Medical Science
| Open Access |
DOI: The Role of Connective Tissue Dysplasia in Post-Treatment Recurrences of Funnel Chest in Children
Ruzikulov U.Sh , Tashkent State Medical University, UzbekistanAbstract
The article highlights the importance of biochemical investigations in children with thoracic cage whirl-like dysplastic deformities. Quantitative analyses of proline, hydroxyproline and glucosaminoglycans were carried out. The study was based on the examination results of 64 young children. The patients' medical history revealed that a whirlpool deformity was noted from an early age in 30 (58%) children, while in 12 (23%) patients, the disease manifested in the first year of life, In 10 (19%) children, the deformity appeared by the age of 3.
The patients were divided into groups according to age for analysis. It was found that, depending on the degree of connective tissue dysplasia observed in the patients, the biochemical markers shifted in a positive direction following treatment.
Keywords
Chest wall, funnel-shaped deformity, connective tissue dysplasia
References
Zemtsovsky E.V. General characteristics of hereditary disorders (dysplasias) of connective tissue / E.V. Zemtsovsky, V.N. Gorbunova // Bulletin of the V.A. Almazov Federal Center for Heart, Blood, and Endocrinology. - 2013. - No. 4. - pp. 47-55.
Kadurina T.I. Hereditary and multifactorial connective tissue disorders in children. Diagnostic algorithms. Treatment tactics. //Scientific and practical journal “Medical Bulletin of the North Caucasus.” 2015. Vol. 10, No. 1.5-35 pp.
Khodjanov I.Yu., Ruzikulov U.Sh., Nurmukhamedov Kh.K., Narzikulov U.K. The use of pharmacological therapy to improve the results of surgical treatment of children with funnel chest deformity // Issues of reconstructive and plastic surgery, Russia, Tomsk - 2019. – Volume 22, No. 4(71). – P. 65-73.
Khodjanov I.Yu., Irismetov M.E., Khakimov Sh.K., Ruzikulov U.Sh., Mirzakarimov B.Kh. Analysis of the effectiveness of treatment for funnel chest deformity // Scientific and practical journal “Traumatology, Orthopedics and Rehabilitation.” 2020: No. 2. 55-59.
Lee K., et al. Pediatric Chest Wall Dysplasia: Early Diagnosis and Conservative Therapy. J Pediatr Surg, 2021.
Kim H., et al. Non-surgical Treatment of Pectus Deformities in Children. Clin Orthop Relat Res, 2019.
Zhang Y., et al. Genetic and Biochemical Markers in Pediatric Chest Wall Deformities. Genet Med, 2022.
Johnson P., et al. Surgical Correction of Severe Pectus Deformities in Children. J Pediatr Orthop, 2018.
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