonov Axmadjon, Matazimov Muhammadjon, Nuraliyeva Madina
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