The conducted study provides a comprehensive analysis of implementing vegan formulations in professional eyelash and eyebrow products in light of the updated requirements of the United States Food and Drug Administration (FDA) set forth by the Modernization of Cosmetics Regulation Act (MoCRA). The aim is to evaluate the chemical stability, functional characteristics, and allergy profile of vegan substitutes for traditional ingredients and to determine pathways to align them with tightened safety standards. The methodological approach includes a systematic review of scientific publications, content analysis of FDA regulatory materials and manufacturers’ technical dossiers, as well as synthesis of data from industry reports. The work demonstrates that the shift to vegan formulas in eyelash extension adhesives, eyebrow dyes, and lamination compositions generally preserves key synthetic actives (in particular, cyanoacrylates and p-phenylenediamine derivatives), creating a vegan paradox in which marketing notions of naturalness and safety diverge from the actual chemical nature of the products. It is established that the main vegan alternative to p-phenylenediamine (PPD), toluene-2,5-diamine sulfate (PTDS), is characterized by a high level of cross-reactivity (≈42,9%), which substantially limits its hypoallergenic potential. It is concluded that MoCRA shifts manufacturers from declarative promises to evidence-based safety substantiation, complicating and increasing the cost of bringing vegan products to market. The material is addressed to cosmetic industry chemical technologists, regulatory specialists, dermatologists, and practicing beauty-service professionals.

vegan cosmetics, eyelash extensions, eyebrow dye, Modernization of Cosmetics Regulation Act (MoCRA), FDA 2025, allergic contact dermatitis, p-phenylenediamine (PPD)

Vegan Cosmetics Market Report 2025 [Electronic resource]. - Access mode: https://www.researchandmarkets.com/reports/5766750/vegan-cosmetics-market-report (date accessed: 09/12/2025).

Vegan Cosmetics Market Size, Share & Trends Forecast 2033 [Electronic resource]. - Access mode: https://www.imarcgroup.com/vegan-cosmetics-market (date accessed: 09/14/2025).

Vegan Cosmetics Market Report 2025 - Trends And Forecast 2034 [Electronic resource]. - Access mode: https://www.thebusinessresearchcompany.com/report/vegan-cosmetics-global-market-report (date accessed: 09/14/2025).

7 trends shaping the beauty industry in 2024 | Radial [Electronic resource]. - Access mode: https://www.radial.com/eur/insights/7-trends-shaping-the-beauty-industry-in-2024 (date accessed: 09/15/2025).

Registration & Listing of Cosmetic Product Facilities and Products - FDA [Electronic resource]. - Access mode: https://www.fda.gov/cosmetics/registration-listing-cosmetic-product-facilities-and-products (date accessed: 09/16/2025).

Modernization of Cosmetics Regulation Act of 2022 (MoCRA) - FDA [Electronic resource]. - Access mode: https://www.fda.gov/cosmetics/cosmetics-laws-regulations/modernization-cosmetics-regulation-act-2022-mocra (date accessed: 09/16/2025).

Meet MoCRA: Getting to Know the Modernization of Cosmetics Regulation Act - Food and Drug Law Institute (FDLI) [Electronic resource]. - Access mode: https://www.fdli.org/2023/04/meet-mocra-getting-to-know-the-modernization-of-cosmetics-regulation-act/ (date accessed: 09/16/2025).

MoCRA Increases FDA Oversight of the Cosmetics Industry [Electronic resource]. - Access mode: https://www.loeb.com/en/insights/publications/2023/03/mocra-increases-fda-oversight-of-the-cosmetics-industry (date accessed: 09/16/2025).

Zirwas M. J. Contact dermatitis to cosmetics //Clinical Reviews in Allergy & Immunology. – 2019. – Vol. 56 (1). – pp. 119-128.

Hafner M. F. S., Rodrigues A. C., Lazzarini R. Allergic contact dermatitis to cosmetics: retrospective analysis of a population subjected to patch tests between 2004 and 2017 //Anais brasileiros de dermatología. – 2020. – Vol. 95. – pp. 696-701. https://doi.org/10.1016/j.abd.2020.04.011.

Diepgen T. L., Weisshaar E. Contact dermatitis: epidemiology and frequent sensitizers to cosmetics //Journal of the European Academy of Dermatology and Venereology. – 2007. – Vol. 21. – pp. 9-13. https://doi.org/10.1111/j.1468-3083.2007.02381.x.

Needle C. D. et al. Contact Allergens in “PPD-Free” Hair Dyes //Dermatitis®. – 2025. https://doi.org/10.1089/derm.2024.0542.

Venkatesan G. et al. Development of novel alternative hair dyes to hazardous para-phenylenediamine //Journal of Hazardous Materials. – 2021. – Vol. 402. https://doi.org/10.1016/j.jhazmat.2020.123712

Palaniappan V., Karthikeyan K., Anusuya S. Dermatological adverse effects of hair dye use: A narrative review //Indian Journal of Dermatology, Venereology and Leprology. – 2024. – Vol. 90 (4). – pp. 458-470.

Comby P. O. et al. Endovascular use of cyanoacrylate-lipiodol mixture for peripheral embolization: properties, techniques, pitfalls, and applications //Journal of Clinical Medicine. – 2021. – Vol 10 (19). https://doi.org/10.3390/jcm10194320.

Perinelli D. R. et al. Exploring the Functional Properties of Hydrolyzed Keratin: Filling the Knowledge Gap on Surface Active, Emulsifying, and Thickening Properties //ACS omega. – 2025. – Vol. 10 (12). – pp. 12224-12232.

Pan J. et al. Beyond benchmarks: Dynamic, automatic and systematic red-teaming agents for trustworthy medical language models //arXiv preprint arXiv:2508.00923. – 2025. https://doi.org/10.48550/arXiv.2508.00923.

Guidance for Industry: Registration and Listing of Cosmetic Product Facilities and Products - FDA [Electronic resource]. - Access mode: https://www.fda.gov/media/170732/download (date accessed: 09/20/2025).

FDA Regulation of Cosmetics and Personal Care Products Under the Modernization of Cosmetics Regulation Act of 2022 (MoCRA) [Electronic resource]. - Access mode: https://www.congress.gov/crs-product/R47826 (date accessed: 09/20/2025).

Guidance for Industry: Registration and Listing of Cosmetic Product Facilities and Products [Electronic resource]. - Access mode: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/guidance-industry-registration-and-listing-cosmetic-product-facilities-and-products (date accessed: 09/22/2025).

MATERIAL SAFETY DATA SHEET - Ellisons [Electronic resource]. - Access mode: https://www.ellisons.co.uk/content/ellisons/products/datasheets/TH11102051_TH11102046_TH11102049_TH11102050_TH11102045_TH11102054_TH11102047_TH11102016_TH11102053_TH11102052_Thuya_lashbrow_tint_14ml_Datasheet.pdf (date accessed: 10/10/2025).

Thuya Brow Lamination Kit | Trusted by Professionals Worldwide [Electronic resource]. - Access mode: https://thuyanyc.com/products/thuya-eyebrow-lamination-kit (date accessed: 10/10/2025).

Adhesive finder - LashBox LA Australia [Electronic resource]. - Access mode: https://lashboxla.com.au/pages/adhesive-finder (date accessed: 10/10/2025).

Elleebana Elleeplex Regen 20 ml - Salon First Beauty Supplies [Electronic resource]. - Access mode: https://www.salonfirst.com.au/elleebana-elleeplex-regen (date accessed: 10/12/2025).

RefectoCil No. 3.1 Light Brown - Silverlines AS [Electronic resource]. - Access mode: https://silverlines.no/images_hovedside/2022%20PRODUKTDOKUMENTER/100006177%20PRODUKTBLAD.pdf (date accessed: 10/12/2025).

Refectocil - Lash & Brow Tint - Bella Beauty Professional [Electronic resource]. - Access mode: https://bellabeautyprofessional.com/products/refectocil-lash-brow-tint (date accessed: 10/12/2025).

brow bomber > brow lamination - InLei® [Electronic resource]. - Access mode: https://inlei.com/collections/inlei%C2%AE-brow-bomber (date accessed: 10/12/2025).

Material Safety Data Sheet - NovaLash [Electronic resource]. - Access mode: https://novalash.com/wp-content/uploads/2015/07/MSDS.PlatBond_R08052009.pdf (date accessed: 10/12/2025).

Beauty - McKinsey [Electronic resource]. - Access mode: https://www.mckinsey.com/~/media/mckinsey/industries/consumer%20packaged%20goods/our%20insights/state%20of%20beauty/2025/the-state-of-fashion-beauty-june-2025-f.pdf (date accessed: 10/15/2025).

A close look at the global beauty industry in 2025 - McKinsey [Electronic resource]. - Access mode: https://www.mckinsey.com/industries/consumer-packaged-goods/our-insights/a-close-look-at-the-global-beauty-industry-in-2025 (date accessed: 10/15/2025).

State of Beauty industry trends 2025 | McKinsey [Electronic resource]. - Access mode: https://www.mckinsey.com/industries/consumer-packaged-goods/our-insights/state-of-beauty (date accessed: 10/17/2025).

FDA Authority Over Cosmetics: How Cosmetics Are Not FDA-Approved, but Are FDA-Regulated | FDA [Electronic resource]. - Access mode: https://www.fda.gov/cosmetics/cosmetics-laws-regulations/fda-authority-over-cosmetics-how-cosmetics-are-not-fda-approved-are-fda-regulated (date accessed: 10/17/2025).