Rabies, caused by the neurotropic rabies virus, presents a unique challenge to the immune system, employing sophisticated strategies for evasion and subversion. This paper delves into the intricate mechanisms by which the rabies virus avoids detection and neutralization by the host immune system. From exploiting the blood-brain barrier to manipulating immune response pathways, the virus employs a repertoire of tactics to establish and propagate infection within the central nervous system. Understanding these evasion strategies is crucial for developing effective antiviral interventions. This review synthesizes current knowledge on the immunoevasive tactics of the rabies virus, shedding light on potential targets for therapeutic intervention and advancing our ability to combat this deadly viral infection.

Rabies, Immune evasion, Host subversion

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